Zobrazeno 1 - 5
of 5
pro vyhledávání: '"Alan J. Dipesa"'
Autor:
Michel Gillard, Alan J. Dipesa, Donna M. Wypij, Ralph Scannell, Lyn Libertine, Young Michelle, Timothy A. Lewis, Joseph Eckman, Lynn Bayless
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 15:1083-1085
A series of N-hydroxycarbamates containing a histaminergic H1 receptor antagonist pharmacophore was synthesized. In vitro assays determined the compounds had both histaminergic binding and 5-lipoxygenase inhibiting activities comparable to the corres
Autor:
Alexander Giannaras, Nathalie Van houtvin, Dorin Preda, Dong Zou, Maggi Burton, Frédéric Denonne, Patrick Pasau, Jean-Marie Nicolas, Alan J. Dipesa, Andrew Volosov, Sophie Binet, Philippe Collart, Seema Kumar, Sabine Defays, Maria Eckert, Cecile Pegurier, Beth Levine
Publikováno v:
Bioorganicmedicinal chemistry letters. 17(12)
The synthesis and structure-activity relationships against the C3a receptor of a series of substituted aminopiperidine derivatives are reported. DMPK properties and functional activities of selected compounds are described. The compounds obtained are
Autor:
Alexander Volosov, Tamsin Mansley, Patrick Pasau, Frédéric Denonne, Sophie Binet, Jean-Marie Nicolas, Philippe Collart, Alan J. Dipesa, Seema Kumar, Alexander Giannaras, Maggi Burton, Dong Zou, Dorin Preda, Tanmoy Ganguly, Karin J. Stebbins, Florence Maounis, Timothy A. Lewis
Publikováno v:
Bioorganicmedicinal chemistry letters. 17(12)
The synthesis and in vitro binding of several new arginine-containing C3aR ligands are reported. DMPK properties and functional activities of selected compounds have been evaluated. One compound is shown to be active in an in vivo model of airway inf
Autor:
Thomas J. Carty, Weiling Cai, Nancy C. Elliott, Alan J. Dipesa, Seungil Han, David H. Brown Ripin, Francis J. Sweeney, Eric S. Marr, Ellen R. Laird, Mark A. Dombroski, Douglas H. Tan, Santo R. Cortina, Yong Tao, John T. Barberia, Dennis E. Danley, Jayvardhan Pandit, Thomas R Hynes, Mahmoud N. Mansour, Kim F. McClure, Christopher A. Gabel, Kathleen M. Donahue, Peter K. LeMotte, Yuriy A. Abramov, Michael A. Letavic
Publikováno v:
Journal of medicinal chemistry. 48(18)
Mimics of the benzimidazolone nucleus found in inhibitors of p38 kinase are proposed, and their theoretical potential as bioisosteres is described. A set of calculated descriptors relevant to the anticipated binding interaction for the fragments 1-me
Autor:
Michael A. Letavic, Linne Svensson, Kevin M. Peese, Alan J. Dipesa, Crystal K. Jordan, Santo R. Cortina, Ingrid A. Stock, Kim F. McClure, Nancy C. Elliott, Christopher A. Gabel, Jeff M. Labasi, Chul Yu, William H. Martin, Mark A. Dombroski, John T. Barberia, Thomas J. Carty, Csilla Csiki, Francis J. Sweeney
Publikováno v:
Bioorganicmedicinal chemistry letters. 14(4)
The synthesis and in vitro p38 alpha activity of a novel series of benzimidazolone inhibitors is described. The p38 alpha SAR is consistent with a mode of binding wherein the benzimidazolone carbonyl serves as the H-bond acceptor to Met109 of p38 alp