Zobrazeno 1 - 10
of 194
pro vyhledávání: '"Alan J. Cross"'
Autor:
Emily E. Burke, Joshua G. Chenoweth, Joo Heon Shin, Leonardo Collado-Torres, Suel-Kee Kim, Nicola Micali, Yanhong Wang, Carlo Colantuoni, Richard E. Straub, Daniel J. Hoeppner, Huei-Ying Chen, Alana Sellers, Kamel Shibbani, Gregory R. Hamersky, Marcelo Diaz Bustamante, BaDoi N. Phan, William S. Ulrich, Cristian Valencia, Amritha Jaishankar, Amanda J. Price, Anandita Rajpurohit, Stephen A. Semick, Roland W. Bürli, James C. Barrow, Daniel J. Hiler, Stephanie C. Page, Keri Martinowich, Thomas M. Hyde, Joel E. Kleinman, Karen F. Berman, Jose A. Apud, Alan J. Cross, Nicholas J. Brandon, Daniel R. Weinberger, Brady J. Maher, Ronald D. G. McKay, Andrew E. Jaffe
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-14 (2020)
Here, authors present results of a hiPSC transcriptomics study on corticogenesis from multiple donors across four transitions in differentiation. They present a bulk data deconvolution method and show that co-culturing human NPCs with rodent astrocyt
Externí odkaz:
https://doaj.org/article/a91415f76f3b4ff6b00a1fb9ef500aaf
Autor:
Carrie Wright, Anandita Rajpurohit, Emily E. Burke, Courtney Williams, Leonardo Collado-Torres, Martha Kimos, Nicholas J. Brandon, Alan J. Cross, Andrew E. Jaffe, Daniel R. Weinberger, Joo Heon Shin
Publikováno v:
BMC Genomics, Vol 20, Iss 1, Pp 1-21 (2019)
Abstract Background RNA sequencing offers advantages over other quantification methods for microRNA (miRNA), yet numerous biases make reliable quantification challenging. Previous evaluations of these biases have focused on adapter ligation bias with
Externí odkaz:
https://doaj.org/article/27901c70dc3342d4822f75b17d50b28f
Autor:
Nicola Micali, Suel-Kee Kim, Marcelo Diaz-Bustamante, Genevieve Stein-O’Brien, Seungmae Seo, Joo-Heon Shin, Brian G. Rash, Shaojie Ma, Yanhong Wang, Nicolas A. Olivares, Jon I. Arellano, Kristen R. Maynard, Elana J. Fertig, Alan J. Cross, Roland W. Bürli, Nicholas J. Brandon, Daniel R. Weinberger, Joshua G. Chenoweth, Daniel J. Hoeppner, Nenad Sestan, Pasko Rakic, Carlo Colantuoni, Ronald D. McKay
Publikováno v:
Cell Reports, Vol 31, Iss 5, Pp - (2020)
Summary: Better understanding of the progression of neural stem cells (NSCs) in the developing cerebral cortex is important for modeling neurogenesis and defining the pathogenesis of neuropsychiatric disorders. Here, we use RNA sequencing, cell imagi
Externí odkaz:
https://doaj.org/article/09028c601a8b4575b9d6ec90dadc6fb0
Autor:
Mark A. Smith, Kosha Ruparel, Theodore D. Satterthwaite, Mary E. March, Bruce I. Turetsky, Christian G. Kohler, Daniel H. Wolf, Mark A. Elliott, Raquel E. Gur, Stephen R. Zukin, Ruben C. Gur, David Zheng, Alan J. Cross
Publikováno v:
Molecular Psychiatry. 27:1226-1232
Negative symptoms and cognitive deficits contribute strongly to disability in schizophrenia, and are resistant to existing medications. Recent drug development has targeted enhanced NMDA function by increasing mGluR2/3 signaling. However, the clinica
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f53b268ab69c0a862f7b4e82e3186897
https://doi.org/10.1038/s41380-021-01320-w
https://doi.org/10.1038/s41380-021-01320-w
Autor:
Alan J. Cross, Stephen A. Semick, Andrew E. Jaffe, Daniel R. Weinberger, Thomas M. Hyde, Ran Tao, Liang Ma, Joel E. Kleinman, Qiang Chen, Richard E. Straub, Amanda J. Price, Nicholas J. Brandon, Yankai Jia, Chao Li, Joo Heon Shin
Publikováno v:
Molecular Psychiatry. 25:831-843
Genome-wide association studies (GWAS) have identified many genomic loci associated with risk for schizophrenia, but unambiguous identification of the relationship between disease-associated variants and specific genes, and in particular their effect
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a0e6edb3800e002773db85ce1638c10c
https://doi.org/10.1038/s41380-018-0293-0
https://doi.org/10.1038/s41380-018-0293-0
Publikováno v:
Addict Biol
Fyn is a member of the Src family of protein tyrosine kinases (PTKs) that plays an important role not only in normal synaptic functions but also in brain pathologies including alcohol use disorder. We previously reported that repeated cycles of binge
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f9d9dcc8e172a4930253359d91a7f2fb
https://doi.org/10.1111/adb.12699
https://doi.org/10.1111/adb.12699
Autor:
Suel-Kee Kim, Seungmae Seo, Genevieve Stein-O’Brien, Amritha Jaishankar, Kazuya Ogawa, Nicola Micali, Victor Luria, Amir Karger, Yanhong Wang, Thomas M. Hyde, Joel E. Kleinman, Ty Voss, Elana J. Fertig, Joo-Heon Shin, Roland Bürli, Alan J. Cross, Nicholas J. Brandon, Daniel R. Weinberger, Joshua G. Chenoweth, Daniel J. Hoeppner, Nenad Sestan, Carlo Colantuoni, Ronald D. McKay
Variability between human pluripotent stem cell (hPSC) lines remains a challenge and opportunity in biomedicine. We identify differences in the spontaneous self-organization of individual hPSC lines during self-renewal that lie along a fundamental ax
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f80b972799b50976aa623fec2ea0bdbd
https://doi.org/10.1101/2021.03.17.435870
https://doi.org/10.1101/2021.03.17.435870
Autor:
Daniel H, Wolf, David, Zheng, Christian, Kohler, Bruce I, Turetsky, Kosha, Ruparel, Theodore D, Satterthwaite, Mark A, Elliott, Mary E, March, Alan J, Cross, Mark A, Smith, Stephen R, Zukin, Ruben C, Gur, Raquel E, Gur
Publikováno v:
Molecular psychiatry. 27(2)
Negative symptoms and cognitive deficits contribute strongly to disability in schizophrenia, and are resistant to existing medications. Recent drug development has targeted enhanced NMDA function by increasing mGluR2/3 signaling. However, the clinica
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::d796d1eb8541d2f1db74b314c04c96df
https://pubmed.ncbi.nlm.nih.gov/34667261
https://pubmed.ncbi.nlm.nih.gov/34667261
Autor:
Abigail Mariga, Ian M. Hardern, Huijun Wei, Roland Bürli, Daniel R. Weinberger, Steven Wesolowski, Ronald D.G. McKay, Alan J. Cross, Hongming Chen, Kara Herlihy, Glen Ernst, James C. Barrow, Nicholas J. Brandon
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 28:3231-3235
Due to increased interest in As(III) S-adenosylmethionine methyltransferase (AS3MT), a search for chemical probes that can help elucidate function was initiated. A homology model was built based on related enzymes, and virtual screening produced 426
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::df456334df7ee822874b062b9778e38c
https://doi.org/10.1016/j.bmcl.2018.08.012
https://doi.org/10.1016/j.bmcl.2018.08.012
Autor:
Colleen M. Niswender, Douglas Shaw, Jonas Bergare, Alan J. Cross, Daniel E. O’Brien, Andrew S. Felts, P. Jeffrey Conn, Steven Wesolowski, Charles S. Elmore, Craig W. Lindsley, Hyekyung P. Cho
Publikováno v:
Molecular Pharmacology. 93:526-540
Allosteric modulation of metabotropic glutamate receptor 2 (mGlu2) has demonstrated efficacy in preclinical rodent models of several brain disorders, leading to industry and academic drug discovery efforts. Although the pharmacology and binding sites
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::64ce8088e13d86301745995d6a424d9c
https://doi.org/10.1124/mol.117.110114
https://doi.org/10.1124/mol.117.110114