Zobrazeno 1 - 10
of 77
pro vyhledávání: '"Alan J. Bitonti"'
Autor:
Garabet G Toby, Tongyao Liu, Yang Buyue, Xin Zhang, Alan J Bitonti, Glenn F Pierce, Jurg M Sommer, Haiyan Jiang, Robert T Peters
Publikováno v:
PLoS ONE, Vol 11, Iss 2, p e0148255 (2016)
INTRODUCTION:Hemophilia B is an inherited X chromosome-linked disorder characterized by impaired blood clotting owing to the absence of functional coagulation factor IX. Due to the relatively short half-life of factor IX, patients with hemophilia B r
Externí odkaz:
https://doaj.org/article/58c4ecd32473436ca225422f97a166da
Autor:
Andrew E Nixon, Jie eChen, Daniel J Sexton, Arumugam eMuruganandam, Alan J Bitonti, Jennifer eDumont, Malini eViswanathan, Diana eMartik, Dina eWassaf, Adam eMezo, Clive R Wood, Joseph C Biedenkapp, Christopher eTenHoor
Publikováno v:
Frontiers in Immunology, Vol 6 (2015)
The therapeutic management of antibody mediated autoimmune disease typically involves immunosuppressant and immunomodulatory strategies. However, perturbing the fundamental role of the neonatal Fc receptor (FcRn) in salvaging IgG from lysosomal degra
Externí odkaz:
https://doaj.org/article/93695677b70b4ff8a92947f67b2596cb
Autor:
S Purohit, K Lasseter, Amit Gandhi, Derry C. Roopenian, Robert George Edward Holgate, Jonathan J. Hubbard, J E Humphries, L E Stolz, Jan Terje Andersen, Michal Pyzik, Atiya Mahmood, D de Graaf, Susan D. Jones, Arron Hearn, Alan J. Bitonti, J S Graydon, Richard S. Blumberg, K Kacena, Laurence J. Blumberg, Gregory J. Christianson, B Del Tito, L B Pearce, J. Cheung
Publikováno v:
Science Advances
Therapeutic blockade of FcRn in humans decreases IgG and IgG immune complex levels with the attendant immunologic implications.
The neonatal crystallizable fragment receptor (FcRn) functions as an intracellular protection receptor for immunoglob
The neonatal crystallizable fragment receptor (FcRn) functions as an intracellular protection receptor for immunoglob
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7956be3e71940724cce8ce3634ea7a40
http://hdl.handle.net/10852/76135
http://hdl.handle.net/10852/76135
Biochemical and functional characterization of a recombinant monomeric factor VIII–Fc fusion protein
Autor:
Qi Lu, John Kulman, Glenn F. Pierce, Robert T. Peters, Low Susan, Alan J. Bitonti, Garabet G. Toby, Tongyao Liu
Publikováno v:
Journal of Thrombosis and Haemostasis
Background: Hemophilia A results from a deficiency in factor VIII activity. Current treatment regimens require frequent dosing, owing to the short half-life of FVIII. A recombinant FVIII–Fc fusion protein (rFVIIIFc) was molecularly engineered to in
Autor:
Paul Sakorafas, Low Susan, Qi Lu, Sebastien Vallee, Swapnil Rakhe, Sandra Walker, Alan J. Bitonti, Thomas Reidy
Publikováno v:
Journal of Interferon & Cytokine Research. 32:178-184
Currently, products containing interferon beta (IFNβ) are injected either intramuscularly or subcutaneously. To avoid the necessity of injection, we developed a novel monomeric Fc fusion protein of IFNβ (IFNβFc) that is absorbed via an immunoglobu
Autor:
John V. Amari, Robert T. Peters, Kevin Mcdonnell, Qi Lu, Alan J. Bitonti, Todd Hoehn, Adam R. Mezo, Thomas Reidy, Jennifer A. Dumont, Jeff Song, Susan C. Low
Publikováno v:
Bioconjugate Chemistry. 23:518-526
Atrial natriuretic peptide (ANP) may be a useful molecule for the treatment of cardiovascular diseases due to its potent natriuretic effects. In an effort to prolong the short in vivo half-life of ANP, fusions of the peptide to the Fc domain of IgG w
Autor:
Xiaomei Jin, Glenn F. Pierce, Jennifer A. Dumont, Robert T. Peters, Alan J. Bitonti, Alvin Luk
Publikováno v:
Therapeutic Proteins
Autor:
Jie Chen, Dina Wassaf, Malini Viswanathan, Diana Martik, Clive R. Wood, Chris TenHoor, Andrew E. Nixon, Joseph C. Biedenkapp, Daniel J. Sexton, Jennifer A. Dumont, Adam R. Mezo, Arumugam Muruganandam, Alan J. Bitonti
Publikováno v:
Frontiers in Immunology
Frontiers in Immunology, Vol 6 (2015)
Frontiers in Immunology, Vol 6 (2015)
The therapeutic management of antibody mediated autoimmune disease typically involves immunosuppressant and immunomodulatory strategies. However, perturbing the fundamental role of the neonatal Fc receptor (FcRn) in salvaging IgG from lysosomal degra
Autor:
Alan J. Bitonti, Jennifer A. Dumont
Publikováno v:
Advanced Drug Delivery Reviews. 58:1106-1118
We have applied a "physiologic" approach to the pulmonary delivery of therapeutic proteins, utilizing an immunoglobulin (antibody) transport pathway recently shown to be present predominantly in the conducting airways of the human respiratory tract.
Autor:
T B Le, J.T. Tsay, B Cashman, Z Zhao, E A Powers, Paul S. Wright, P C Loos, D.R. Borcherding, Alan J. Bitonti, K Kropp, Jennifer A. Dumont, Norton P. Peet, F Barbone, Philip M. Weintraub, Patrick Wai-Kwok Shum, S Dwyer
Publikováno v:
Nucleosides, Nucleotides and Nucleic Acids. 20:1067-1078
Cyclin-dependent kinases (CDKs) belong to a class of enzymes that control the ability of a cell to enter into and proceed through the cell division cycle. Using purine as a scaffold, we have synthesized a number of nanomolar inhibitors of CDK-2/cycli