A new role for an old enemy

Autor: Richard M Monaghan, Alan J Whitmarsh

Publikováno v: eLife, Vol 4 (2015)

Drugs that change the shape of AKT, a protein kinase that promotes tumor growth, may be more effective than drugs that only target its enzymatic activity.

Externí odkaz: https://doaj.org/article/8cd68bde0ac346b4aef6cea6e17b261f

A new regulator of caveolae signalling

Autor: Alan J Whitmarsh

Publikováno v: eLife, Vol 2 (2013)

Cavin-3 regulates metabolism and cell proliferation by coordinating the activities of growth factor signalling cascades.

Externí odkaz: https://doaj.org/article/f4922878bd6e46f2854665f57235f7e1

Data from Inhibiting ERK5 Overcomes Breast Cancer Resistance to Anti-HER2 Therapy By Targeting the G1–S Cell-Cycle Transition

Autor: Cathy Tournier, Alan J. Whitmarsh, Emanuele Giurisato, Michael J. Cross, Katherine G. Finegan, Blanca Risa-Ebrí, Nathanael S. Gray, Jinhua Wang, Shiyang Li, Fuhui Chen, Wei Zhang, Qiuping Xu, Karmern Kan, Nisha Ali, Brian A. Telfer, Nitin Sabherwal, Adam J. Pearson, Jingwei Zhang

Targeting HER2 has become a landmark in the treatment of HER2-driven breast cancer. Nonetheless, the clinical efficacy of anti-HER2 therapies can be short-lived and a significant proportion of patients ultimately develop metastatic disease and die. O

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::63f4ef5321e6a190602a2d6eeb8a058f
https://doi.org/10.1158/2767-9764.c.6550601.v1

Discovery of a gatekeeper residue in the C-terminal tail of the extracellular signal-regulated protein kinase 5 (ERK5)

Autor: Alan J. Whitmarsh, Gabriela Toro Tapia, Adam J. Pearson, Cathy Tournier, Ian Prise, Allan M. Jordan, Chiara Francavilla, Paul Fullwood, Emanuele Giurisato, Qiuping Xu, Michael P. Smith

Publikováno v: Pearson, A J, Fullwood, P, Tapia, G T, Prise, I, Smith, M P, Xu, Q, Jordan, A, Giurisato, E, Whitmarsh, A J, Francavilla, C & Tournier, C 2020, ' Discovery of a gatekeeper residue in the C-terminal tail of the extracellular signal-regulated protein kinase 5 (ERK5) ', International Journal of Molecular Sciences, vol. 21, no. 3, 929 . https://doi.org/10.3390/ijms21030929
International Journal of Molecular Sciences
Volume 21
Issue 3
International Journal of Molecular Sciences, Vol 21, Iss 3, p 929 (2020)

The extracellular signal-regulated protein kinase 5 (ERK5) is a non-redundant mitogen-activated protein kinase (MAPK) that exhibits a unique C-terminal extension which comprises distinct structural and functional properties. Here, we sought to elucid

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4fd96057873abf3d15188cd22f1efa45
https://doi.org/10.3390/ijms21030929

Mitochondrial Proteins Moonlighting in the Nucleus

Autor: Richard M. Monaghan, Alan J. Whitmarsh

Publikováno v: Trends in Biochemical Sciences. 40:728-735

Mitochondria function as cellular energy generators, producing the fuel required to drive biological processes. The response of cells to mitochondrial activity or dysfunction regulates their survival, growth, proliferation, and differentiation. Sever

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1a6d68cf4deae61384d224d50d18cc4a
https://doi.org/10.1016/j.tibs.2015.10.003