Zobrazeno 1 - 10
of 43
pro vyhledávání: '"Alan J Herr"'
Publikováno v:
eLife, Vol 10 (2021)
Although studies of Saccharomyces cerevisiae have provided many insights into mutagenesis and DNA repair, most of this work has focused on a few laboratory strains. Much less is known about the phenotypic effects of natural variation within S. cerevi
Externí odkaz:
https://doaj.org/article/c7105fd1b6ec43f595ed2466e85f39a3
Autor:
Scott R Kennedy, Eric M Schultz, Thomas M Chappell, Brendan Kohrn, Gary M Knowels, Alan J Herr
Publikováno v:
PLoS Genetics, Vol 11, Iss 4, p e1005151 (2015)
Mutator phenotypes accelerate the evolutionary process of neoplastic transformation. Historically, the measurement of mutation rates has relied on scoring the occurrence of rare mutations in target genes in large populations of cells. Averaging mutat
Externí odkaz:
https://doaj.org/article/33c7657dbb654d398dffdedbb88c520d
Autor:
Alan J Herr, Masanori Ogawa, Nicole A Lawrence, Lindsey N Williams, Julie M Eggington, Mallika Singh, Robert A Smith, Bradley D Preston
Publikováno v:
PLoS Genetics, Vol 7, Iss 10, p e1002282 (2011)
Cells rely on a network of conserved pathways to govern DNA replication fidelity. Loss of polymerase proofreading or mismatch repair elevates spontaneous mutation and facilitates cellular adaptation. However, double mutants are inviable, suggesting t
Externí odkaz:
https://doaj.org/article/33b4d1c1cd8d46d9a63586e035aa683b
Autor:
Ian T. Dowsett, Jessica L. Sneeden, Branden J. Olson, Jill McKay-Fleisch, Emma McAuley, Scott R. Kennedy, Alan J. Herr
Publikováno v:
Communications Biology, Vol 4, Iss 1, Pp 1-11 (2021)
Dowsett et al use a single-cell resolution approach to analyse the distribution of mutations across several divisions in yeast diploid strains mutated in mismatch repair and polymerase delta proofreading. They find that the underlying mutation rate v
Externí odkaz:
https://doaj.org/article/cdf0b96bd3134cc3a6076bda3f0f7872
Autor:
James Annis, Eishi Takahashi, Julia Appelbaum, Jiaming Zhang, Junko Oshima, Deyin Hou, Alan J. Herr, George M. Martin, Forough Sargolzaeiaval
Publikováno v:
DNA Cell Biol
POLD1 encodes the catalytic subunit of DNA polymerase delta (Polδ), the major lagging strand polymerase, which also participates in DNA repair. Mutations affecting the exonuclease domain increase the risk of various cancers, while mutations that cha
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::376dc178a867d22cfb719aac57815033
https://doi.org/10.1089/dna.2019.5125
https://doi.org/10.1089/dna.2019.5125
Autor:
Joseph M Dahl, Natalie Thomas, Maxwell A Tracy, Brady L Hearn, Lalith Perera, Scott R Kennedy, Alan J Herr, Thomas A Kunkel
Publikováno v:
Nucleic Acids Res
We report the properties of two mutations in the exonuclease domain of the Saccharomyces cerevisiae DNA polymerase ϵ. One, pol2-Y473F, increases the mutation rate by about 20-fold, similar to the catalytically dead pol2-D290A/E290A mutant. The other
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f5a7261296f017ce4acb45411acbe7b0
https://pubmed.ncbi.nlm.nih.gov/35037018
https://pubmed.ncbi.nlm.nih.gov/35037018
Autor:
Scott R. Kennedy, Alan J. Herr, Thu H. B. Tran, Ian T. Dowsett, Mitchell B. Lee, Niloufar Ghodsian, Anh B. Diep, Michael G. Kiflezghi, Michael S. Chung, Daniel T. Carr, Katherine A. Grayden, Anna Bode, Thao T Tang, Priya A. Uppal, Daniel E. L. Promislow, Ngoc Han Tran, Brian M. Wasko, Sarah G. Stanton, Yordanos C. Elala, Michael Hope, Matt Kaeberlein
Publikováno v:
Proceedings of the National Academy of Sciences. 116:3062-3071
Mutations accumulate within somatic cells and have been proposed to contribute to aging. It is unclear what level of mutation burden may be required to consistently reduce cellular lifespan. Human cancers driven by a mutator phenotype represent an in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0a67dbe15949814a4c0c083d887da464
https://doi.org/10.1073/pnas.1815966116
https://doi.org/10.1073/pnas.1815966116
Autor:
Scott R. Kennedy, Alan J. Herr, Jill McKay-Fleisch, Ian T. Dowsett, Jessica L. Sneeden, Branden J. Olson, Emma McAuley
Mutations that compromise mismatch repair (MMR) or DNA polymerase exonuclease domains produce mutator phenotypes capable of fueling cancer evolution. Tandem defects in these pathways dramatically increase mutation rate. Here, we model how mutator phe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6bf3fd7a1c148b4b62ade3a820b9ec49
https://doi.org/10.1101/2020.06.21.163451
https://doi.org/10.1101/2020.06.21.163451
Autor:
Ha Doan, Matthew L.C. Brunner, Roy A. Hsu, Michael Muir, Jessie Levin, Ellen Huynh, Zili Yan, Dexter E. Chen, Kathleen L. Helget, Esin Tunali, Luz Valdez, Yen-Chi Feng, Corey Screws, Ken Chen, Rachael K. Tran, Vesal Mobasher, Matt Kaeberlein, Adrian K. Pun, Edward Yang, Justin D. Dillard-Telm, Victor Omokehinde, Toby N. Ven, Scott R. Kennedy, Alan J. Herr, Raheem Knight, Brian M. Wasko, Katherine Brower, Matthew M. Crane, Alexandra Golubeva
The loss of vacuolar/lysosomal acidity is an early event during aging that has been linked to mitochondrial dysfunction. However, it is unclear how loss of vacuolar acidity results in age-related dysfunction. Through unbiased genetic screens, we dete
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9bf00163785b899b759edeef402b942d