Zobrazeno 1 - 10
of 152
pro vyhledávání: '"Alan J Davidson"'
Publikováno v:
eLife, Vol 7 (2018)
Transdifferentiation is the poorly understood phenomenon whereby a terminally differentiated cell acquires a completely new identity. Here, we describe a rare example of a naturally occurring transdifferentiation event in zebrafish in which kidney di
Externí odkaz:
https://doaj.org/article/65cd9f5935134c4dbfe22950007a3c78
Autor:
Richard W Naylor, Charles N J McGhee, Chad A Cowan, Alan J Davidson, Teresa M Holm, Trevor Sherwin
Publikováno v:
PLoS ONE, Vol 11, Iss 10, p e0165464 (2016)
Corneal diseases such as keratoconus represent a relatively common disorder in the human population. However, treatment is restricted to corneal transplantation, which only occurs in the most advanced cases. Cell based therapies may offer an alternat
Externí odkaz:
https://doaj.org/article/70979c0d66714540a41233eeb30982c9
Autor:
Rebecca A Wingert, Rori Selleck, Jing Yu, Huai-Dong Song, Zhu Chen, Anhua Song, Yi Zhou, Bernard Thisse, Christine Thisse, Andrew P McMahon, Alan J Davidson
Publikováno v:
PLoS Genetics, Vol 3, Iss 10, Pp 1922-1938 (2007)
Kidney function depends on the nephron, which comprises a blood filter, a tubule that is subdivided into functionally distinct segments, and a collecting duct. How these regions arise during development is poorly understood. The zebrafish pronephros
Externí odkaz:
https://doaj.org/article/a4577e417e384c8abaf73a46b0d72ea6
Autor:
Min Yang, Lauren N. Lopez, Maya Brewer, Rachel Delgado, Anna Menshikh, Kelly Clouthier, Yuantee Zhu, Thitinee Vanichapol, Haichun Yang, Raymond C. Harris, Leslie Gewin, Craig R. Brooks, Alan J. Davidson, Mark de Caestecker
Publikováno v:
JCI Insight, Vol 8, Iss 20 (2023)
Retinoic acid receptor (RAR) signaling is essential for mammalian kidney development but, in the adult kidney, is restricted to occasional collecting duct epithelial cells. We now show that there is widespread reactivation of RAR signaling in proxima
Externí odkaz:
https://doaj.org/article/1352fa0980e64b42b36f87f9d4c8e2ab
Autor:
Aneta Przepiorski, Thitinee Vanichapol, Eugenel B. Espiritu, Amanda E. Crunk, Emily Parasky, Michael D. McDaniels, Dave R. Emlet, Ryan Salisbury, Cassandra L. Happ, Lawrence A. Vernetti, Matthew L. MacDonald, John A. Kellum, Thomas R. Kleyman, Catherine J. Baty, Alan J. Davidson, Neil A. Hukriede
Publikováno v:
Stem Cell Research & Therapy, Vol 13, Iss 1, Pp 1-16 (2022)
Abstract Background Hemolysis occurs in many injury settings and can trigger disease processes. In the kidney, extracellular hemoglobin can induce damage via several mechanisms. These include oxidative stress, mitochondrial dysfunction, and inflammat
Externí odkaz:
https://doaj.org/article/ed6e39b445874502af0c45f7b56b6278
Autor:
Ji Young Kim, Josie A. Silvaroli, Gabriela Vasquez Martinez, Bijay Bisunke, Alanys V. Luna Ramirez, Laura A. Jayne, Mei Ji He Ho Feng, Bhavya Girotra, Shirely M. Acosta Martinez, Corynne R. Vermillion, Isaac Z. Karel, Nicholas Ferrell, Noah Weisleder, Sangwoon Chung, John W. Christman, Craig R. Brooks, Sethu M. Madhavan, Kari R. Hoyt, Rachel E. Cianciolo, Anjali A. Satoskar, Diana Zepeda-Orozco, Jennifer C. Sullivan, Alan J. Davidson, Amandeep Bajwa, Navjot Singh Pabla
Publikováno v:
Kidney International. 103:1093-1104
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::851b49e05b80446ba666d41a386c83bc
https://doi.org/10.1016/j.kint.2023.02.026
https://doi.org/10.1016/j.kint.2023.02.026
Autor:
Qizheng Wang, Yucui Xiong, Sheng Zhang, Yufei Sui, Cunlai Yu, Peng Liu, Heying Li, Wenjing Guo, Yubo Gao, Aneta Przepiorski, Alan J. Davidson, Meijin Guo, Xiao Zhang
Publikováno v:
Frontiers in Genetics, Vol 12 (2021)
The use of differentiating human induced pluripotent stem cells (hiPSCs) in mini-tissue organoids provides an invaluable resource for regenerative medicine applications, particularly in the field of disease modeling. However, most studies using a kid
Externí odkaz:
https://doaj.org/article/7d999229f8f04e8490a9eaa2490df0a9
Autor:
Veronika Sander, Aneta Przepiorski, Amanda E. Crunk, Neil A. Hukriede, Teresa M. Holm, Alan J. Davidson
Publikováno v:
STAR Protocols, Vol 1, Iss 3, Pp 100150- (2020)
Summary: Kidney organoids represent a physiologically advanced model for studying the mechanisms of kidney development and disease. Here, we describe a simple two-step protocol for the differentiation of human pluripotent stem cells into kidney organ
Externí odkaz:
https://doaj.org/article/2781ad0fc39e463ebce730d990f53b97
Publikováno v:
Cells, Vol 11, Iss 1, p 6 (2021)
The development over the past 50 years of a variety of cell lines and animal models has provided valuable tools to understand the pathophysiology of nephropathic cystinosis. Primary cultures from patient biopsies have been instrumental in determining
Externí odkaz:
https://doaj.org/article/eb8edd33e5e940d58fa9a0acf5d8098a
Autor:
Nicolas Montalbetti, Aneta J. Przepiorski, Shujie Shi, Shaohu Sheng, Catherine J. Baty, Joseph C. Maggiore, Marcelo D. Carattino, Thitinee Vanichapol, Alan J. Davidson, Neil A. Hukriede, Thomas R. Kleyman
Publikováno v:
American Journal of Physiology-Renal Physiology. 323:F479-F491
Kidney organoids derived from human or rodent pluripotent stem cells have glomerular structures and differentiated/polarized nephron segments. Although there is an increasing understanding of the patterns of expression of transcripts and proteins wit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a43c05793e2fb3fc5d3fba317145db1f
https://doi.org/10.1152/ajprenal.00365.2021
https://doi.org/10.1152/ajprenal.00365.2021