Zobrazeno 1 - 10
of 128
pro vyhledávání: '"Alan J Burns"'
Autor:
Dorit Hockman, Alan J Burns, Gerhard Schlosser, Keith P Gates, Benjamin Jevans, Alessandro Mongera, Shannon Fisher, Gokhan Unlu, Ela W Knapik, Charles K Kaufman, Christian Mosimann, Leonard I Zon, Joseph J Lancman, P Duc S Dong, Heiko Lickert, Abigail S Tucker, Clare V H Baker
Publikováno v:
eLife, Vol 6 (2017)
The evolutionary origins of the hypoxia-sensitive cells that trigger amniote respiratory reflexes – carotid body glomus cells, and ‘pulmonary neuroendocrine cells’ (PNECs) - are obscure. Homology has been proposed between glomus cells, which ar
Externí odkaz:
https://doaj.org/article/90ee98c22520473bb323c934cc72f10b
Autor:
Julie E Cooper, Conor J McCann, Dipa Natarajan, Shanas Choudhury, Werend Boesmans, Jean-Marie Delalande, Pieter Vanden Berghe, Alan J Burns, Nikhil Thapar
Publikováno v:
PLoS ONE, Vol 11, Iss 1, p e0147989 (2016)
Enteric neuropathies are severe gastrointestinal disorders with unsatisfactory outcomes. We aimed to investigate the potential of enteric neural stem cell therapy approaches for such disorders by transplanting mouse enteric neural crest cells (ENCCs)
Externí odkaz:
https://doaj.org/article/0cba20767ae94ba089de9c08d276e72a
Autor:
Weikang Pan, Ahmed A. Rahman, Takahiro Ohkura, Rhian Stavely, Kensuke Ohishi, Christopher Y. Han, Abigail Leavitt, Aki Kashiwagi, Alan J. Burns, Allan M. Goldstein, Ryo Hotta
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-10 (2024)
Abstract Neurointestinal diseases cause significant morbidity and effective treatments are lacking. This study aimes to test the feasibility of transplanting autologous enteric neural stem cells (ENSCs) to rescue the enteric nervous system (ENS) in a
Externí odkaz:
https://doaj.org/article/a79ce412a55e45d297b62f324b8dce20
Autor:
Ellen Binder, Dipa Natarajan, Julie Cooper, Rania Kronfli, Mara Cananzi, Jean-Marie Delalande, Conor McCann, Alan J Burns, Nikhil Thapar
Publikováno v:
PLoS ONE, Vol 10, Iss 3, p e0119467 (2015)
Enteric neural stem cells provide hope of curative treatment for enteric neuropathies. Current protocols for their harvesting from humans focus on the generation of 'neurospheres' from cultures of dissociated gut tissue. The study aims to better unde
Externí odkaz:
https://doaj.org/article/77c9bed1bb21461f8e3d42369247f9e5
Autor:
Ryo Hotta, Ahmed Rahman, Sukhada Bhave, Rhian Stavely, Weikang Pan, Shriya Srinivasan, Geoffrey de Couto, Luis Rodriguez-Borlado, Richard Myers, Alan J. Burns, Allan M. Goldstein
Publikováno v:
Stem Cell Research & Therapy, Vol 14, Iss 1, Pp 1-12 (2023)
Abstract Background Enteric neuropathies, which result from abnormalities of the enteric nervous system, are associated with significant morbidity and high health-care costs, but current treatments are unsatisfactory. Cell-based therapy offers an inn
Externí odkaz:
https://doaj.org/article/3507b616264b4da0a5ab836cf0ab4178
Autor:
Ryo Hotta, Weikang Pan, Sukhada Bhave, Nandor Nagy, Rhian Stavely, Takahiro Ohkura, Kumar Krishnan, Geoffrey de Couto, Richard Myers, Luis Rodriguez-Borlado, Alan J. Burns, Allan M. Goldstein
Publikováno v:
Cell Transplantation, Vol 32 (2023)
The enteric nervous system (ENS) is an extensive network of neurons and glia within the wall of the gastrointestinal (GI) tract that regulates many essential GI functions. Consequently, disorders of the ENS due to developmental defects, inflammation,
Externí odkaz:
https://doaj.org/article/2be94383c769473181d73fdc2d28dfb1
Autor:
John B. Furness, Enie Lei, Billie Hunne, Cameron D. Adams, Alan J. Burns, Jill Wykosky, Therese E. Fazio Coles, Linda J. Fothergill, Juan C. Molero, Ruslan V. Pustovit, Lincon A. Stamp
Publikováno v:
Disease Models & Mechanisms, Vol 16, Iss 6 (2023)
Externí odkaz:
https://doaj.org/article/55ac24c3524e4630becd2935e6965f80
Publikováno v:
Biomolecules, Vol 14, Iss 2, p 229 (2024)
Neurointestinal diseases represent a significant challenge in clinical management with current palliative approaches failing to overcome disease and treatment-related morbidity. The recent progress with cell therapy to restore missing or defective co
Externí odkaz:
https://doaj.org/article/0bda0ee17c174098b16f7b99df051f14
Autor:
Benjamin Jevans, Nicholas D. James, Emily Burnside, Conor J. McCann, Nikhil Thapar, Elizabeth J. Bradbury, Alan J. Burns
Publikováno v:
Stem Cell Research & Therapy, Vol 12, Iss 1, Pp 1-19 (2021)
Abstract Background Spinal cord injury (SCI) presents a significant challenge for the field of neurotherapeutics. Stem cells have shown promise in replenishing the cells lost to the injury process, but the release of axon growth-inhibitory molecules
Externí odkaz:
https://doaj.org/article/3fd43e2b9dbd474895f89c16bfd7d6c7
Autor:
Jean Marie Delalande, Nandor Nagy, Conor J. McCann, Dipa Natarajan, Julie E. Cooper, Gabriela Carreno, David Dora, Alison Campbell, Nicole Laurent, Polychronis Kemos, Sophie Thomas, Caroline Alby, Tania Attié-Bitach, Stanislas Lyonnet, Malcolm P. Logan, Allan M. Goldstein, Megan G. Davey, Robert M. W. Hofstra, Nikhil Thapar, Alan J. Burns
Publikováno v:
Frontiers in Molecular Neuroscience, Vol 15 (2022)
Externí odkaz:
https://doaj.org/article/5d0e10da1fe1437aae823b46ae936c1c