Zobrazeno 1 - 10
of 81
pro vyhledávání: '"Alan J A McBride"'
Autor:
Mara A. C. Maia, Everton B. Bettin, Liana N. Barbosa, Natasha R. de Oliveira, Tiffany T. Bunde, Ana Carolina K. Pedra, Guilherme A. Rosa, Elias E. B. da Rosa, Amilton C. P. Seixas Neto, André A. Grassmann, Johnjoe McFadden, Odir A. Dellagostin, Alan J. A. McBride
Publikováno v:
Frontiers in Cellular and Infection Microbiology, Vol 12 (2022)
Leptospirosis is a neglected disease of man and animals that affects nearly half a million people annually and causes considerable economic losses. Current human vaccines are inactivated whole-cell preparations (bacterins) of Leptospira spp. that pro
Externí odkaz:
https://doaj.org/article/d2d6b69d71924b358ac3d6be79add31e
Autor:
Andre Alex Grassmann, Amilton Clair Pinto Seixas Neto, Andriele Bonemann Madruga, Everton Burlamarque Bettin, Thaís Larré Oliveira, Jessica Dorneles, Alan J. A. McBride, Amanda Silva Hecktheuer, Odir Antônio Dellagostin
Publikováno v:
Applied Microbiology and Biotechnology
Leptospirosis is an emerging infectious disease caused by pathogenic Leptospira spp. A universal vaccine against leptospirosis is likely to require highly conserved epitopes from pathogenic leptospires that are exposed on the bacterial surface and th
Autor:
Neida L Conrad, Flávia W Cruz McBride, Jéssica D Souza, Marcelle M Silveira, Samuel Félix, Karla S Mendonça, Cleiton S Santos, Daniel A Athanazio, Marco A Medeiros, Mitermayer G Reis, Odir A Dellagostin, Alan J A McBride
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 11, Iss 3, p e0005441 (2017)
Neglected tropical diseases, including zoonoses such as leptospirosis, have a major impact on rural and poor urban communities, particularly in developing countries. This has led to major investment in antipoverty vaccines that focus on diseases that
Externí odkaz:
https://doaj.org/article/8b7a1455c19842dfbe3e357bb08f0ac4
Publikováno v:
VITTALLE - Revista de Ciências da Saúde. 32:81-92
Leptospirosis is a neglected infectious disease that affects humans and animals with a higher incidence in the tropics and subtropics. In that context, the aim of this study was to describe the temporal distribution of the epidemiology and sociodemog
Publikováno v:
VITTALLE - Revista de Ciências da Saúde. 32:165-173
Neisseria meningitidis is one of the major etiologic agents of bacterial meningitis and one of the most important causes of invasive bacterial disease worldwide. In Brazil, Invasive meningococcal disease is endemic, predominantly caused by serogroups
Autor:
Odir A. Dellagostin, André A. Grassmann, Caroline Rizzi, Rodrigo A. Schuch, Sérgio Jorge, Thais L. Oliveira, Alan J. A. McBride, Daiane D. Hartwig
Publikováno v:
International Journal of Molecular Sciences, Vol 18, Iss 1, p 158 (2017)
Leptospirosis is a major public health problem with an incidence of over one million human cases each year. It is a globally distributed, zoonotic disease and is associated with significant economic losses in farm animals. Leptospirosis is caused by
Externí odkaz:
https://doaj.org/article/1b6970456fd14e80b008b87361a6a69c
Autor:
Patrícia D Oliveira, Ricardo C Michel, Alan J A McBride, Angelita S Moreira, Rosana F T Lomba, Claire T Vendruscolo
Publikováno v:
PLoS ONE, Vol 8, Iss 5, p e62713 (2013)
The aim of this work was to evaluate the utilization of analysis of the distribution of relaxation time (DRT) using a dynamic light back-scattering technique as alternative method for the determination of the concentration regimes in aqueous solution
Externí odkaz:
https://doaj.org/article/28d62072fe8b4bf49346ae3ecda6f566
Publikováno v:
PLoS ONE, Vol 8, Iss 11, p e81338 (2013)
Bauhinia variegata lectins (BVL-I and BVL-II) are single chain lectins isolated from the plant Bauhinia variegata. Single chain lectins undergo post-translational processing on its N-terminal and C-terminal regions, which determines their physiologic
Externí odkaz:
https://doaj.org/article/e3b05f0870e34fca8011f5cd14b0853f
Autor:
Adenizar D Chagas-Junior, Caroline L R da Silva, Luciane Marieta Soares, Cleiton S Santos, Carlos D C M Silva, Daniel A Athanazio, Mitermayer G dos Reis, Flávia W Cruz McBride, Alan J A McBride
Publikováno v:
PLoS ONE, Vol 7, Iss 2, p e32712 (2012)
A major limitation in the clinical management and experimental research of leptospirosis is the poor performance of the available methods for the direct detection of leptospires. In this study, we compared real-time PCR (qPCR), targeting the lipL32 g
Externí odkaz:
https://doaj.org/article/9f4461fc47f441f989ddc0814cfd7924
Autor:
Carolina Rodrigues Felix, Liana Nunes Barbosa, Alan J. A. McBride, Gabriana R Timm, Bianca S Siedler, Johnjoe McFadden
Publikováno v:
Expert opinion on drug discovery. 15(2)
Introduction: It's been 20 years since the first report of a recombinant vaccine that protected against leptospirosis. Since then, numerous recombinant vaccines have been evaluated; however, no recombinant vaccine candidate has advanced to clinical t