Interferon gamma mediates the reduction of adipose tissue regulatory T cells in human obesity

Autor: David Bradley, Alan J. Smith, Alecia Blaszczak, Dharti Shantaram, Stephen M. Bergin, Anahita Jalilvand, Valerie Wright, Kathleen L. Wyne, Revati S. Dewal, Lisa A. Baer, Katherine R. Wright, Kristin I. Stanford, Bradley Needleman, Stacy Brethauer, Sabrena Noria, David Renton, Joshua J. Joseph, Amy Lovett-Racke, Joey Liu, Willa A. Hsueh

Publikováno v: Nature Communications, Vol 13, Iss 1, Pp 1-12 (2022)

Murine models of obesity suggest that decreases in the adipose tissue regulatory T cell compartment may contribute to insulin resistance, but how this corresponds in the human clinical context is less well understood. Here the authors propose a role

Externí odkaz: https://doaj.org/article/5cf60e1c6bd444d5a39e474ea1128c55

A New Structural Classification Scheme for Dissolved Organic Sulfur in Urban Snow from North China

Autor: Sihui Su, Qiaorong Xie, Alan J. Smith, Yunchao Lang, Wei Hu, Dong Cao, Siyao Yue, Shuang Chen, Jialei Zhu, Yisheng Xu, Nicholle G. A. Bell, Dušan Uhrín, Pingqing Fu

Publikováno v: Su, S, Xie, Q, Smith, A J, Lang, Y, Hu, W, Cao, D, Yue, S, Chen, S, Zhu, J, Xu, Y, Bell, N G A, Uhrín, D & Fu, P 2022, ' A New Structural Classification Scheme for Dissolved Organic Sulfur in Urban Snow from North China ', Environmental Science and Technology Letters, vol. 9, no. 5, pp. 366-374 . https://doi.org/10.1021/acs.estlett.2c00153
Environmental science & technology letters / American Chemical Society

The chemical composition of dissolved organic sulfur in snow is important in understanding the sources and scavenging processes of atmospheric organic matter. Snow samples collected simultaneously from four megacities in North China were analyzed usi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::57ba7e3d1f6c896f5eda45f4a23cc897
https://hdl.handle.net/20.500.11820/c27724ea-2c19-4e42-a888-07f905549c63

Peroxisome proliferator-activated receptor gamma activation reverses adipose tissue regulatory T cell dysfunction

Autor: Alan J Smith, Dharti Shantaram, Joey Liu, Valerie P. Wright, David Bradley, Willa A. Hsueh

Publikováno v: The Journal of Immunology. 206:113.12-113.12

Adipose tissue (AT) regulatory T Cells (Tregs) play an essential role in regulating inflammatory and metabolic responses. Obesity is associated with a decrease in AT Tregs and a corresponding increase in tissue inflammation and systemic insulin resis

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::3c6d13c186ceb8b12118de0d6d74ab93
https://doi.org/10.4049/jimmunol.206.supp.113.12

Zebrafish-Based Discovery of Antiseizure Compounds from the Red Sea: Pseurotin A

Autor: Daniëlle, Copmans, Mostafa, Rateb, Jioji N, Tabudravu, Mercedes, Pérez-Bonilla, Nina, Dirkx, Riccardo, Vallorani, Caridad, Diaz, José, Pérez Del Palacio, Alan J, Smith, Rainer, Ebel, Fernando, Reyes, Marcel, Jaspars, Peter A M, de Witte

Publikováno v: ACS chemical neuroscience. 9(7)

In search for novel antiseizure drugs (ASDs), the European FP7-funded PharmaSea project used zebrafish embryos and larvae as a drug discovery platform to screen marine natural products to identify promising antiseizure hits in vivo for further develo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::25e2cd3816a4655e962d021bb7ae472b
https://pubmed.ncbi.nlm.nih.gov/29672015

Simultaneous detection of positive and negative secondary ions

Autor: Graham A. Cooke, Richard J. Chater, Alan J. Smith

A secondary ion mass spectrometer (SIMS) instrument is described that is configured with two SIMSdetectors that are both low-field extraction, quadrupole-based filters. Secondary ions are generated by sputtering with a liquid-metal ion gallium source

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e30ad47cf0fc4e4e0a966a590e960536
http://hdl.handle.net/10044/1/42038