Zobrazeno 1 - 10
of 36
pro vyhledávání: '"Alan J, Schafer"'
Autor:
Inês Barroso, Jian'an Luan, Rita P. S Middelberg, Anne-Helen Harding, Paul W Franks, Rupert W Jakes, David Clayton, Alan J Schafer, Stephen O'Rahilly, Nicholas J Wareham
Publikováno v:
PLoS Biology, Vol 1, Iss 3 (2003)
Externí odkaz:
https://doaj.org/article/55ef26f3360041eda1fdb0f7c8dc6ba3
Autor:
Inês Barroso, Jian'an Luan, Rita P S Middelberg, Anne-Helen Harding, Paul W Franks, Rupert W Jakes, D Clayton, Alan J Schafer, Stephen O'Rahilly, Nicholas J Wareham
Publikováno v:
PLoS Biology, Vol 1, Iss 1, p E20 (2003)
Type 2 diabetes is an increasingly common, serious metabolic disorder with a substantial inherited component. It is characterised by defects in both insulin secretion and action. Progress in identification of specific genetic variants predisposing to
Externí odkaz:
https://doaj.org/article/0bef25f75ff94ebbbd1add8a483feb7c
Autor:
Paul W. Franks, Stephen O'Rahilly, Nicholas J. Wareham, U. Ekelund, Inês Barroso, Alan J. Schafer, Jian'an Luan, Soren Brage
Publikováno v:
Diabetologia. 50:569-573
The peroxisome proliferator-activated receptor gamma coactivator 1-alpha protein, encoded by the PPARGC1A gene, transcriptionally activates a complex pathway of lipid and glucose metabolism and is expressed primarily in tissues of high metabolic acti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ff4bdaeee2d9de70f3c69243fdbbf9f9
https://doi.org/10.1007/s00125-006-0580-1
https://doi.org/10.1007/s00125-006-0580-1
Autor:
Ulf Ekelund, Stephen O'Rahilly, Manuel Serrano Ríos, Paul W. Franks, Soren Brage, Inês Barroso, Nicholas J. Wareham, Jian'an Luan, Jose Luis Gonzalez Sanchez, Alan J. Schafer
Publikováno v:
Diabetes. 54:2795-2801
Endothelium-derived nitric oxide (NO) facilitates skeletal muscle glucose uptake. Energy expenditure induces the endothelial NO synthase (eNOS) gene, providing a mechanism for insulin-independent glucose disposal. The object was to test 1) the associ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d6102397ffbf2438aff0982bab2ac22b
https://doi.org/10.2337/diabetes.54.9.2795
https://doi.org/10.2337/diabetes.54.9.2795
Autor:
A. Margot Umpleby, Huw Alban Davies, Carlo L. Acerini, Christian Wolfrum, Jenny C Wilson, David B. Dunger, Maria A. Soos, S Schinner, Rachel M. Williams, Justin J. Rochford, Markus Stoffel, Inês Barroso, Stella George, Sarah L. Gray, Stephen O'Rahilly, Nicholas J. Wareham, Alan J. Schafer, Peter R. Murgatroyd, David Barford
Publikováno v:
Science. 304:1325-1328
Inherited defects in signaling pathways downstream of the insulin receptor have long been suggested to contribute to human type 2 diabetes mellitus. Here we describe a mutation in the gene encoding the protein kinase AKT2/PKBβ in a family that shows
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::31a440aea9bff8f35d25446b87b64675
https://doi.org/10.1126/science.1096706
https://doi.org/10.1126/science.1096706
Autor:
Alan J. Schafer, Maria A. Soos, Antonio Vidal-Puig, Aline Meirhaeghe, Jian'an Luan, Stephen O'Rahilly, Lisa Logie, Giles S.H. Yeo, Nicholas J. Wareham, Inês Barroso, Matthias Laudes
Publikováno v:
Diabetes. 53:842-846
The transcription factor sterol regulatory element binding protein (SREBP)-1c is intimately involved in the regulation of lipid and glucose metabolism. To investigate whether mutations in this gene might contribute to insulin resistance, we screened
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::239e540da2343a86c841e94b3227afd0
https://doi.org/10.2337/diabetes.53.3.842
https://doi.org/10.2337/diabetes.53.3.842
Autor:
David B. Savage, Gudrun Ihrke, Maria A. Soos, E. Louise Thomas, K. Meeran, Inês Barroso, Antonio Vidal-Puig, Aline Meirhaeghe, Maura Agostini, Jian'an Luan, Odelia Rajanayagam, Jimmy D. Bell, Stephen O'Rahilly, Dirk Berger, Richard J. Ross, Anne-Helen Harding, Alan J. Schafer, Mark Gurnell, Nicholas J. Wareham, V. Krishna K. Chatterjee, Stella George
Publikováno v:
Nature Genetics. 31:379-384
Impaired insulin action is a key feature of type 2 diabetes and is also found, to a more extreme degree, in familial syndromes of insulin resistance. Although inherited susceptibility to insulin resistance may involve the interplay of several genetic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eb20cdedc514b094248d5ad5a1d3f9b4
https://doi.org/10.1038/ng926
https://doi.org/10.1038/ng926
Autor:
Alan J. Schafer, J. R. Hawkins
Publikováno v:
Nature Biotechnology. 16:33-39
The use of DNA variants in the mapping of the human genome and in the positional cloning of monogenic disease genes is well established. Determining the genetic bases of the more common "multifactorial" diseases, however, presents a major challenge.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1008af5c86ac108359c5ce07a8db601d
https://doi.org/10.1038/nbt0198-33
https://doi.org/10.1038/nbt0198-33
Autor:
Valerie Watiker, William R. Wilcox, Ralph S. Lachman, Alan J. Schafer, Inês Barroso, Gerd Scherer
Publikováno v:
American Journal of Medical Genetics Part A. :110-112
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::126f36c5c0de096eab250c961fbf8ed4
https://doi.org/10.1002/ajmg.a.30650
https://doi.org/10.1002/ajmg.a.30650
Publikováno v:
Annals of the New York Academy of Sciences. 785:137-149
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9dd202bd82b9325f2b2d9b76bd2ffc3b
https://doi.org/10.1111/j.1749-6632.1996.tb56252.x
https://doi.org/10.1111/j.1749-6632.1996.tb56252.x