Výsledky vyhledávání - "Alan J, Green"

A Phase I Clinical Trial of CHT-25 a 131I-Labeled Chimeric Anti-CD25 Antibody Showing Efficacy in Patients with Refractory Lymphoma

Autor: Philip Ross, Peter Amlot, Pei-San Chan, Christopher McNamara, Alan G. Ramsay, T. Andrew Lister, Alessandra Malaroda, Surinder K. Sharma, John R. Buscombe, Anmol Malhotra, Shokri Othman, Richard H. J. Begent, John Violet, Gairin Dancey, Roslyn J. Francis, Nicholas Woodward, Sweta Parker, Alan J. Green, Natalie Griffin

Publikováno v: Clinical cancer research : an official journal of the American Association for Cancer Research. 15(24)

Purpose: There is a need for new treatments for Hodgkin and T-cell lymphoma due to the development of drug resistance in a proportion of patients. This phase I study of radioimmunotherapy used CHT-25, a chimeric antibody to the α-chain of the interl

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3576f9fa8b941a8801d61b10457bb499
https://pubmed.ncbi.nlm.nih.gov/20008855

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A phase I trial of radioimmunotherapy with 131I-A5B7 anti-CEA antibody in combination with combretastatin-A4-phosphate in advanced gastrointestinal carcinomas

Publikováno v: Clinical cancer research : an official journal of the American Association for Cancer Research. 15(13)

Purpose: In preclinical models, radioimmunotherapy with 131I-A5B7 anti–carcinoembryonic antigen (CEA) antibody (131I-A5B7) combined with the vascular disruptive agent combretastatin-A4-phosphate (CA4P) produced cures unlike either agent alone. We c

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fcbbc36929b7b3b91bacfe3e8154b7b7
http://ora.ox.ac.uk/objects/uuid:03bc90af-a61a-4d0e-8bd3-0374177a2972

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A phase I study of single administration of antibody-directed enzyme prodrug therapy with the recombinant anti-carcinoembryonic antigen antibody-enzyme fusion protein MFECP1 and a bis-iodo phenol mustard prodrug

Autor: Clare Cruickshank, John A. Hartley, Berend Tolner, Alan J. Green, Julie Wren, Geoff Boxer, Surinder K. Sharma, A Mayer, Jan Martin, Richard H. J. Begent, Roslyn J. Francis, Caroline J. Springer, Jimmy D. Bell, Kerry A. Chester

Publikováno v: Clinical cancer research : an official journal of the American Association for Cancer Research. 12(21)

Purpose: Antibody-directed enzyme prodrug therapy is a two-stage treatment whereby a tumor-targeted antibody-enzyme complex localizes in tumor for selective conversion of prodrug. The purpose of this study was to establish optimal variables for singl

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aed3680d6afd8a53b5698f90bd1ad4cf
https://pubmed.ncbi.nlm.nih.gov/17085666

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Engineering antibodies for clinical applications in cancer

Autor: A Mayer, Kerry A. Chester, Barbara Pedley, Richard H. J. Begent, Surinder K. Sharma, John Violet, Geoff Boxer, Alan J. Green, Sylvia Nagl, Berend Tolner

Publikováno v: Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine. 25(1-2)

The 'magic bullet' concept predicted over a century ago that antibodies would be used to target cancer therapy. Since then initial problems that were related to specificity, purity and immungenicity of antibody-based reagents have slowly been overcom

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6189cb0b0a610276bde59893a143077a
https://pubmed.ncbi.nlm.nih.gov/15192316

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Analysis of the regional uptake of radiolabeled deoxyglucose analogs in human tumor xenografts

Autor: Jason L J, Dearling, Aiden A, Flynn, Julie, Sutcliffe-Goulden, Ingrid A, Petrie, Robert, Boden, Alan J, Green, Geoffrey M, Boxer, Richard H J, Begent, R Barbara, Pedley

Publikováno v: Journal of nuclear medicine : official publication, Society of Nuclear Medicine. 45(1)

It has been shown in vitro that the cell uptake of (18)F-FDG, a tracer of glucose metabolism, increases under hypoxia. This is consistent with increased glycolytic metabolism. We have previously shown that in ischemic heart ex vivo the rates of uptak

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::a96d094d7f7894901554f608fcbd6c80
https://pubmed.ncbi.nlm.nih.gov/14734681

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Optimizing radioimmunotherapy by matching dose distribution with tumor structure using 3D reconstructions of serial images

Autor: AA Flynn, Geoffrey M. Boxer, Alan J. Green, Robert Boden, Richard H. J. Begent, R. Barbara Pedley

Publikováno v: Cancer biotherapyradiopharmaceuticals. 16(5)

The biological effect of radioimmunotherapy (RIT) is most commonly assessed in terms of the absorbed radiation dose. In tumor, conventional dosimetry methods assume a uniform radionuclide and calculate a mean dose throughout the tumor. However, the v

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d9d9f8875c5f6b3bc29ce09dfe610761
https://pubmed.ncbi.nlm.nih.gov/11776756

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A novel technique, using radioluminography, for the measurement of uniformity of radiolabelled antibody distribution in a colorectal cancer xenograft model

Autor: Geoffrey M Boxer, Richard H. J. Begent, Aiden A Flynn, R. Barbara Pedley, Alan J. Green, Joanne L. Casey

Publikováno v: International journal of radiation oncology, biology, physics. 43(1)

Purpose: Radioimmunotherapy of cancer employs an antitumour antibody to carry a radionuclide selectively to deposits of cancer. Conventional dose estimates, based on the Medical Internal Radiation Dose (MIRD) formulation, assume uniform distribution

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9ac5bce93a9840071af309331a85180a
https://pubmed.ncbi.nlm.nih.gov/9989525

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An overview of imaging techniques and physical aspects of treatment planning in radioimmunotherapy

Autor: Alan J. Green, Kenneth F. Koral, Ronald J. Jaszczak, George T.Y. Chen, Peter K. Leichner, John C. Roeske

Publikováno v: Medical physics. 20(2 Pt 2)

Planar and tomographic imaging techniques and methods of treatment planning in clinical radioimmunotherapy are reviewed. In clinical trials, the data needed for dosimetry and treatment planning are, in most cases, obtained from noninvasive imaging pr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ffc958c367a7fb3f4d15c6d3ffdf37ed
https://pubmed.ncbi.nlm.nih.gov/8492765

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