Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Alan Ironmonger"'
Autor:
Hugh Clark, Peter Szeto, Robert N. Bream, Alan Ironmonger, John D. Hayler, Nadine Mc Cleary, Alastair J. Roberts, Edney Dean David, Catherine Priestley, Michael R. Webb, Antal Harsanyi, Katherine Wheelhouse, Philip J. Rushworth, Natalie Phillips
Publikováno v:
Organic Process Research & Development. 25:529-540
This paper describes the development of an improved and scalable method for the manufacture of nemiralisib, a phosphatidylinositol-3-kinase delta inhibitor. Incorporation of three consecutive catal...
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a4d2497481e3451bd75cd43c57a09320
https://doi.org/10.1021/acs.oprd.0c00486
https://doi.org/10.1021/acs.oprd.0c00486
Autor:
Erica Vit, Jerome F. Hayes, Francois-Rene Alexandre, Cyril B. Dousson, Christophe Claude Parsy, David D. Pascoe, Catherine Caillet, Marie-Pierre Lioure, Neil Hodnett, Elodie Rosinovsky, John Edward Richardson, Guillaume Bret, Stéphanie Bot, Agnès Amador, Gary T. Borrett, Bernadette Choudary, Arlène Roland, Daniel Da Costa, Alan Ironmonger, John D. Hayler, Augustine Ochen, Séverine Bonaric, David Colclough, Richard K. Bellingham
Publikováno v:
Organic Process Research & Development. 22:200-206
A new and improved synthetic route to an intermediate in the synthesis of the phosphinate ester GSK2248761A is described. In the key step, we describe the first process-scale example of a palladium-catalyzed phosphorus–carbon coupling to give the e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e17aba0e5462710cfa14470fea5b10eb
https://doi.org/10.1021/acs.oprd.7b00356
https://doi.org/10.1021/acs.oprd.7b00356
Autor:
David D. Pascoe, John D. Hayler, Alistair Stewart, Erica Vit, Jingyang Wang, Etridge Stephen K, Celine Bret, Alan Ironmonger, Elaine Smith, Neil Hodnett, Jerome F. Hayes, Adel Moussa, Benjamin Alexander Mayes, Jonathan Stanway
Publikováno v:
Organic Process Research & Development. 22:207-211
Amidation of indole 2-carboxylate 1 with ammonia gas via the imidazolide 2 gave GSK2248761A API 3, which was in development for the treatment of HIV. Three significant impurities, namely the phosphinic acid 4, the N-acyl urea 8, and the indoloyl carb
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5d738e029ca3bcdc1a2aa848d8a5c8d5
https://doi.org/10.1021/acs.oprd.7b00357
https://doi.org/10.1021/acs.oprd.7b00357
Autor:
Fiona Slater, Francois-Rene Alexandre, Matthew G. Unthank, Pete Szeto, Catherine Caillet, Mark R. Shipton, Cyril B. Dousson, Alan Ironmonger
Publikováno v:
Tetrahedron Letters. 59:2154-2156
A highly diastereoselective chloride-mediated dynamic kinetic resolution at phosphorus has been developed to access a key intermediate in the synthesis of GSK2248761A. This procedure utilises a soluble chloride source and a cheap readily available ch
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b150d08626f012a84798f642718a7924
https://doi.org/10.1016/j.tetlet.2018.04.018
https://doi.org/10.1016/j.tetlet.2018.04.018
Autor:
Jonathan P. Graham, Mahesh J. Sanganee, Duncan R. Thompson, Catherine Priestley, Michael R. Webb, Thoralf Hartwig, Lesley A. Senior, Alan Ironmonger, Peter Hamilton
Publikováno v:
Organic Process Research & Development. 19:236-243
The development of a hydrogenation process and subsequent isolation for an intermediate in the manufacture of an active pharmaceutical ingredient is described. In-line process analytical technology (PAT) approaches were applied to gain process unders
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d392000352852041554461fb74ee3061
https://doi.org/10.1021/op500285x
https://doi.org/10.1021/op500285x
Autor:
Stephen P. Thomas, G. Usherwood Sloan, Alan Ironmonger, Ming-Ming Tran, Jennifer E. Nelson, Alistair J. MacNair
Publikováno v:
MacNair, A J, Ming-Ming Tran, N V, Nelson, J E, Sloan, G U, Ironmonger, A & Thomas, S P 2014, ' Iron-catalysed, general and operationally simple formal hydrogenation using Fe(OTf)(3) and NaBH4 ', Organic & Biomolecular chemistry, vol. 12, no. 28, pp. 5082-5088 . https://doi.org/10.1039/c4ob00945b
An operationally simple and environmentally benign formal hydrogenation protocol has been developed using highly abundant iron (III) salts and an inexpensive, bench stable, stoichiometric reductant, NaBH4, in ethanol, under ambient conditions. This r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4978d2e643f36334800d2d2e3f778fbb
https://doi.org/10.1039/c4ob00945b
https://doi.org/10.1039/c4ob00945b
Publikováno v:
Organic Letters. 15:910-913
ortho-Arylation of ortho-substituted benzoic acids is a challenging process due to the tendency of the reaction products toward Pd-catalyzed protodecarboxylation. A simple method for preventing decarboxylation in sterically hindered benzoic acids is
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1095c549f330bf672876a97d7ae5466d
https://doi.org/10.1021/ol400065j
https://doi.org/10.1021/ol400065j
Autor:
Gary S. Nichol, Alan Ironmonger, Clément R. P. Millet, Stephen P. Thomas, Alistair J. MacNair
Publikováno v:
Macnair, A J, Millet, C R P, Nichol, G S, Ironmonger, A & Thomas, S P 2016, ' Markovnikov-Selective, Activator-Free Iron-Catalyzed Vinylarene Hydroboration ', ACS Catalysis, pp. 7217-7221 . https://doi.org/10.1021/acscatal.6b02281
Two series of structurally related alkoxy-tethered NHC iron(II) complexes have been developed as catalysts for the regioselective hydroboration of alkenes. Significantly, Markonikov-selective alkene hydroboration with HBpin has been controllably achi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::70a49cfa41e6000ef876a7712374dc6e
https://hdl.handle.net/20.500.11820/ca1dc2d8-7d12-49e8-93fe-e61d1e26b0fb
https://hdl.handle.net/20.500.11820/ca1dc2d8-7d12-49e8-93fe-e61d1e26b0fb
Application of a novel palladium-catalysed stereoselective arylative allene spirocyclisation cascade as the key step for the construction of the ACE tricyclic core of manzamine A is described.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3b769a5d354095ad0c203681450816a4
https://ora.ox.ac.uk/objects/uuid:ad108a8a-a387-40a7-95d7-3f54c57c5301
https://ora.ox.ac.uk/objects/uuid:ad108a8a-a387-40a7-95d7-3f54c57c5301
Publikováno v:
ChemInform. 46
A new method for the Pd-catalyzed C—H coupling of a variety of classes of substrates such as benzoic acids, benzamides, 2-phenylpyridines, benzoquinolines, indoles, thiophenes, polyfluorobenzenes, and 8-methylquinolines with diverse substituted iod
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fc81c3d45f7d6a646a7844d78bab6fca
https://doi.org/10.1002/chin.201504046
https://doi.org/10.1002/chin.201504046