Zobrazeno 1 - 5
of 5
pro vyhledávání: '"Alan I Lee"'
Autor:
Alan I. Lee, James P. Brody
Publikováno v:
Current Pharmaceutical Biotechnology. 6:415-425
Although the structure of an enzyme is often depicted as static, it is dynamic. Hence, a population of chemically identical enzymes has not one, but a distribution of structures at any moment in time. Does this have an effect on the activity of the e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b6f1b92778cd184a459201e1c5d96709
https://doi.org/10.2174/138920105775159331
https://doi.org/10.2174/138920105775159331
Autor:
Angela T. Hahn, Tobias Meyer, Richard O. Burney, Joshua T. Jones, Denise E. Leong, Alan I Lee, Mylene W.M. Yao
Publikováno v:
Cell cycle (Georgetown, Tex.). 6(18)
High content cell-based genetic and small molecule library screens are powerful strategies in drug discovery and investigations of disease mechanisms. We report that primary cells derived from a transgenic mouse model expressing a fluorescence mitosi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d87b79cc7c39d8ed6cf0e49091ba422a
https://pubmed.ncbi.nlm.nih.gov/17881898
https://pubmed.ncbi.nlm.nih.gov/17881898
Autor:
James P. Brody, Alan I. Lee
Publikováno v:
SPIE Proceedings.
A population of identical proteins has the same amino acid sequence, but there may be subtle differences in local folding that lead to variations in activity. Single molecule studies allow us to understand these subtle differences. Single molecule ex
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9a1ae50a74b491920ba5327473f115a4
https://doi.org/10.1117/12.585110
https://doi.org/10.1117/12.585110
Autor:
James P. Brody, Alan I. Lee
Publikováno v:
Biophysical journal. 88(6)
Single-molecule studies allow the study of subtle activity differences due to local folding in proteins, but are time consuming and difficult because only a few molecules are observed in one experiment. We developed an assay where we can simultaneous
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1e1a8c29c0b56dc11cd6b31561ea4f8c
https://pubmed.ncbi.nlm.nih.gov/15764670
https://pubmed.ncbi.nlm.nih.gov/15764670
Publikováno v:
Lab on a Chip; Jul2004, Vol. 4 Issue 4, p292-298, 7p