Zobrazeno 1 - 8 of 8 pro vyhledávání: '"Alan Hastings Drummond"'
1
The combination of HDAC and aminopeptidase inhibitors is highly synergistic in myeloma and leads to disruption of the NFκB signalling pathway
Autor: Faith E. Davies, Leon Hooftman, Brian A Walker, Lauren I. Aronson, David Krige, Lei Zhang, Emma L. Davenport, Gareth J. Morgan, Alan Hastings Drummond, Emma M. Smith
Publikováno v: Oncotarget
// Emma M. Smith 1 , Lei Zhang 1 , Brian A. Walker 1 , Emma L. Davenport 1 , Lauren I. Aronson 1 , David Krige 2 , Leon Hooftman 2 , Alan H. Drummond 2 , Gareth J. Morgan 1 and Faith E. Davies 1 1 Haemato-Oncology Research Unit, Division of Molecular
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::972a6a0a493a35d3210c9e04aee5dcc8
http://europepmc.org/articles/PMC4627310
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2
Drug Targeting to Monocytes and Macrophages Using Esterase-Sensitive Chemical Motifs
Autor: Lindsay Bawden, Deborah Brotherton, Vanessa L. Clark, Richard Testar, Mcdermott Joanne, David Festus Charles Moffat, Yvonne McGovern, Stéphane Pintat, Graham M. A. Wells, Alan Hastings Drummond, Sanjay R. Patel, Alan H. Davidson, Jo Owen, Stephen Davies, Sam Bryant, David Krige, Andrew J. Belfield, Valérie Legris, Lindsey Ann Needham, Elisabeth A. Bone, Francesca Ann Day, Michael Hugh Charlton, A. Donald
Publikováno v: Journal of Pharmacology and Experimental Therapeutics. 339:132-142
The therapeutic and toxic effects of drugs are often generated through effects on distinct cell types in the body. Selective delivery of drugs to specific cells or cell lineages would, therefore, have major advantages, in particular, the potential to
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::99452f8f86d8124b12871827c8e5d797
https://doi.org/10.1124/jpet.111.183640
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3
The synthesis and biological evaluation of non-peptidic matrix metalloproteinase inhibitors
Autor: John S. Ward, Rory Dodd, Paul F. Courtney, Michelle L. Ricketts, Paul Beckett, Richard S. Todd, Mark Whittaker, Lisa M. Pratt, Fionna M. Martin, Stephen John Davies, Claire L. Bellamy, Sanjay Patel, Alan Hastings Drummond, Andrew R. Tuffnell
Publikováno v: Bioorganicmedicinal chemistry letters. 9(19)
Novel sulfonamide matrix metalloproteinase inhibitors of general formula (9) were synthesised by a route involving a stereoselective conjugate addition reaction. Enzyme selectivity was found to be dependant on the nature of the sulfonamide substituen
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fc014661045005cbd2a401be0e06118f
https://pubmed.ncbi.nlm.nih.gov/10522712
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4
Pathways of dephosphorylation of 1-D-myo-inositol 1,4,5-trisphosphate in GH3 pituitary tumor cells
Autor: Alan Hastings Drummond, Fernanda Ruiz-Larrea
Publikováno v: Biochimica et biophysica acta. 1178(1)
Previous work in [ 3 H]inositol-labelled GH3 pituitary tumor cells stimulated with thyrotropin-releasing hormone (TRH) reported the existence of at least ten distinct [ 3 H]inositol-containing substances which were identified as different inositol mo
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ed4ce7a9ab357d232c2b12799467083c
https://pubmed.ncbi.nlm.nih.gov/8392378
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5
Inhibition of HDACs and Aminopeptidases Is Highly Synergistic in Myeloma Cells Resulting in Cell Death Via the Upregulation of BIRC3, a Key Mediator of NF-KappaB Signalling
Autor: Alan Hastings Drummond, David Krige, Leon Hooftman, Brian A Walker, Emma M. Smith, Lauren I. Aronson, Emma L. Davenport, Gareth J. Morgan, Faith E. Davies
Publikováno v: Blood. 114:607-607
Abstract 607 Myeloma cells rely on a number of mechanisms to maintain their survival, including the silencing of genes that would normally check uncontrolled proliferation and lead to apoptosis. Epigenetic alterations such as histone deacetylation co
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::f9eaef0d67712ca8fbce87c14c7fb89a
https://doi.org/10.1182/blood.v114.22.607.607
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6
The interaction of lithium ions with inositol lipid signalling systems
Autor: Alan Hastings Drummond, Lesley A. Joels, Phil. J. Hughes
Publikováno v: Biochemical Society Transactions. 15:32-35
There is now a growing consensus that hormones and neurotransmitters, in stimulating or inhibiting cellular function, produce their characteristic changes by utilizing a relatively small number of general receptor transduction systems. One such mecha
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::179864623f478f115e9a92e6bbc55f29
https://doi.org/10.1042/bst0150032
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7
Lithium and inositol lipid-linked signalling mechanisms
Autor: Alan Hastings Drummond
Publikováno v: Trends in Pharmacological Sciences. 8:129-133
Lithium has long been used in the treatment of manic disorders. Although it is a mainstay of psychiatric therapeutics, it has a very narrow therapeutic index and its acute toxicity is confined almost exclusively to the CNS. The mechanism of action of
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::3d9660d5789725170adba8fbafc1dbef
https://doi.org/10.1016/0165-6147(87)90181-7
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