Zobrazeno 1 - 10
of 29
pro vyhledávání: '"Alan Hair"'
Autor:
Narissa Parry, Caroline Busch, Victoria Aßmann, Jennifer Cassels, Alan Hair, G. Vignir Helgason, Helen Wheadon, Mhairi Copland
Publikováno v:
Cell Death Discovery, Vol 8, Iss 1, Pp 1-13 (2022)
Abstract Dysregulation of the BCL-2 family is implicated in protecting chronic myeloid leukemia (CML) cells from intracellular damage and BCR::ABL1-inhibition with tyrosine kinase inhibitors (TKIs) and may be a viable therapeutic target in blast phas
Externí odkaz:
https://doaj.org/article/c29e35dfaaa141d8b99d7b68e062919f
Publikováno v:
PLoS Genetics, Vol 7, Iss 7, p e1002175 (2011)
Genomic maps of chromatin modifications have provided evidence for the partitioning of genomes into domains of distinct chromatin states, which assist coordinated gene regulation. The maintenance of chromatin domain integrity can require the setting
Externí odkaz:
https://doaj.org/article/15b37b97e196453a98e3f89a65880e81
Autor:
Jacqueline Dickson, Humaira Gowher, Ruslan Strogantsev, Miklos Gaszner, Alan Hair, Gary Felsenfeld, Adam G West
Publikováno v:
PLoS Genetics, Vol 6, Iss 1, p e1000804 (2010)
There is growing consensus that genome organization and long-range gene regulation involves partitioning of the genome into domains of distinct epigenetic chromatin states. Chromatin insulator or barrier elements are key components of these processes
Externí odkaz:
https://doaj.org/article/39dbccdbc4e343b4923ed8cdbf91d599
Autor:
Mansi Shah, Cassie J. Clarke, Anthony D. Whetton, G. Vignir Helgason, Mark Aspinall-O'Dea, Lorna Jackson, Ravi Bhatia, Gustavo Leone, Tessa L. Holyoake, Sheela A. Abraham, Lisa E. M. Hopcroft, Kamil R. Kranc, Laura Park, Alan Hair, Amy Sinclair, Francesca Pellicano, Mary T. Scott
Publikováno v:
Pellicano, F, Park, L, Hopcroft, L E M, Shah, M, Jackson, L, Scott, M T, Clarke, C J, Sinclair, A, Abraham, S A, Hair, A, Helgason, G V, Aspinall-O’Dea, M, Bhatia, R, Leone, G, Kranc, K, Whetton, A D & Holyoake, T L 2018, ' Hsa-mir183/EGR1-mediated regulation of E2F1 is required for CML stem/progenitor cell survival ', Blood . https://doi.org/10.1182/blood-2017-05-783845
Chronic myeloid leukemia (CML) stem/progenitor cells (SPCs) express a transcriptional program characteristic of proliferation, yet can achieve and maintain quiescence. Understanding the mechanisms by which leukemic SPCs maintain quiescence will help
Autor:
Alan Hair, Tessa L. Holyoake, Francesca Pellicano, Alison M. Michie, Heather G. Jørgensen, Jennifer Cassels, Anuradha Tarafdar, David Vetrie, Paolo Gallipoli, Lisa E. M. Hopcroft, Koorosh Korfi
Publikováno v:
Blood. 129(2)
Targeting the fusion oncoprotein BCR-ABL with tyrosine kinase inhibitors has significantly affected chronic myeloid leukemia (CML) treatment, transforming the life expectancy of patients; however the risk for relapse remains, due to persistence of le
Objective To ascertain if direct measurement of the size of common bile duct stones (CBD) on magnetic resonance cholangio-pancreatography (MRCP) can be used to predict the likelihood of a positive endoscopic retrograde cholangio-pancreatography (ERCP
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::42fceb50b37286c23d86bb774391b810
https://strathprints.strath.ac.uk/55569/1/Reid_etal_TS2015_size_of_common_bile_duct_stones_on_mrcp_predicts_likelihood.pdf
https://strathprints.strath.ac.uk/55569/1/Reid_etal_TS2015_size_of_common_bile_duct_stones_on_mrcp_predicts_likelihood.pdf
Autor:
Alan Hair, Yegor S. Vassetzky
Publikováno v:
Journal of Cellular Biochemistry. 102:1140-1148
The size of the DNA loop containing the Xenopus laevis somatic 5S RNA gene cluster has been estimated using a simple, precise and sensitive method that we have developed for use on any tandemly arrayed DNA repeat region, and was found to increase dur
Publikováno v:
Critical Reviews in Eukaryotic Gene Expression. 14:79-88
The nucleus is a highly organized solid-state system, rigid and flexible at the same time, where enzymes are organized in complex processing factories. This is achieved by the organization of nuclear DNA into territories and domains, which allow comp
Autor:
Carol-Ann Courtney, Michael Serpell, Caron Paterson, Paul G. Horgan, David Young, Alan Hair, Sudhir Kumar, Ian Ford, Keith Millar, Andrew Walker, Patrick J. O'Dwyer
Publikováno v:
Annals of Surgery. 237:574-579
To compare patient outcome following repair of a primary groin hernia under local (LA) or general anesthesia (GA) in a randomized clinical trial.LA hernia repair is thought to be safer for patients, causes less postoperative pain, cost less, and is a
Autor:
Alan Hair, Andrew Alabi
Publikováno v:
Pancreatology. 12:e18-e20