Tracking genomic cancer evolution for precision medicine: the lung TRACERx study.

Autor: Mariam Jamal-Hanjani, Alan Hackshaw, Yenting Ngai, Jacqueline Shaw, Caroline Dive, Sergio Quezada, Gary Middleton, Elza de Bruin, John Le Quesne, Seema Shafi, Mary Falzon, Stuart Horswell, Fiona Blackhall, Iftekhar Khan, Sam Janes, Marianne Nicolson, David Lawrence, Martin Forster, Dean Fennell, Siow-Ming Lee, Jason Lester, Keith Kerr, Salli Muller, Natasha Iles, Sean Smith, Nirupa Murugaesu, Richard Mitter, Max Salm, Aengus Stuart, Nik Matthews, Haydn Adams, Tanya Ahmad, Richard Attanoos, Jonathan Bennett, Nicolai Juul Birkbak, Richard Booton, Ged Brady, Keith Buchan, Arrigo Capitano, Mahendran Chetty, Mark Cobbold, Philip Crosbie, Helen Davies, Alan Denison, Madhav Djearman, Jacki Goldman, Tom Haswell, Leena Joseph, Malgorzata Kornaszewska, Matthew Krebs, Gerald Langman, Mairead MacKenzie, Joy Millar, Bruno Morgan, Babu Naidu, Daisuke Nonaka, Karl Peggs, Catrin Pritchard, Hardy Remmen, Andrew Rowan, Rajesh Shah, Elaine Smith, Yvonne Summers, Magali Taylor, Selvaraju Veeriah, David Waller, Ben Wilcox, Maggie Wilcox, Ian Woolhouse, Nicholas McGranahan, Charles Swanton

Publikováno v: PLoS Biology, Vol 12, Iss 7, p e1001906 (2014)

The importance of intratumour genetic and functional heterogeneity is increasingly recognised as a driver of cancer progression and survival outcome. Understanding how tumour clonal heterogeneity impacts upon therapeutic outcome, however, is still an

Externí odkaz: https://doaj.org/article/8c969701acb64396b9868a4b3806e9e1

Tracking genomic cancer evolution for precision medicine: The Lung TRACERx Study

Autor: Salli Muller, Karl S. Peggs, David A. Waller, Elza C de Bruin, Natasha Iles, Magali Taylor, Helen E. Davies, Leena Dennis Joseph, Matthew G Krebs, David Lawrence, Gerald Langman, Maggie Wilcox, Alan Hackshaw, Fiona H Blackhall, Jonathan Bennett, Mairead MacKenzie, Richard Booton, Haydn Adams, Seema Shafi, Daisuke Nonaka, Yenting Ngai, Sam M. Janes, Gary Middleton, Jacqueline A Shaw, Ged Brady, John Le Quesne, Ian Woolhouse, Mariam Jamal-Hanjani, Jason F. Lester, Iftekhar Khan, Tanya Ahmad, Mahendran Chetty, Martin Forster, Richard Mitter, Madhav Djearman, Charles Swanton, Joy Millar, Andrew Rowan, Sean W. Smith, Keith Buchan, A R Denison, Nicolai Juul Birkbak, Nik Matthews, Selvaraju Veeriah, Sergio A. Quezada, Dean A. Fennell, Hardy Remmen, Aengus Stuart, Catrin Pritchard, Nirupa Murugaesu, Malgorzata Kornaszewska, Elaine Smith, Siow Ming Lee, Nicholas McGranahan, Arrigo Capitano, Babu Naidu, Caroline Dive, Marianne Nicolson, Rajesh Shah, Richard Attanoos, Yvonne Summers, Bruno Morgan, Stuart Horswell, Mark Cobbold, Ben Wilcox, Keith M. Kerr, Tom Haswell, Philip A.J. Crosbie, Jacki Goldman, Max Salm, Mary Falzon

Publikováno v: Jamal-Hanjani, M, Hackshaw, A, Ngai, Y, Shaw, J, Dive, C, Quezada, S, Middleton, G, de Bruin, E, Le Quesne, J, Shafi, S, Falzon, M, Horswell, S, Blackhall, F, Khan, I, Janes, S, Nicolson, M, Lawrence, D, Forster, M, Fennell, D, Lee, S-M, Lester, J, Kerr, K, Muller, S, Iles, N, Smith, S, Murugaesu, N, Mitter, R, Salm, M, Stuart, A, Matthews, N, Adams, H, Ahmad, T, Attanoos, R, Bennett, J, Birkbak, N J, Booton, R, Brady, G, Buchan, K, Capitano, A, Chetty, M, Cobbold, M, Crosbie, P, Davies, H, Denison, A, Djearman, M, Goldman, J, Haswell, T, Joseph, L, Kornaszewska, M, Krebs, M, Langman, G, MacKenzie, M, Millar, J, Morgan, B, Naidu, B, Nonaka, D, Peggs, K, Pritchard, C, Remmen, H, Rowan, A, Shah, R, Smith, E, Summers, Y, Taylor, M, Veeriah, S, Waller, D, Wilcox, B, Wilcox, M, Woolhouse, I, McGranahan, N & Swanton, C 2014, ' Tracking Genomic Cancer Evolution for Precision Medicine: The Lung TRACERx Study ', P L o S Biology, vol. 12, no. 7, e1001906 . https://doi.org/10.1371/journal.pbio.1001906
PLoS Biology, Vol 12, Iss 7, p e1001906 (2014)
PLoS Biology

TRACERx, a prospective study of patients with primary non-small cell lung cancer, aims to map the genomic landscape of lung cancer by tracking clonal heterogeneity and tumour evolution from diagnosis to relapse.
The importance of intratumour gen

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a78f6cf4fa6457fa6bd2f2cbcde6710c
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