Zobrazeno 1 - 10
of 24
pro vyhledávání: '"Alan H. Stokes"'
Autor:
Saaussan Madi, Fang Xie, Kamyar Farhangi, Chih-Yang Hsu, Shih-Hsun Cheng, Tolulope Aweda, Bhasker Radaram, Stephanie Slania, Tammy Lambert, Mary Rambo, Tina Skedzielewski, Austin Cole, Valeriia Sherina, Shannon McKearnan, Hoang Tran, Hasan Alsaid, Minh Doan, Alan H. Stokes, Derek T. O’Hagan, Giulietta Maruggi, Sylvie Bertholet, Stéphane T. Temmerman, Russell Johnson, Beat M. Jucker
Publikováno v:
Frontiers in Immunology, Vol 13 (2023)
The goal of this study was to utilize a multimodal magnetic resonance imaging (MRI) and positron emission tomography (PET) imaging approach to assess the local innate immune response in skeletal muscle and draining lymph node following vaccination in
Externí odkaz:
https://doaj.org/article/f8cb07fbb3844bfdbcb71445fb51ca9e
Autor:
Douglas A. Donahue, Cristina Ballesteros, Giulietta Maruggi, Christiana Glover, Michael A. Ringenberg, Miriam Marquis, Nawel Ben Abdeljelil, Asma Ashraf, Luis-Alexander Rodriguez, Alan H. Stokes
Publikováno v:
International Journal of Toxicology. 42:37-49
Vaccines containing mRNA with the capacity to self-amplify represent an alternative to the mRNA vaccines that came to prominence during the COVID-19 pandemic. To gain further insights on the safety profile of self-amplifying mRNA- (SAM-) vaccines, th
Autor:
Giulietta Maruggi, Corey P. Mallett, Jason W. Westerbeck, Tiffany Chen, Giuseppe Lofano, Kristian Friedrich, Lin Qu, Jennifer Tong Sun, Josie McAuliffe, Amey Kanitkar, Kathryn T. Arrildt, Kai-Fen Wang, Ian McBee, Deborah McCoy, Rebecca Terry, Alison Rowles, Maia Araujo Abrahim, Michael A. Ringenberg, Malcolm J. Gains, Catherine Spickler, Xuping Xie, Jing Zou, Pei-Yong Shi, Taru Dutt, Marcela Henao-Tamayo, Izabela Ragan, Richard A. Bowen, Russell Johnson, Sandra Nuti, Kate Luisi, Jeffrey B. Ulmer, Ann-Muriel Steff, Rashmi Jalah, Sylvie Bertholet, Alan H. Stokes, Dong Yu
Publikováno v:
Molecular Therapy
RNA vaccines have demonstrated efficacy against SARS-CoV-2 in humans and the technology, is being leveraged for rapid emergency response. In this report, we assessed immunogenicity, and, for the first time, toxicity, biodistribution and protective ef
Autor:
Alan H. Stokes, Camille Planty, Johanne Pion, Philippe Ancian, Alexandra Rogue, Carine Bansard, Jérémy Silvano, Dominique Papineau, Nawel Ben Abdeljelil, Giulietta Maruggi, Haifeng Song, Catherine Spickler, Karine Blouin, Guillaume Dubois, Luis-Alexander Rodriguez, Judith Baumeister, Ann-Muriel Steff, Eric Destexhe
Publikováno v:
INTERNATIONAL JOURNAL OF TOXICOLOGY, 41, 263-275
Respiratory syncytial virus (RSV) is a leading cause of acute lower respiratory tract infections (LRTI) in infants, and toddlers and vaccines are not yet available. A pediatric RSV vaccine (ChAd155-RSV) is being developed to protect infants against R
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::43d41451c502ad2fec400cba9956b9ee
http://hdl.handle.net/20.500.12470/2779
http://hdl.handle.net/20.500.12470/2779
Autor:
Ornella Binazon, Marie-Noëlle Donner, Alan H. Stokes, Vimala Vemireddi, Luis-Alexander Rodriguez, Daniel E Fisher, Lorraine M. Posobiec, Jeffrey H. Charlap, Mary K. Ziejewski, Niraj Tripathi, Ritankar Majumdar, Payal Khanna Weiss, Judith Baumeister, Kelle Franklin, Badiaa Bouzya, Michael Alan Ringenberg
Publikováno v:
International journal of toxicology. 40(2)
Respiratory syncytial virus (RSV) is a leading cause of acute lower respiratory tract infections, and vaccines are needed to treat young children and older adults. One of GSK’s candidate vaccines for RSV contains recombinant RSVPreF3 protein mainta
Autor:
Neal F. Cariello, Heidi M. Colton, Holly L. Jordan, Brenda Faiola, Alan H. Stokes, Brian R. Berridge, Lawrence Yoon, J. Greg Falls
Publikováno v:
International Journal of Toxicology. 34:151-161
Cardiovascular (CV) safety concerns are among the leading causes of compound attrition in drug development. This work describes a strategy of applying novel end points to a 7-day rodent study to increase the opportunity to detect and characterize CV
Autor:
Daniel C. Kemp, David Bailey, James R. Hailey, Alan H. Stokes, Brenda Faiola, Randy E. Brown, Christine L. Merrill, Holly L. Jordan
Publikováno v:
International Journal of Toxicology. 32:189-197
When conventional vehicles (eg, methylcellulose and water) impart inadequate physical, chemical, and/or biological properties for proper toxicological assessment of test article formulations, nonconventional vehicles may be considered. Often toxicity
Autor:
Brian R. Berridge, Malcolm York, A. Casartelli, Kimberly Roland, Rick R. Adler, Alan H. Stokes, Rhiannon C. Davies, Patrizia Cristofori, Federica Crivellente, Carie L. Kimbrough, Franck Chanut, Rick Hailey, Holly L. Jordan, Jan Klapwijk, Angela Hughes-Earle, Heath C. Thomas
Publikováno v:
Toxicologic Pathology. 41:1126-1136
Cardiovascular safety signals in nonclinical studies remain among the main reasons for drug attrition during pharmaceutical research and development. Drug-induced changes can be functional and/or associated with morphological alterations in the norma
Autor:
Paul Butkerait, Wolfgang Beck, Kent E. Vrana, James A. Daunais, Michael D. Gershon, Yimei Xu, Janina Altman, Alan H. Stokes, Hadassah Tamir, Bernd Kayser
Publikováno v:
Journal of Neurochemistry. 74:2067-2073
Tryptophan hydroxylase (TPH) is the initial and rate-limiting enzyme in serotonin biosynthesis. The enzyme activity is dependent on molecular oxygen, a tetrahydropterin cosubstrate, and ferrous iron. The present study demonstrates that TPH is inhibit
Autor:
Sundeep A. Chandra, Christine L. Merrill, Richard A. Peterson, Kristina DeSmet, David H. Melich, Katherine Mellon-Kusibab, Rick R. Adler, Alan H. Stokes, Rick Hailey, Sylvia Furst
Publikováno v:
Toxicologic pathology. 43(4)
The field of dermal toxicity continues to evolve in order to accurately predict dermal (and systemic) responses in humans to topically applied chemicals. Although the testing methods have undergone extensive refinements, idiosyncrasies and unexpected