Zobrazeno 1 - 10
of 95
pro vyhledávání: '"Alan H. Stephenson"'
Autor:
Daniel eGoldman, Graham M. Fraser, Christopher G Ellis, Randy S. Sprague, Mary L. Ellsworth, Alan H. Stephenson
Publikováno v:
Frontiers in Physiology, Vol 3 (2012)
Integration of the numerous mechanisms that have been suggested to contribute to optimization of O2 supply to meet O2 need in skeletal muscle requires a systems biology approach which permits quantification of these physiological processes over a wid
Externí odkaz:
https://doaj.org/article/2f5ddb72e9614390a4584464ad88505b
Publikováno v:
Prostaglandins & Other Lipid Mediators. :131-135
Inappropriate platelet aggregation can result in thrombosis and tissue ischemia. When compared to healthy human platelets, those of humans with type 2 diabetes (DM2) exhibit increased aggregation when stimulated. Activation of the platelet prostacycl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3cee8e9842bb926b907d42eb4faea01a
https://doi.org/10.1016/j.prostaglandins.2014.12.002
https://doi.org/10.1016/j.prostaglandins.2014.12.002
Autor:
Jennifer P. Richards, Grant R. Kolar, Mary L. Ellsworth, Randy S. Sprague, Cory W. Jones, Gina L. C. Yosten, Alan H. Stephenson
Publikováno v:
American Journal of Physiology-Regulatory, Integrative and Comparative Physiology. 307:R862-R868
ATP release from erythrocytes in response to reduced oxygen (O2) tension stimulates local vasodilation, enabling these cells to direct perfusion to areas in skeletal muscle in need of O2. Erythrocytes of humans with type 2 diabetes do not release ATP
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0ad8788b2d7e37c78dbe2f1e6e1f4c40
https://doi.org/10.1152/ajpregu.00206.2014
https://doi.org/10.1152/ajpregu.00206.2014
Autor:
Stephanie M Knebel, Alan H. Stephenson, Amber K Zdanovec, Mary L. Ellsworth, Elizabeth A. Bowles, Randy S. Sprague, Mollisa M. Elrick
Publikováno v:
Experimental Biology and Medicine. 238:1069-1074
Prostacyclin (PGI2) and phosphodiesterase 5 (PDE5) inhibitors are potent vasodilators that are used alone and in combination for the treatment of pulmonary arterial hypertension (PAH). Although these vasodilators are known to stimulate relaxation of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::81a2578b5ea1ee1eff5a54385ec61b78
https://doi.org/10.1177/1535370213498981
https://doi.org/10.1177/1535370213498981
Publikováno v:
American Journal of Physiology-Heart and Circulatory Physiology. 304:H660-H666
Statin drugs inhibit 3-hydroxy-3-methylglutaryl CoA reductase, which reduces the synthesis of both cholesterol and isoprenoids (geranylgeranyl pyrophosphate and farnesyl pyrophosphate), with the latter being lipid molecules responsible for the posttr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e0aab7bb6ac0e20f8d79a50c68876316
https://doi.org/10.1152/ajpheart.00635.2012
https://doi.org/10.1152/ajpheart.00635.2012
Autor:
David A. Ford, Carolyn J. Albert, John A. Bowden, Alan H. Stephenson, Robert J. Brown, Fei Shao, Jesse D Procknow, John W. Lally
Publikováno v:
Lipids. 46:1169-1179
Cholesteryl esters (CE) are important lipid storage molecules. The present study demonstrates that sodiated adducts of CE molecular species form positive ions that can be detected in both survey scan mode as well as by exploiting class-specific fragm
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::be6c648b4d779c8ea8d0aff0239351de
https://doi.org/10.1007/s11745-011-3609-2
https://doi.org/10.1007/s11745-011-3609-2
Autor:
Alan H. Stephenson, Meera Sridharan, Shaquria P. Adderley, Elizabeth A. Bowles, Mary L. Ellsworth, Randy S. Sprague
Publikováno v:
Microcirculation. 18:128-135
Please cite this paper as: Adderley, Sridharan, Bowles, Stephenson, Sprague and Ellsworth (2011). Inhibition of ATP Release from Erythrocytes: A Role for EPACs and PKC. Microcirculation18(2), 128–135. Abstract Objective: Here we demonstrate that, i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bc06494f07e216aa57022d685462b070
https://doi.org/10.1111/j.1549-8719.2010.00073.x
https://doi.org/10.1111/j.1549-8719.2010.00073.x
Autor:
Kelly M. Thuet, Randy S. Sprague, Mary L. Ellsworth, Shaquria P. Adderley, Elizabeth A. Bowles, Meera Sridharan, Alan H. Stephenson
Publikováno v:
Medical Science Monitor : International Medical Journal of Experimental and Clinical Research
Summary Background Within erythrocytes (RBCs), cAMP levels are regulated by phosphodiesterases (PDEs). Increases in cAMP and ATP release associated with activation of β-adrenergic receptors (βARs) and prostacyclin receptors (IPRs) are regulated by
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0aeb8edcb91f3c39ac04faa0439e8b35
https://doi.org/10.12659/msm.881763
https://doi.org/10.12659/msm.881763
Autor:
David Achilleus, Alan H. Stephenson, Randy S. Sprague, Mary L. Ellsworth, Daniel Goldman, Christopher G. Ellis, Elizabeth A. Bowles
Publikováno v:
American Journal of Physiology-Heart and Circulatory Physiology. 299:H566-H573
Erythrocytes release both O2and a vasodilator, ATP, when exposed to reduced O2tension. We investigated the hypothesis that ATP release is impaired in erythrocytes of humans with type 2 diabetes (DM2) and that this defect compromises the ability of th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0a6d5e6d91f5e1a4042fee4ab54d44e7
https://doi.org/10.1152/ajpheart.00430.2010
https://doi.org/10.1152/ajpheart.00430.2010
Publikováno v:
Pharmacological Reports. 62:475-482
The erythrocyte, a cell responsible for carrying and delivering oxygen in the body, has often been regarded as simply a vehicle for the circulation of hemoglobin. However, it has become evident that this cell also participates in the regulation of va
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::94418584c08b153f553425e1544a8deb
https://doi.org/10.1016/s1734-1140(10)70303-0
https://doi.org/10.1016/s1734-1140(10)70303-0