Zobrazeno 1 - 10
of 63
pro vyhledávání: '"Alan H. Sharp"'
Autor:
Mark W. Becher, Joyce A. Kotzuk, Alan H. Sharp, Stephen W. Davies, Gillian P. Bates, Donald L. Price, Christopher A. Ross
Publikováno v:
Neurobiology of Disease, Vol 4, Iss 6, Pp 387-397 (1998)
Huntington's disease (HD) is caused by CAG triplet repeat expansion inIT15which leads to polyglutamine stretches in the HD protein product, huntingtin. The pathological hallmark of HD is the degeneration of subsets of neurons, primarily those in the
Externí odkaz:
https://doaj.org/article/752dd6562367466680a45503efc413c8
Autor:
Farhat A. Khan, Russell L. Margolis, Scott L. Loev, Alan H. Sharp, Shi-Hua Li, Christopher A. Ross
Publikováno v:
Neurobiology of Disease, Vol 3, Iss 2, Pp 121-128 (1996)
Dentatorubral and pallidoluylsian atrophy (DRPLA) is a progressive neurological disorder characterized by neuronal degeneration, especially in the cerebellar dentate nucleus. DRPLA is caused by an unstable expansion of a CAG trinucleotide repeat codi
Externí odkaz:
https://doaj.org/article/00ee289eb5fa4d7cb5eb07bc5129bfcf
Autor:
Alan H. Sharp, Christopher A. Ross
Publikováno v:
Neurobiology of Disease, Vol 3, Iss 1, Pp 3-15 (1996)
Externí odkaz:
https://doaj.org/article/0f7791ecbc314c9eaa36268ad25c9457
Autor:
James T. Russell, G. David Lange, Frederick C. Nucifora, Carol A. Sheppard, Peter B. Simpson, Alan H. Sharp, Christopher A. Ross
Publikováno v:
Journal of Neurochemistry. 68:2317-2327
We have examined the mechanisms that underlie Ca2+ wave propagation in cultured cortical astrocytes. Norepinephrine evoked Ca2+ waves in astrocytes that began at discrete initiation loci and propagated throughout the cell by regenerative amplificatio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5fb23340846674db8ecd6752895aef74
https://doi.org/10.1046/j.1471-4159.1997.68062317.x
https://doi.org/10.1046/j.1471-4159.1997.68062317.x
Autor:
Christopher A. Ross, J. Timothy Greenamyre, Solomon H. Snyder, Joseph F. Lawler, Alan H. Sharp, Gordon W. Wiegand, Jillian K. Cooper, Akira Sawa, Russell L. Margolis
Publikováno v:
Nature Medicine. 5:1194-1198
Huntington disease (HD) is a genetically dominant condition caused by expanded CAG repeats coding for glutamine in the HD gene product huntingtin1. Although HD symptoms reflect preferential neuronal death in specific brain regions, huntingtin is expr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::331e3b2c65fe6817b1b64bece8f98c0f
https://doi.org/10.1038/13518
https://doi.org/10.1038/13518
Autor:
Christopher A. Ross, Zachary Kaminsky, Ted M. Dawson, John J. Kleiderlein, Paul F. Worley, Valina L. Dawson, Alan H. Sharp, Simone Engelender, Anthony Lanahan, Xin Guo, Juan C. Troncoso, Russell L. Margolis, Ravi K. Amaravi
Publikováno v:
Nature Genetics. 22:110-114
Parkinson disease (PD) is a neurodegenerative disease characterized by tremor, bradykinesia, rigidity and postural instability. Post-mortem examination shows loss of neurons and Lewy bodies, which are cytoplasmic eosinophilic inclusions, in the subst
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8a413446836e7cfe133d39e9b52f16e3
https://doi.org/10.1038/8820
https://doi.org/10.1038/8820
Autor:
Solomon H. Snyder, James T. Russell, Olivier Blondel, Alan H. Sharp, Carol A. Sheppard, Frederick C. Nucifora, Chuanyi Zhang, Christopher A. Ross, David K. Ryugo
Publikováno v:
The Journal of Comparative Neurology. 406:207-220
Inositol 1,4,5-trisphosphate receptors (IP3R) are mediators of second messenger-induced intracellular calcium release. Three isoforms are known to be expressed in brain, but their regional distributions and cellular localizations are little known. In
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ff25ae462674b34d69bcc311986fea6c
https://doi.org/10.1002/(sici)1096-9861(19990405)406:2<207::aid-cne6>3.0.co
https://doi.org/10.1002/(sici)1096-9861(19990405)406:2<207::aid-cne6>3.0.co
Autor:
David R. Borchelt, Donald L. Price, Tamara Ratovitski, Christopher A. Ross, Joyce A. Kotzuk, K. Duan, Neal G. Copeland, Hilda H. Slunt, Alan H. Sharp, Nancy A. Jenkins, Mark W. Becher, Hyder A. Jinnah, Jillian K. Cooper, Gabriele Schilling
Publikováno v:
Human Molecular Genetics. 8:397-407
Huntington's disease (HD) is an inherited, neurodegenerative disorder caused by the expansion of a glutamine repeat in the N-terminus of the huntingtin protein. To gain insight into the pathogenesis of HD, we generated transgenic mice that express a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::93217a8f9e2f5d6f3bda20b15b9662ae
https://doi.org/10.1093/hmg/8.3.397
https://doi.org/10.1093/hmg/8.3.397
Autor:
Joyce A. Kotzuk, Christopher A. Ross, Donald L. Price, Alan H. Sharp, Mark W. Becher, Stephen W. Davies, Gillian P. Bates
Publikováno v:
Neurobiology of Disease, Vol 4, Iss 6, Pp 387-397 (1998)
Huntington's disease (HD) is caused by CAG triplet repeat expansion inIT15which leads to polyglutamine stretches in the HD protein product, huntingtin. The pathological hallmark of HD is the degeneration of subsets of neurons, primarily those in the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::95b224ca3a03c44b7397b07abb2d8209
http://www.sciencedirect.com/science/article/pii/S0969996198901681
http://www.sciencedirect.com/science/article/pii/S0969996198901681
Autor:
Simone Engelender, Christopher A. Ross, Anthony Lanahan, Paul F. Worley, Mariko Tokito, Alan H. Sharp, Veronica Colomer, Erika L.F. Holzbaur
Publikováno v:
Human Molecular Genetics. 6:2205-2212
Huntington's disease (HD) is an inherited neurodegenerative disease caused by expansion of a polyglutamine repeat in the HD protein huntingtin. Huntingtin's localization within the cell includes an association with cytoskeletal elements and vesicles.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2e8f96cc7bdd9570c96bc7bc40956755
https://doi.org/10.1093/hmg/6.13.2205
https://doi.org/10.1093/hmg/6.13.2205