Zobrazeno 1 - 10
of 28
pro vyhledávání: '"Alan H. Ganong"'
Autor:
Mary Piotrowski, Allen J. Duplantier, Christine A. Strick, Brian D. Harvey, Mark J. Majchrzak, Cheryl Li, Patricia A. Seymour, Christopher J. Schmidt, Carol B. Fox, Alan H. Ganong, Larry C. James, F. David Tingley, Andres D. Ramirez, James T. Downs, Mihály Hajós, Victor Guanowsky, Liam Scott, Stacey L. Becker, Youfen Xu, Stefanus J. Steyn, Ayman El-Kattan, Brian Rago
Publikováno v:
Neuropharmacology. 61:1001-1015
Observations that N-Methyl-D-Aspartate (NMDA) antagonists produce symptoms in humans that are similar to those seen in schizophrenia have led to the current hypothesis that schizophrenia might result from NMDA receptor hypofunction. Inhibition of D-a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::29d50eb849564a55d05e9986564219f8
https://doi.org/10.1016/j.neuropharm.2011.06.029
https://doi.org/10.1016/j.neuropharm.2011.06.029
Autor:
Angela C. Doran, John T. Lazzaro, Ivan Viktorovich Efremov, Allen J. Duplantier, Kenneth G. Kraus, Sheryl A. McCarthy, Douglas K. Spracklin, Lei Zhang, Jiemin Lu, Theresa J. O’Sullivan, Judith A. Siuciak, Ashley N. Hanks, Alan H. Ganong, Bruce N. Rogers, Jessica A. Haas, John Candler, Noha Maklad
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 19:2524-2529
The discovery, synthesis and SAR of a novel series of 3-benzyl-1,3-oxazolidin-2-ones as positive allosteric modulators (PAMs) of mGluR2 is described. Expedient hit-to-lead work on a single HTS hit led to the identification of a ligand-efficient and s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2ae2f0792ed614fca82f8250d78a7836
https://doi.org/10.1016/j.bmcl.2009.03.032
https://doi.org/10.1016/j.bmcl.2009.03.032
Autor:
Alan H. Ganong, Juan Lerma, Bertrand L. Chenard, Frank S. Menniti, Ana V. Paternain, J. Huang, Frank E. Ewing, Willard M. Welch, John T. Lazzaro
Publikováno v:
Digital.CSIC. Repositorio Institucional del CSIC
instname
instname
11 páginas, 7 figuras.
The hypothesis that aberrant α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor activity contributes to epileptogenesis and neurodegeneration has prompted the search for AMPA receptor antagonists as pot
The hypothesis that aberrant α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor activity contributes to epileptogenesis and neurodegeneration has prompted the search for AMPA receptor antagonists as pot
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c7520c53e9c47ebc9aee67ba3bd4dd37
https://doi.org/10.1016/s0028-3908(01)00170-8
https://doi.org/10.1016/s0028-3908(01)00170-8
Autor:
Alan H. Ganong, Melinda D. Rottas, Jessica A. Haas, Sheryl A. McCarthy, Christopher J. Schmidt, Kenneth G. Kraus, Angela C. Doran, Edel Evrard, John Candler, Lei Zhang, Ashley N. Hanks, Allen J. Duplantier, Andy Q. Zhang, Noha Maklad, John T. Lazzaro, Weimin Qian, Ivan Viktorovich Efremov, Keith Jenza, Bruce N. Rogers, Michael Aaron Brodney, Judith A. Siuciak, F. David Tingley
Publikováno v:
Journal of medicinal chemistry. 54(6)
A novel series of mGluR2 positive allosteric modulators (PAMs), 1-[(1-methyl-1H-imidazol-2-yl)methyl]-4-phenylpiperidines, is herein disclosed. Structure-activity relationship studies led to potent, selective mGluR2 PAMs with excellent pharmacokineti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3e35f941c0527c9d6f18ef786569e5f3
https://pubmed.ncbi.nlm.nih.gov/21366332
https://pubmed.ncbi.nlm.nih.gov/21366332
Autor:
James Heym, James P. Rizzi, Karen J. Guarino, J. L. Ives, Terry J. Rosen, Jolanta Nowakowski, June Daffeh, Arthur Adam Nagel, Seeger Thomas Francis, Alan H. Ganong, Anne W. Schmidt, Chester J. Siok, Stafford McLean, Lawrence A. Vincent
Publikováno v:
ChemInform. 22
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a7872c01fd2095f9a8852ba4938bc0a6
https://doi.org/10.1002/chin.199110163
https://doi.org/10.1002/chin.199110163
Publikováno v:
Synapse. 9:244-250
The effects of arylamine spider toxins on synaptic transmission in rat hippocampal slices were investigated. Two different responses were monitored: the AMPA receptor-mediated population spike recorded in control buffer (selectively antagonized by DN
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7cba3d5c12968e8632ba5b86a31ecb31
https://doi.org/10.1002/syn.890090403
https://doi.org/10.1002/syn.890090403
Autor:
Bruce N. Rogers, Lei Zhang, Weimin Qian, Alan H. Ganong, John Candler, Allen J. Duplantier, Angela C. Doran, Helen Berke, Andy Q. Zhang, Stanley F. McHardy, John T. Lazzaro, Ivan Viktorovich Efremov, Noha Maklad
Publikováno v:
Bioorganicmedicinal chemistry letters. 18(20)
The synthesis and structure–activity relationship (SAR) of a novel series of 3-(imidazolyl methyl)-3-aza-bicyclo[3.1.0]hexan-6-yl)methyl ethers, derived from a high throughput screening (HTS), are described. Subsequent optimization led to identific
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c1c2926e12cc5a6c438c63b040f7e927
https://pubmed.ncbi.nlm.nih.gov/18812259
https://pubmed.ncbi.nlm.nih.gov/18812259
Autor:
Devries Keith Michael, Patricia A. Seymour, T.L Staigers, Frank S. Menniti, Kristin Kelly, S Guhan, D Critchett, Alan H. Ganong, M.R Guinn, John T. Lazzaro, Victor Guanowsky, Willard M. Welch, Martin J. Pagnozzi, J. Huang, Frank E. Ewing, Bertrand L. Chenard
Publikováno v:
Bioorganicmedicinal chemistry letters. 11(2)
Piriqualone (1) was found to be an antagonist of AMPA receptors. Structure activity optimization was conducted on each of the three rings in 1 to afford a series of potent and selective antagonists. The sterically crowded environment surrounding the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::07b49de76e880422fa3414c1603f68ac
https://pubmed.ncbi.nlm.nih.gov/11206453
https://pubmed.ncbi.nlm.nih.gov/11206453
Autor:
Linda Reynolds, John A. Lowe, Alan H. Ganong, Kara G. Pratt, Seeger Thomas Francis, James Heym, Stafford McLean, Dianne K. Bryce, Chester J. Siok
Publikováno v:
Science. 251:437-439
CP-96,345, a nonpeptide substance P antagonist, is selective for the tachykinin NK1 receptor. The compound binds to a single population of sites in guinea pig brain and potently inhibits substance P-induced excitation of locus ceruleus neurons. CP-96
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7d7b5638657fc9714321e1818598314a
https://doi.org/10.1126/science.1703324
https://doi.org/10.1126/science.1703324
Autor:
Robert D. Williams, Robert A. Volkmann, Thomas N. Parks, Kelly Mary E, Nicholas A. Saccomano, Chester J. Siok, Steven D. Heck, William R. Gray, Peter F. Thadeio, Karen J. Krapcho, Hunter Jackson, Michael K. Ahlijanian, Alan H. Ganong, Melissa J. Welch, Paul R. Kelbaugh, Anthony J. Lanzetti, Phillips Douglas
Publikováno v:
Science (New York, N.Y.). 266(5187)
The venom of the funnel-web spider Agelenopsis aperta contains several peptides that paralyze prey by blocking voltage-sensitive calcium channels. Two peptides, omega-Aga-IVB (IVB) and omega-Aga-IVC (IVC), have identical amino acid sequences, yet hav
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::06b741be6854425a53a7d12c897ab8d2
https://pubmed.ncbi.nlm.nih.gov/7973683
https://pubmed.ncbi.nlm.nih.gov/7973683