Zobrazeno 1 - 10
of 29
pro vyhledávání: '"Alan G.S. Harper"'
Publikováno v:
Platelets, Vol 34, Iss 1 (2023)
Thrombus formation is highly dependent upon the physico-chemical environment in which it is triggered. Our ability to understand how thrombus formation is initiated, regulated, and resolved in the human body is dependent upon our ability to replicate
Externí odkaz:
https://doaj.org/article/c0c54cb0f9a946d293b7c90fd998cb4b
Publikováno v:
Platelets. 34
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5b2ed6d93df00fa17aae329a46d8b228
https://doi.org/10.1080/09537104.2022.2153823
https://doi.org/10.1080/09537104.2022.2153823
Publikováno v:
Journal of thrombosis and haemostasis : JTHREFERENCES. 20(11)
BACKGROUND: Thrombolysis is a frontline treatment for stroke, which involves the application of tissue plasminogen activator (tPA) to trigger endogenous clot-degradation pathways.However, it is only effective within 4.5 hours of symptom onset due to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::df088518ee9c01bd83055f009bef432f
https://pubmed.ncbi.nlm.nih.gov/35950914
https://pubmed.ncbi.nlm.nih.gov/35950914
Autor:
Faiza Idris Musa, Andrea C Hernández Hernández, Ying Yang, Alan G.S. Harper, Robert Butler, Wanjiku Njoroge
Publikováno v:
Pharmaceutics
Volume 13
Issue 3
Pharmaceutics, Vol 13, Iss 340, p 340 (2021)
Volume 13
Issue 3
Pharmaceutics, Vol 13, Iss 340, p 340 (2021)
Cardiovascular disease is a major cause of death globally. This has led to significant efforts to develop new anti-thrombotic therapies or re-purpose existing drugs to treat cardiovascular diseases. Due to difficulties of obtaining healthy human bloo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7889ff223da7c5722a985f7d8cda08eb
https://eprints.keele.ac.uk/9380/1/pharmaceutics-13-00340-v2.pdf
https://eprints.keele.ac.uk/9380/1/pharmaceutics-13-00340-v2.pdf
Publikováno v:
Nano research
Human platelets aggregate at sites of blood vessel damage in response to a rise in their cytosolic calcium concentration. Controlling these cytosolic calcium rises would provide a method to inhibit platelet activation and prevent the unwanted blood c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::96210020c2daedacbeced7e038cd4d56
https://eprints.keele.ac.uk/8244/3/Cabrera2020_Article_ControllingHumanPlateletActiva.pdf
https://eprints.keele.ac.uk/8244/3/Cabrera2020_Article_ControllingHumanPlateletActiva.pdf
Publikováno v:
Diabetologia
Cystic fibrosis-related diabetes (CFRD) is the most significant extra-pulmonary comorbidity in cystic fibrosis (CF) patients, and accelerates lung decline. In addition to the traditional view that CFRD is a consequence of fibrotic destruction of the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f069fa27b790da64e27a6ff490d0f0c5
http://europepmc.org/articles/PMC4901107
http://europepmc.org/articles/PMC4901107
Autor:
Peterson Anand, Alan G.S. Harper
Publikováno v:
Cell Calcium. 90:102248
Human platelets use a rise in cytosolic Ca2+ concentration to activate all stages of thrombus formation, however, how they are able to decode cytosolic Ca2+ signals to trigger each of these independently is unknown. Other cells create local Ca2+ sign
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e5609880bf2a062af4d192e7003163ed
https://doi.org/10.1016/j.ceca.2020.102248
https://doi.org/10.1016/j.ceca.2020.102248
Publikováno v:
British Journal of Pharmacology. 173:234-247
Background and purpose Recently, we demonstrated that a pericellular Ca(2+) recycling system potentiates agonist-evoked Ca(2+) signalling and granule secretion in human platelets and hypothesized a role for the membrane complex (MC) in orchestrating
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::02eb4b9beffc4dd5fd2aeedcdc0fe49e
https://doi.org/10.1111/bph.13361
https://doi.org/10.1111/bph.13361
Publikováno v:
Future Science OA
Coronary artery disease is a growing concern. Although traditional biomarkers, such as troponins and creatine kinase, play a central role in the diagnosis, risk stratification and management of coronary artery disease, they are unable to detect myoca
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2f2dde08acabef59a5179675c3a1c9e0
http://europepmc.org/articles/PMC5729601
http://europepmc.org/articles/PMC5729601
Autor:
Alan G.S. Harper, S O Sage
Publikováno v:
Platelets in Thrombotic and Non-Thrombotic Disorders ISBN: 9783319474601
A rise in cytosolic calcium concentration ([Ca2+]cyt) is central to platelet activation. Agonists stimulate a rise in [Ca2+]cyt through a combination of Ca2+ release from intracellular stores located in the dense tubular system (DTS) and acidic organ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6b26403eb25cfc4b94d0c2c5b8771797
https://doi.org/10.1007/978-3-319-47462-5_21
https://doi.org/10.1007/978-3-319-47462-5_21