Zobrazeno 1 - 10
of 23
pro vyhledávání: '"Alan G S, Harper"'
Publikováno v:
Biomimetics, Vol 9, Iss 6, p 372 (2024)
Acute cardiovascular events result from clots caused by the rupture and erosion of atherosclerotic plaques. This paper aimed to produce a functional biomimetic hydrogel of the neointimal layer of the atherosclerotic plaque that can support thrombogen
Externí odkaz:
https://doaj.org/article/a808903488c3438c8b4d89ddcdaf2cd6
Autor:
Jacob Ranjbar, Wanjiku Njoroge, Jonathan M. Gibbins, Paul Roach, Ying Yang, Alan G. S. Harper
Publikováno v:
Gels, Vol 9, Iss 6, p 477 (2023)
Current in vitro thrombosis models utilise simplistic 2D surfaces coated with purified components of the subendothelial matrix. The lack of a realistic humanised model has led to greater study of thrombus formation in in vivo tests in animals. Here w
Externí odkaz:
https://doaj.org/article/c0ae940eef0c494291826dc3e8a3c484
Autor:
Wanjiku Njoroge, Andrea C. Hernández Hernández, Faiza Idris Musa, Robert Butler, Alan G. S. Harper, Ying Yang
Publikováno v:
Pharmaceutics, Vol 13, Iss 3, p 340 (2021)
Cardiovascular disease is a major cause of death globally. This has led to significant efforts to develop new anti-thrombotic therapies or re-purpose existing drugs to treat cardiovascular diseases. Due to difficulties of obtaining healthy human bloo
Externí odkaz:
https://doaj.org/article/0e5fbc8bfb6d45a9bd799229310fe911
Publikováno v:
Platelets. 34(1)
Thrombus formation is highly dependent upon the physico-chemical environment in which it is triggered. Our ability to understand how thrombus formation is initiated, regulated, and resolved in the human body is dependent upon our ability to replicate
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::be79804d4f41b290404b67171494b5c0
https://pubmed.ncbi.nlm.nih.gov/36550074
https://pubmed.ncbi.nlm.nih.gov/36550074
Autor:
Peterson, Anand, Alan G S, Harper
Publikováno v:
Cell calcium. 90
Human platelets use a rise in cytosolic Ca
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::98e2bb3706b89be560e27253749b56ae
https://pubmed.ncbi.nlm.nih.gov/32629299
https://pubmed.ncbi.nlm.nih.gov/32629299
Autor:
Alan G S, Harper, Stewart O, Sage
Publikováno v:
Advances in experimental medicine and biology. 898
Na(+)/Ca(2+) exchangers (NCXs) have traditionally been viewed principally as a means of Ca(2+) removal from non-excitable cells. However there has recently been increasing interest in the operation of NCXs in reverse mode acting as a means of eliciti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::d10276f30ea002efcfb714cf7b6b9633
https://pubmed.ncbi.nlm.nih.gov/27161225
https://pubmed.ncbi.nlm.nih.gov/27161225
Publikováno v:
Cell calcium. 58(6)
Rises in cytosolic Ca(2+) concentration ([Ca(2+)]cyt) are central in platelet activation, yet many aspects of the underlying mechanisms are poorly understood. Most studies examine how experimental manipulations affect agonist-evoked rises in [Ca(2+)]
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::0a083292d9fb9bbcae7b86849ee08970
https://pubmed.ncbi.nlm.nih.gov/26434503
https://pubmed.ncbi.nlm.nih.gov/26434503
Autor:
Pedro C, Redondo, Alan G S, Harper, Ginés M, Salido, Jose A, Pariente, Stewart O, Sage, Juan A, Rosado
Publikováno v:
The Journal of physiology. 558(Pt 1)
Store-mediated Ca2+ entry (SMCE) is a major mechanism for Ca2+ influx in non-excitable cells. Recently, a conformational coupling mechanism allowing coupling between transient receptor potential channels (TRPCs) and IP3 receptors has been proposed to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::b1b31e5d02317dd80d655334b11976db
https://pubmed.ncbi.nlm.nih.gov/15121806
https://pubmed.ncbi.nlm.nih.gov/15121806
Autor:
Echrish, Jassim1 (AUTHOR), Pasca, Madalina-Ioana1 (AUTHOR), Cabrera, David2 (AUTHOR) d.c.cabrera@keele.ac.uk, Yang, Ying2 (AUTHOR) y.yang@keele.ac.uk, Harper, Alan G. S.1 (AUTHOR) a.g.s.harper@keele.ac.uk
Publikováno v:
Biomimetics (2313-7673). Jun2024, Vol. 9 Issue 6, p372. 24p.
Developing human tissue engineered arterial constructs to simulate human in vivo thrombus formation.
Publikováno v:
Platelets. Dec2023, Vol. 34 Issue 1, p1-7. 7p.