Zobrazeno 1 - 10
of 127
pro vyhledávání: '"Alan G, Ramsay"'
Autor:
Graham McIlroy, Siân Lax, Charlotte Gaskell, Aimee Jackson, Malcolm Rhodes, Tania Seale, Sonia Fox, Lousie Hopkins, Jessica Okosun, Sally F. Barrington, Ingo Ringshausen, Alan G. Ramsay, Maria Calaminici, Kim Linton, Mark Bishton
Publikováno v:
BMC Cancer, Vol 24, Iss 1, Pp 1-13 (2024)
Abstract Background Relapsed or refractory follicular lymphoma (rrFL) is an incurable disease associated with shorter remissions and survival after each line of standard therapy. Many promising novel, chemotherapy-free therapies are in development, b
Externí odkaz:
https://doaj.org/article/569fb28841214450b4923be543937b12
Autor:
Benedetta Apollonio, Filomena Spada, Nedyalko Petrov, Domenico Cozzetto, Despoina Papazoglou, Peter Jarvis, Shichina Kannambath, Manuela Terranova-Barberio, Rose-Marie Amini, Gunilla Enblad, Charlotte Graham, Reuben Benjamin, Elisabeth Phillips, Richard Ellis, Rosamond Nuamah, Mansoor Saqi, Dinis P. Calado, Richard Rosenquist, Lesley A. Sutton, Jon Salisbury, Georgios Zacharioudakis, Anna Vardi, Patrick R. Hagner, Anita K. Gandhi, Marina Bacac, Christina Claus, Pablo Umana, Ruth F. Jarrett, Christian Klein, Alexander Deutsch, Alan G. Ramsay
Publikováno v:
The Journal of Clinical Investigation, Vol 133, Iss 13 (2023)
Recent transcriptomic-based analysis of diffuse large B cell lymphoma (DLBCL) has highlighted the clinical relevance of LN fibroblast and tumor-infiltrating lymphocyte (TIL) signatures within the tumor microenvironment (TME). However, the immunomodul
Externí odkaz:
https://doaj.org/article/64362547860a4260b7c3b6b1f73eefcb
Autor:
Giulia Pagano, Iria Fernandez Botana, Marina Wierz, Philipp M. Roessner, Nikolaos Ioannou, Xiangda Zhou, Gheed Al-Hity, Coralie Borne, Ernesto Gargiulo, Susanne Gonder, Bin Qu, Basile Stamatopoulos, Alan G. Ramsay, Martina Seiffert, Anne Largeot, Etienne Moussay, Jerome Paggetti
Publikováno v:
Haematologica, Vol 108, Iss 11 (2023)
Chronic lymphocytic leukemia (CLL) cells are highly dependent on interactions with the immunosuppressive tumor microenvironment (TME) for survival and proliferation. In the search for novel treatments, pro-inflammatory cytokines have emerged as candi
Externí odkaz:
https://doaj.org/article/f29683a86d924b2e8fdf058bdcf1c6eb
Autor:
Francesca Arruga, Marta Rubin, Despoina Papazoglou, Andrea Iannello, Nikolaos Ioannou, Riccardo Moia, Davide Rossi, Gianluca Gaidano, Marta Coscia, Luca Laurenti, Giovanni D’Arena, John N. Allan, Richard R. Furman, Tiziana Vaisitti, Alan G. Ramsay, Silvia Deaglio
Publikováno v:
Haematologica, Vol 108, Iss 8 (2023)
T-cell immunoreceptor with Ig and ITIM domains (TIGIT) is an inhibitory checkpoint receptor that negatively regulates Tcell responses. CD226 competes with TIGIT for binding to the CD155 ligand, delivering a positive signal to the T cell. Here we stud
Externí odkaz:
https://doaj.org/article/1d0bf1e229914fc2a812f673e329ebdb
Publikováno v:
Haematologica, Vol 106, Iss 9 (2021)
The tumor microenvironment (TME) plays an essential role in the development, growth, and survival of the malignant B-cell clone in chronic lymphocytic leukemia (CLL). Within the proliferation niches of lymph nodes, bone marrow, and secondary lymphoid
Externí odkaz:
https://doaj.org/article/22184c056ff04676a97ca99c5c61753b
Autor:
James W Opzoomer, Jessica A Timms, Kevin Blighe, Thanos P Mourikis, Nicolas Chapuis, Richard Bekoe, Sedigeh Kareemaghay, Paola Nocerino, Benedetta Apollonio, Alan G Ramsay, Mahvash Tavassoli, Claire Harrison, Francesca Ciccarelli, Peter Parker, Michaela Fontenay, Paul R Barber, James N Arnold, Shahram Kordasti
Publikováno v:
eLife, Vol 10 (2021)
High-dimensional cytometry is an innovative tool for immune monitoring in health and disease, and it has provided novel insight into the underlying biology as well as biomarkers for a variety of diseases. However, the analysis of large multiparametri
Externí odkaz:
https://doaj.org/article/78033dd608be40de9a83b21d8e652c8c
Autor:
Piers E. M. Patten, Gerardo Ferrer, Shih-Shih Chen, Jonathan E. Kolitz, Kanti R. Rai, Steven L. Allen, Jacqueline C. Barrientos, Nikolaos Ioannou, Alan G. Ramsay, Nicholas Chiorazzi
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
Patient-derived xenograft models of chronic lymphocytic leukemia (CLL) can be created using highly immunodeficient animals, allowing analysis of primary tumor cells in an in vivo setting. However, unlike many other tumors, CLL B lymphocytes do not re
Externí odkaz:
https://doaj.org/article/8a7c17a8f2f34ec0bfe17f199c06f5ca
Publikováno v:
Frontiers in Oncology, Vol 11 (2021)
Cancers, including lymphomas, develop in complex tissue environments where malignant cells actively promote the creation of a pro-tumoral niche that suppresses effective anti-tumor effector T cell responses. Research is revealing that the tumor micro
Externí odkaz:
https://doaj.org/article/f01284a17ec34cf890dbf2212a6df753
Autor:
Ernesto Gargiulo, Elodie Viry, Pablo Elías Morande, Anne Largeot, Susanne Gonder, Feng Xian, Nikolaos Ioannou, Mohaned Benzarti, Felix Bruno Kleine Borgmann, Michel Mittelbronn, Gunnar Dittmar, Petr V. Nazarov, Johannes Meiser, Basile Stamatopoulos, Alan G. Ramsay, Etienne Moussay, Jérôme Paggetti
Publikováno v:
Gargiulo, E, Viry, E, Morande, P E, Largeot, A, Gonder, S, Xian, F, Ioannou, N, Benzarti, M, Kleine Borgmann, F B, Mittelbronn, M, Dittmar, G, Nazarov, P V, Meiser, J, Stamatopoulos, B, Ramsay, A G, Moussay, E & Paggetti, J 2022, ' Extracellular vesicle secretion by leukemia cells in vivo promotes CLL progression by hampering antitumor T-cell responses ', Blood Cancer Discovery . https://doi.org/10.1158/2643-3230.BCD-22-0029
Small extracellular vesicle (sEV, or exosome) communication among cells in the tumor microenvironment has been modeled mainly in cell culture, whereas their relevance in cancer pathogenesis and progression in vivo is less characterized. Here we inves
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9c513b86d2bfe26fff2b68d31c242ccd
https://doi.org/10.1158/2643-3230.bcd-22-0029
https://doi.org/10.1158/2643-3230.bcd-22-0029
Autor:
Jérôme Paggetti, Etienne Moussay, Alan G. Ramsay, Basile Stamatopoulos, Johannes Meiser, Petr V. Nazarov, Gunnar Dittmar, Michel Mittelbronn, Felix Bruno Kleine Borgmann, Mohaned Benzarti, Nikolaos Ioannou, Feng Xian, Susanne Gonder, Anne Largeot, Pablo Elías Morande, Elodie Viry, Ernesto Gargiulo
Supplemental Table S3 - Patient clinical information
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::11bde897ae1aaa91c1ad0c22f68bc568
https://doi.org/10.1158/2643-3230.22546050.v1
https://doi.org/10.1158/2643-3230.22546050.v1
