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of 198
pro vyhledávání: '"Alan Frazer"'
Autor:
Stephanie M. Perez, Alexandra M. McCoy, Thomas D. Prevot, Md Yeunus Mian, Flavia R. Carreno, Alan Frazer, James M. Cook, Etienne Sibille, Daniel J. Lodge
Publikováno v:
Biological Psychiatry Global Open Science, Vol 3, Iss 1, Pp 78-86 (2023)
Background: Aberrant dopamine neuron activity is attributable to hyperactivity in hippocampal subfields driving a pathological increase in dopamine neuron activity, which is positively correlated with psychosis in humans. Evidence indicates that hipp
Externí odkaz:
https://doaj.org/article/084ff4c6137d42009c20604b31e46173
Autor:
Ameet S. Nagpal, Daniel J. Lodge, Jennifer S. Potter, Alan Frazer, Robin Tragus, Megan E. Curtis, Angela M. Boley, Maxim Eckmann
Publikováno v:
Frontiers in Pain Research, Vol 3 (2022)
Background and ObjectivesPatients taking opioids are at risk of developing dependence and possibly abuse. Given the role of the mesolimbic dopamine system in opioid reward, blocking dopamine D2 receptors should limit the abuse liability of opioid ana
Externí odkaz:
https://doaj.org/article/3debbd027fb049a0a307577c43d0e983
Publikováno v:
PLoS ONE, Vol 7, Iss 5, p e34844 (2012)
Vagal nerve stimulation (VNS) has been approved for treatment-resistant depression. Many antidepressants increase expression of brain-derived neurotrophic factor (BDNF) in brain or activate, via phosphorylation, its receptor, TrkB. There have been no
Externí odkaz:
https://doaj.org/article/f50463dc07194c4ab2b94b21da6ab292
Norepinephrine is a chemical neurotransmitter. Drugs that directly manipulate central nervous system (CNS) norepinephrine are being developed targeting noradrenergic neurons to deliver therapeutic effects. Noradrenergic drugs have been proven effecti
Autor:
Alexandra M McCoy, Thomas D Prevot, Md Yenus Mian, James M Cook, Alan Frazer, Etienne L Sibille, Flavia R Carreno, Daniel J Lodge
Publikováno v:
The international journal of neuropsychopharmacology. 25(8)
Background Up to 64% of patients diagnosed with posttraumatic stress disorder (PTSD) experience psychosis, likely attributable to aberrant dopamine neuron activity. We have previously demonstrated that positive allosteric modulators of α5-GABAARs ca
Autor:
Alan Frazer, Vladislav Bugay, Robert Brenner, Flavia Regina Carreno, Alexandra Maxine McCoy, Daniel J. Lodge
Publikováno v:
Neuropsychopharmacology
Previous research has demonstrated that selective modulation of hippocampal transmission by systemic administration of an α5-GABA(A) receptor negative allosteric modulator, L-655,708, reproduces the sustained antidepressant-like (AD-like) effect of
Autor:
Alan Frazer, Charles B. Nemeroff
Publikováno v:
Neuropsychopharmacology
Publikováno v:
International Journal of Neuropsychopharmacology
Background: Selective augmentation of hippocampal activity in ways similar to that caused by ketamine may have therapeutic advantages over ketamine, which has psychotomimetic and reinforcing effects likely due to effects outside the hippocampus (i.e.
Publikováno v:
Behav Brain Res
Numerous randomized double-blind clinical trials have consistently shown that that a single intravenous administration of a subanesthetic dose of ketamine to treatment-resistant depressed patients significantly improved depressive symptomatology rapi