Zobrazeno 1 - 10
of 52
pro vyhledávání: '"Alan F. Zahorchak"'
Autor:
Silvia Liu, Alan F. Zahorchak, Steven F. Dobrowolski, Diana M. Metes, Angus W. Thomson, Hossam A. Abdelsamed
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-11 (2024)
Abstract During differentiation of precursor cells into their destination cell type, cell fate decisions are enforced by a broad array of epigenetic modifications, including DNA methylation, which is reflected by the transcriptome. Thus, regulatory d
Externí odkaz:
https://doaj.org/article/792445a8ea6e476e856df477eeebc201
Autor:
Kazuki Sasaki, Mouhamad Al Moussawy, Khodor I. Abou-Daya, Camila Macedo, Amira Hosni-Ahmed, Silvia Liu, Mariam Juya, Alan F. Zahorchak, Diana M. Metes, Angus W. Thomson, Fadi G. Lakkis, Hossam A. Abdelsamed
Publikováno v:
Communications Biology, Vol 5, Iss 1, Pp 1-15 (2022)
Human activated memory CD8 T cells develop a non-cytotoxic function and influence the fate of autologous naïve CD8 T cells where they acquire an activated/memory state and a hybrid state between naïve and activated memory.
Externí odkaz:
https://doaj.org/article/44b4b05e7ad3482c93e236ebb6b01b84
Autor:
Alan F. Zahorchak, Misty L. DeRiggi, Jennifer L. Muzzio, Veronica Sutherland, Abhinav Humar, Fadi G. Lakkis, Yen-Michael S. Hsu, Angus W. Thomson
Publikováno v:
Cytotherapy. 25:432-441
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::869701c333e6f806d2ad9b4bfc367d6c
https://doi.org/10.1016/j.jcyt.2022.11.005
https://doi.org/10.1016/j.jcyt.2022.11.005
Autor:
Helong Dai, Kazuki Sasaki, Lien Lu, Hong Zhang, Angelica Perez-Gutierrez, Alan F. Zahorchak, Mohamed Ezzelarab, Jay K. Bhama, Angus W. Thomson, Dirk J. van der Windt
Publikováno v:
Transplantation
BACKGROUND Regulatory T cell (Treg) therapy is a promising approach to amelioration of allograft rejection and promotion of organ transplant tolerance. However, the fate of infused Treg, and how this relates to their therapeutic efficacy using differ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5a60e9b7495a3f0fd9dcca91ed2c8b45
https://doi.org/10.1097/tp.0000000000003617
https://doi.org/10.1097/tp.0000000000003617
Autor:
Kazuki Saski, Mouhamad Al Moussawy, Khodor I. Abou-Daya, Camila. Macedo, Amira Hosni-Ahmed, Silvia Liu, Mariam Juya, Alan F. Zahorchak, Diana M. Metes, Angus W. Thomson, Fadi G. Lakkis, Hossam A. Abdelsamed
T cells are endowed with the capacity to sense their environment including other T cells around them. They do so to set their numbers and activation thresholds. This form of regulation has been well-studied within a given T cell population – i.e.,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::de40d661943f1e77330bb2411af83b6c
https://doi.org/10.21203/rs.3.rs-1651269/v1
https://doi.org/10.21203/rs.3.rs-1651269/v1
Autor:
ANGUS W THOMSON, ALAN F ZAHORCHAK, Mohamed B. Ezzelarab, Lisa H. Butterfield, Fadi G. Lakkis, Diana M Metes
Publikováno v:
Frontiers in Immunology, Vol 7 (2016)
Dendritic cells (DC) are rare, professional antigen-presenting cells with ability to induce or regulate alloimmune responses. Regulatory DC (DCreg) with potential to down-modulate acute and chronic inflammatory conditions that occur in organ transpla
Externí odkaz:
https://doaj.org/article/ced4eb14dfe649949fcc10769b019947
Autor:
Fadi G. Lakkis, Camila Macedo, Angus W. Thomson, Alan F. Zahorchak, Thalachallour Mohanakumar, Lillian M. Tran, Xinyan Gu, Ranjithkumar Ravichandran, Adriana Zeevi, Diana Metes, Beth Elinoff, Abhinav Humar, Mindi A. Styn, Helong Dai
Publikováno v:
American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons. 21(7)
Regulatory dendritic cells (DCreg) promote transplant tolerance following their adoptive transfer in experimental animals. We investigated the feasibility, safety, fate, and impact on host T cells of donor monocyte-derived DCreg infused into prospect
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::63114109dd71a0bf0972bfece2a1a7d4
https://pubmed.ncbi.nlm.nih.gov/33559167
https://pubmed.ncbi.nlm.nih.gov/33559167
Autor:
Angus W. Thomson, Lisa H. Butterfield, Camila Macedo, Alan F. Zahorchak, David E. Hamm, Diana Metes
Publikováno v:
Cellular Immunology. 323:9-18
Human regulatory dendritic cells (DCreg) were generated from CD14 immunobead-purified or elutriated monocytes in the presence of vitamin D3 and IL-10. They exhibited similar, low levels of costimulatory CD80 and CD86, but comparatively high levels of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::719088a816c0434970e4341a8646aba6
https://doi.org/10.1016/j.cellimm.2017.08.008
https://doi.org/10.1016/j.cellimm.2017.08.008
Autor:
Martin Wijkstrom, Marta I. Minervini, Roger W. Wiseman, Abhinav Humar, Yu-Chao Wang, Alan F. Zahorchak, Angelica Perez-Gutierrez, Lien Lu-Casto, Mohamed Ezzelarab, Angus W. Thomson
Publikováno v:
Transpl Immunol
Myeloid-derived suppressor cells (MDSC) are a heterogenous population of immunosuppressive myeloid cells now considered important immune regulatory cells in diverse clinical conditions, including cancer, chronic inflammatory disorders and transplanta
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::19d8d45dfcac8f4cbdd3764f263b8676
https://pubmed.ncbi.nlm.nih.gov/31330261
https://pubmed.ncbi.nlm.nih.gov/31330261
Autor:
Lien Lu, Alan F. Zahorchak, Angus W. Thomson, William F. Shufesky, H. Guo, David K. C. Cooper, Mohamed Ezzelarab, Adrian E. Morelli
Publikováno v:
Transplantation. 100:91-102
Memory T cells (Tmem), particularly those resistant to costimulation blockade (CB), are a major barrier to transplant tolerance. The transcription factor Eomesodermin (Eomes) is critical for Tmem development and maintenance, but its expression by all
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1db21051d3dd01d303a9a8c25bb77c04
https://doi.org/10.1097/tp.0000000000000871
https://doi.org/10.1097/tp.0000000000000871