Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Alan F. Moore"'
Publikováno v:
The American Journal of Cardiology. 81:40D-46D
Azimilide, a novel class III antiarrhythmic agent, blocks both the slowly activating (IKs) and rapidly activating (IKr) components of the delayed rectifier potassium current, which distinguishes it from conventional potassium channel blockers such as
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::00f13951129a9d904bc1fa5254b1baed
https://doi.org/10.1016/s0002-9149(98)00152-0
https://doi.org/10.1016/s0002-9149(98)00152-0
Publikováno v:
Physiology & Behavior. 28:885-891
Male adult spontaneously hypertensive rats (SHR) ate the same but drank more and had a higher water to food ratio (W:F) than did Wistar-Kyoto (WKY) rats in 24-hr when they had continuous access to standard laboratory pellets and tap water. When rats
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2fc68f59229267995af1a8eb39fce185
https://doi.org/10.1016/0031-9384(82)90209-8
https://doi.org/10.1016/0031-9384(82)90209-8
Autor:
Robert W. Fulton, Alan F. Moore
Publikováno v:
Drug Development Research. 4:331-349
Saralasin is the only marketed member of a class of compounds described as angiotensin II receptor antagonists. Its pharmacology is characterized by three general properties: (1) no actions unrelated to the renin-angiotensin system; (2) a small parti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::65fedef8c0fa8b84719ed9d8eec860a9
https://doi.org/10.1002/ddr.430040309
https://doi.org/10.1002/ddr.430040309
Publikováno v:
European Journal of Pharmacology. 39:101-107
On the rabbit isolated aorta, dose-dependent contractions to both angiotensin II and heptapeptide ([des-Asp1]-angiotensin II) were obtained. The curves were parallel, and reached the same maximum level. On the rat isolated uterus, angiotensin II and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::04a1b372fdeb26d17c14011ebd35bca8
https://doi.org/10.1016/0014-2999(76)90117-5
https://doi.org/10.1016/0014-2999(76)90117-5
Publikováno v:
Experimental Biology and Medicine. 176:452-459
Nolinium bromide inhibits gastric acid secretion and gastrointestinal smooth muscle contraction. While the compound's gastric antisecretory action has been attributed in part to inhibition of gastric adenylate cyclase and the gastric proton-transport
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7872202bebe8461846ddd068c83c0f5c
https://doi.org/10.3181/00379727-176-41897
https://doi.org/10.3181/00379727-176-41897
Autor:
Anne P. Drexler, Alan F. Moore
Publikováno v:
Drug Development Research. 2:241-250
This study was designed to determine the role of brain cholinergic mechanisms in the centrally mediated blood pressure and drinking responses to angiotensin II (ANG II). Atropine (10 mg/kg, IV), but not methyl atropine (8 mg/kg, IV), significantly in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9f0df9435e4df327f44bb487a16d2aad
https://doi.org/10.1002/ddr.430020304
https://doi.org/10.1002/ddr.430020304
Autor:
Schwe Fang Pong, Ralph L. White, Chau Ting Huang, Alan F. Moore, Robert R. Brooks, James R. Skuster
Publikováno v:
Drug Development Research. 7:141-151
EU-5476 is a new, orally active angiotensin I-converting enzyme (ACE) inhibitor. In vitro, EU-5476 produced a concentration-dependent inhibition of ACE purified from rabbit lung (IC50 = 0.084 μ). Inhibition showed complex kinetics and was reversible
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f56aa193b81d8bc03a6610481414dbec
https://doi.org/10.1002/ddr.430070205
https://doi.org/10.1002/ddr.430070205
Publisher Summary This chapter discusses certain specialized receptor substances in tissues, with which drugs interact to produce a response. Cells are equipped with chemically reactive groups, with which drug molecules react as the first step in a b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c62884e180abee7ea02d5acf938c7fc3
https://doi.org/10.1016/b978-0-08-020933-3.50006-4
https://doi.org/10.1016/b978-0-08-020933-3.50006-4
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America. 74(12)
Evidence of selective inhibition, differences in dose-response relationships, and cross-tachyphylaxis studies suggest that separate receptors and/or mechanisms may be involved in responses to angiotensin (Ang), [Sar1]Ang II, and Ang III (= des-Asp1-A
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c3d58fcf798b5cd8514c72ff5d4a238c
https://pubmed.ncbi.nlm.nih.gov/271997
https://pubmed.ncbi.nlm.nih.gov/271997
Publikováno v:
Clinical and experimental hypertension. Part A, Theory and practice. 7(1)
Among 1443 children, aged 5 to 18, followed for five consecutive years, we identified 68 who tracked consistently in the lowest blood pressure (BP) quartile and 114 in the highest. BP and corresponding heart rate were taken with subjects in the supin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::611958a5be685ae9ef5e50ffd9a42062
https://pubmed.ncbi.nlm.nih.gov/3995783
https://pubmed.ncbi.nlm.nih.gov/3995783