Zobrazeno 1 - 10
of 121
pro vyhledávání: '"Alan F Horwitz"'
Autor:
Marcelo L Lamers, Maíra E S Almeida, Miguel Vicente-Manzanares, Alan F Horwitz, Marinilce F Santos
Publikováno v:
PLoS ONE, Vol 6, Iss 8, p e22865 (2011)
Deficient wound healing in diabetic patients is very frequent, but the cellular and molecular causes are poorly defined. In this study, we evaluate the hypothesis that high glucose concentrations inhibit cell migration. Using CHO.K1 cells, NIH-3T3 fi
Externí odkaz:
https://doaj.org/article/0343d2b534d04202b6324d113d78c609
Publikováno v:
PLoS Computational Biology, Vol 6, Iss 2, p e1000688 (2010)
Productive cell migration requires the spatiotemporal coordination of cell adhesion, membrane protrusion, and actomyosin-mediated contraction. Integrins, engaged by the extracellular matrix (ECM), nucleate the formation of adhesive contacts at the ce
Externí odkaz:
https://doaj.org/article/d121f5e5daca4c3f81c081ba92df8aef
Publikováno v:
Signaling through Cell Abhesion Molecules
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1bb64d086e87d348508d0f4e8eb88f43
https://doi.org/10.1201/9780429129384-10
https://doi.org/10.1201/9780429129384-10
Autor:
Alan F. Horwitz, Leanna Whitmore, Miguel Vicente-Manzanares, Marcelo Lazzaron Lamers, Margaret A. Koach
Publikováno v:
The Journal of Cell Biology
We have found that MLC-dependent activation of myosin IIB in migrating cells is required to form an extended rear, which coincides with increased directional migration. Activated myosin IIB localizes prominently at the cell rear and produces large, s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3982f6e93ce09cba44311bf13c5d1c14
https://doi.org/10.1083/jcb.200806030
https://doi.org/10.1083/jcb.200806030
Publikováno v:
ACS Nano. 2:1252-1258
Difluoroboron dibenzoylmethane-polylactide, BF(2)dbmPLA, a biocompatible polymer-luminophore conjugate was fabricated as nanoparticles. Spherical particles100 nm in size were generated via nanoprecipitation. Intense blue fluorescence, two-photon abso
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::98b4198934431098518fbbcd1cdff859
https://doi.org/10.1021/nn7003525
https://doi.org/10.1021/nn7003525
Autor:
Nicholas E. Sherman, Joy M. Polefrone, Kristina Nelson, J. Thomas Parsons, Donald F. Hunt, Jeffrey Shabanowitz, Erin D. Jeffery, Alan F. Horwitz, Mark W. Mayhew, Stephen J. Pratt, Jay W. Fox
Publikováno v:
Journal of Cell Science. 120:3911-3918
βPIX (PAK1-interacting exchange factor beta, encoded by ARHGEF7 ) and PAK1 (p21 activated kinase) are interacting proteins that form a signaling module that mediates a number of cellular activities pertinent to cell migration ([Kim et al., 2001][1];
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a43674adec75aa6d61d93e554e5fbd3c
https://doi.org/10.1242/jcs.008177
https://doi.org/10.1242/jcs.008177
Publikováno v:
Journal of Biological Chemistry. 282:6929-6935
The actin-based dynamics of dendritic spines play a key role in synaptic plasticity, which underlies learning and memory. Although it is becoming increasingly clear that modulation of actin is critical for spine dynamics, the upstream molecular signa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::892cd26dbdd97946ffcc323330c69d53
https://doi.org/10.1074/jbc.m610981200
https://doi.org/10.1074/jbc.m610981200
Publikováno v:
The Journal of Cell Biology
We have used isoform-specific RNA interference knockdowns to investigate the roles of myosin IIA (MIIA) and MIIB in the component processes that drive cell migration. Both isoforms reside outside of protrusions and act at a distance to regulate cell
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3d838d3361e2ca59e1c081669af85640
https://doi.org/10.1083/jcb.200612043
https://doi.org/10.1083/jcb.200612043
Autor:
Alan F. Horwitz, Miguel Vicente-Manzanares, Brianne J. Ray, Fiona J. Pixley, J. Thomas Parsons, Amy H. Bouton, Katherine A. Owen, Keena S. Thomas, E. Richard Stanley, Hilary E. Beggs
Publikováno v:
The Journal of Cell Biology
Macrophages are a key component of the innate immune system. In this study, we investigate how focal adhesion kinase (FAK) and the related kinase Pyk2 integrate adhesion signaling and growth factor receptor signaling to regulate diverse macrophage fu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::786c4af90cab2ab3f7c19b42471a6e43
http://europepmc.org/articles/PMC2140030
http://europepmc.org/articles/PMC2140030
Publikováno v:
The Journal of Cell Biology
A recent meeting entitled Frontiers in Live Cell Imaging was attended by more than 400 cell biologists, physicists, chemists, mathematicians, and engineers. Unlike typical special topics meetings, which bring together investigators in a defined field
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::52863857ed0d81fc39a3ad54960d613b
http://europepmc.org/articles/PMC2064253
http://europepmc.org/articles/PMC2064253