Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Alan F Haughan"'
Autor:
Maria Beconi, Omar Aziz, Kim Matthews, Lara Moumné, Catherine O'Connell, Dawn Yates, Steven Clifton, Hannah Pett, Julie Vann, Lynsey Crowley, Alan F Haughan, Donna L Smith, Ben Woodman, Gillian P Bates, Fred Brookfield, Roland W Bürli, George McAllister, Celia Dominguez, Ignacio Munoz-Sanjuan, Vahri Beaumont
Publikováno v:
PLoS ONE, Vol 7, Iss 9, p e44498 (2012)
Histone deacetylase (HDAC) inhibitors have received considerable attention as potential therapeutics for a variety of cancers and neurological disorders. Recent publications on a class of pimelic diphenylamide HDAC inhibitors have highlighted their p
Externí odkaz:
https://doaj.org/article/65e55963f962453d81bddb172d9b42fa
Autor:
Tammy Ladduwahetty, Matthew R. Lee, Michel C. Maillard, Roger Cachope, Daniel Todd, Michael Barnes, Vahri Beaumont, Alka Chauhan, Caroline Gallati, Alan F. Haughan, Georg Kempf, Christopher A. Luckhurst, Kim Matthews, George McAllister, Philip Mitchell, Hiral Patel, Mark Rose, Elizabeth Saville-Stones, Stefan Steinbacher, Andrew J. Stott, Emma Thatcher, Jason Tierney, Liudvikas Urbonas, Ignacio Munoz-Sanjuan, Celia Dominguez
Publikováno v:
Journal of medicinal chemistry. 65(14)
The Rho kinase (ROCK) pathway is implicated in the pathogenesis of several conditions, including neurological diseases. In Huntington's disease (HD), ROCK is implicated in mutant huntingtin (HTT) aggregation and neurotoxicity, and members of the ROCK
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::828c256846fb4f8cb363fd87248c71f6
https://pubmed.ncbi.nlm.nih.gov/35816678
https://pubmed.ncbi.nlm.nih.gov/35816678
Autor:
Christopher A. Luckhurst, Omar Aziz, Vahri Beaumont, Roland W. Bürli, Perla Breccia, Michel C. Maillard, Alan F. Haughan, Marieke Lamers, Phil Leonard, Kim L. Matthews, Gilles Raphy, Andrew J. Stott, Ignacio Munoz-Sanjuan, Beth Thomas, Michael Wall, Grant Wishart, Dawn Yates, Celia Dominguez
Publikováno v:
Bioorganicmedicinal chemistry letters. 29(1)
We have identified a potent, cell permeable and CNS penetrant class IIa histone deacetylase (HDAC) inhibitor 22, with500-fold selectivity over class I HDACs (1,2,3) and ∼150-fold selectivity over HDAC8 and the class IIb HDAC6 isoform. Dose escalati
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::afc52289ed1bc17170b0a3a38854cb42
https://pubmed.ncbi.nlm.nih.gov/30463802
https://pubmed.ncbi.nlm.nih.gov/30463802
Publikováno v:
Tetrahedron. 63:2729-2737
In contrast to the corresponding hydroxyiodination reactions, the reaction of acetoxycyclohex-2-ene 1 with N-PSP in the presence of water shows little regiocontrol, but is highly diastereoselective. However, the same reaction of the (R)-phenylglycina
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a8209974669d189033a3486ff7586082
https://doi.org/10.1016/j.tet.2006.12.035
https://doi.org/10.1016/j.tet.2006.12.035
Publikováno v:
Tetrahedron Letters. 35:1781-1784
The reaction of acetoxycyclohexene with N-phenylselenophthalimide in the presence of water is non-regiospecific, in contrast to the previously reported chloroselenation reaction.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e2e64e28ca8acfec426eb64d237a587a
https://doi.org/10.1016/0040-4039(94)88345-9
https://doi.org/10.1016/0040-4039(94)88345-9
Diastereospecific hydroxyiodination of 1-acetoxycyclohex-2-ene via intramolecular delivery of oxygen
Publikováno v:
Tetrahedron Letters. 35:1405-1408
The previously unreported reaction of N-iodosuccinimide with acetoxycyclohex-2-ene to give monoacetates of 3-iodocyclohexane-1,2-diols is diastereospecific.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2ebecca6d0f466c3c02526dc049e7bbc
https://doi.org/10.1016/s0040-4039(00)76230-7
https://doi.org/10.1016/s0040-4039(00)76230-7
Autor:
Joseph B. Sweeney, Alan F. Haughan
Publikováno v:
Tetrahedron: Asymmetry. 5:177-180
Cyclohex-2-enyl esters of homochiral (R)-Z-phenylglycine undergo completely regio- and diastereospecific addition reactions with N-phenylselenophthalimide. The resulting selenoalcohols are separable by routine chromatography and may be converted into
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1935168f5926ad9509b4faffed0fd7c1
https://doi.org/10.1016/s0957-4166(00)86166-2
https://doi.org/10.1016/s0957-4166(00)86166-2
Publikováno v:
ChemInform. 25
The reaction of acetoxycyclohexene with N-phenylselenophthalimide in the presence of water is non-regiospecific, in contrast to the previously reported chloroselenation reaction.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5b44132f5008dba4b1973dfd87ecf17b
https://doi.org/10.1002/chin.199434112
https://doi.org/10.1002/chin.199434112
Autor:
Joseph B. Sweeney, Alan F. Haughan
Publikováno v:
ChemInform. 25
Cyclohex-2-enyl esters of homochiral (R)-Z-phenylglycine undergo completely regio- and diastereospecific addition reactions with N-phenylselenophthalimide. The resulting selenoalcohols are separable by routine chromatography and may be converted into
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a75fd43dd77e493c524f0acb023507fd
https://doi.org/10.1002/chin.199428052
https://doi.org/10.1002/chin.199428052
Publikováno v:
ChemInform. 25
The previously unreported reaction of N-iodosuccinimide with acetoxycyclohex-2-ene to give monoacetates of 3-iodocyclohexane-1,2-diols is diastereospecific.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5b3386e053d570cae14c91323fbb21d0
https://doi.org/10.1002/chin.199428146
https://doi.org/10.1002/chin.199428146