Key discoveries in bile acid chemistry and biology and their clinical applications: history of the last eight decades

Autor: Alan F. Hofmann, Lee R. Hagey

Publikováno v: Journal of Lipid Research, Vol 55, Iss 8, Pp 1553-1595 (2014)

During the last 80 years there have been extraordinary advances in our knowledge of the chemistry and biology of bile acids. We present here a brief history of the major achievements as we perceive them. Bernal, a physicist, determined the X-ray stru

Externí odkaz: https://doaj.org/article/71574a5f9f2d477290ec5736da47ae67

Obeticholic acid improves hepatic bile acid excretion in patients with primary biliary cholangitis

Autor: Alan F. Hofmann, Mary Erickson, Kristoffer Kjærgaard, Susanne Keiding, David Shapiro, Michael Sørensen, Anna C. Schacht, Ole Lajord Munk, Jacob Horsager, Kim Frisch

Publikováno v: Kjærgaard, K, Frisch, K, Sørensen, M, Munk, O L, Hofmann, A F, Horsager, J, Schacht, A C, Erickson, M, Shapiro, D A & Keiding, S 2021, ' Obeticholic acid improves hepatic bile acid excretion in patients with primary biliary cholangitis ', Journal of Hepatology, vol. 74, no. 1, pp. 58-65 . https://doi.org/10.1016/j.jhep.2020.07.028

Background & Aims: Obeticholic acid (OCA) is an agonist of the nuclear bile acid receptor farnesoid X receptor, which regulates hepatic bile acid metabolism. We tested whether OCA treatment would influence hepatic transport of conjugated bile acids i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a8852637514a0cfe3f5190f789668a8c
https://doi.org/10.1016/j.jhep.2020.07.028

A new, major C27 biliary bile acid in the Red-winged tinamou (Rhynchotus rufescens):(25R)-1β,3α,7α-trihydroxy-5β-cholestan-27-oic acid

Autor: Lee R. Hagey, Genta Kakiyama, Akina Muto, Takashi Iida, Kumiko Mushiake, Takaaki Goto, Nariyasu Mano, Junichi Goto, Cleida A. Oliveira, Alan F. Hofmann

Publikováno v: Journal of Lipid Research, Vol 50, Iss 4, Pp 651-657 (2009)

The chemical structures of the three major bile acids present in the gallbladder bile of the Red-winged tinamou (Rhynchotus rufescens), an early evolving, ground-living bird related to ratites, were determined. Bile acids were isolated by preparative

Externí odkaz: https://doaj.org/article/fadaeaf39e6f48db83e005db9b4df3bd

Isolation and chemical synthesis of a major, novel biliary bile acid in the common wombat (Vombatus ursinus): 15α-hydroxylithocholic acid

Autor: Genta Kakiyama, Hideyuki Tamegai, Takashi Iida, Kuniko Mitamura, Shigeo Ikegawa, Takaaki Goto, Nariyasu Mano, Junichi Goto, Peter Holz, Lee R. Hagey, Alan F. Hofmann

Publikováno v: Journal of Lipid Research, Vol 48, Iss 12, Pp 2682-2692 (2007)

The major bile acids present in the gallbladder bile of the common Australian wombat (Vombatus ursinus) were isolated by preparative HPLC and identified by NMR as the taurine N-acylamidates of chenodeoxycholic acid (CDCA) and 15α-hydroxylithocholic

Externí odkaz: https://doaj.org/article/3958941c4b8d4677a6ad615348334063

Two loci on chromosome 9 control bile acid composition: evidence that a strong candidate gene, Cyp8b1, is not the culprits⃞

Autor: Ephraim Sehayek, Lee R. Hagey, Yee-Yan Fung, Elizabeth M. Duncan, Hannah J. Yu, Gösta Eggertsen, Ingemar Björkhem, Alan F. Hofmann, Jan L. Breslow

Publikováno v: Journal of Lipid Research, Vol 47, Iss 9, Pp 2020-2027 (2006)

An intercross between C57BL/6J and CASA/Rk mice was used to study the genetics of biliary bile acid composition. In parental strains, male C57BL/6J mice had significantly higher cholic acid (CA; 14%) and lower β-muricholic acid (βMC; 27%) than CASA

Externí odkaz: https://doaj.org/article/d1aa8ae5867a44ae853af8cdf3ad74eb