Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Alan E. Fletcher"'
Autor:
John R. Atack, Julie Kerby, Alison J. Smith, George R. Marshall, Jonathan Silk, Ruth M. McKernan, Alan E. Fletcher, Tim Scales, Luanda Alder, Keith A. Wafford, Charles E. Adkins
Publikováno v:
Molecular Pharmacology. 59:1108-1118
Inhibitory gamma-aminobutyric acid (GABA)(A) receptors are subject to modulation at a variety of allosteric sites, with pharmacology dependent on receptor subunit combination. The influence of different alpha subunits in combination with beta3gamma2s
Autor:
Kevin W. Moore, Robert W. Carling, F. Emms, Bindi Sohal, Paul D. Leeson, Smita Patel, R. Marwood, Elizabeth A. Jones, Margaret S. Beer, Christopher Moyes, Shil Patel, Alan E. Fletcher, Katrine Bonner, and Andrew Pike
Publikováno v:
Journal of Medicinal Chemistry. 42:2706-2715
After the requirement of pseudocycle formation in the ureas 3 and 7 for hD(4) binding and selectivity was confirmed, structural hybridization with the known hD(4) ligand 2 led to the design and identification of the lead 4-(2-oxo-1, 3-dihydroimidazol
Autor:
Stephen B. Freedman, Kerry L. Chapman, Kate Scholey, George R. Marshall, Mark G. Bock, Roger M. Freidinger, Richard Hargreaves, Robert M. DiPardo, Alan E. Fletcher, John A. Kemp, S. Patel, E. C. Mellin, Alison J. Smith
Publikováno v:
Annals of the New York Academy of Sciences. 713:312-318
The profile of an acidic series of benzodiazepine CCK-B receptor antagonists is described. The tetrazolyl urea derivative L-368,935 had high affinity (CCK-B IC50 0.1 nM) and was one of the most selective (CCK-B/CCK-A 10,000) CCK-B antagonists known.
Autor:
Howard B. Broughton, Denise Rathbone, Raymond Baker, Alan E. Fletcher, Alison J. Smith, Richard G. Ball, Kerry L. Chapman, José L. Castro, Smita Patel, Michael G. N. Russell, Alan P. Watt, George R. Marshall, W. Ryecroft, Victor G. Matassa
Publikováno v:
ChemInform. 27
The design, synthesis, and biological activity of a novel series of CCK-B receptor antagonists (1) which incorporate a tetrazol-5-ylamino functionality attached to the phenyl ring of the arylurea moiety of L-365,260 are described. In these compounds,
Autor:
Mark G. Bock, Robert M. DiPardo, Eva C. Mellin, Randall C. Newton, Daniel F. Veber, Stephen B. Freedman, Alison J. Smith, Smita Patel, John A. Kemp, George R. Marshall, Alan E. Fletcher, Kerry L. Chapman, Paul S. Anderson, Roger M. Freidinger
Publikováno v:
Journal of Medicinal Chemistry. 37:722-724
Autor:
Ian Collins, F. Emms, Smita Patel, Michael Rowley, Joseph G. Neduvelil, Kerry L. Chapman, Graham Andrew Showell, Paul D. Leeson, Sylvie Bourrain, Shil Patel, Alan E. Fletcher, Rosemarie Marwood
Publikováno v:
Bioorganicmedicinal chemistry. 6(10)
Two novel series of 3-(heterocyclylmethyl)pyrazoles have been synthesised and evaluated as ligands for the human dopamine D4 receptor. Compounds in series I (exemplified by 8k) have a phenyl ring joined to the 4-position of the pyrazole while those i
Autor:
Ian Collins, Michael Rowley, Alan E. Fletcher, William B Davey, Ann L Scott, Rosemarie Marwood, Shil Patel, F. Emms, Paul D. Leeson, Theodore P. Broten, Ian C. Ragan, Smita Patel
Publikováno v:
Bioorganicmedicinal chemistry. 6(6)
3-(4-Piperidinyl)-5-arylpyrazoles, such as 1, were selective for the cloned human dopamine D4 receptor (hD4), but also showed affinity at voltage sensitive calcium, sodium and potassium ion channels. A combination of substituent changes to reduce the
Autor:
Alison J. Smith, Alan P. Watt, Denise Rathbone, Raymond Baker, Howard B. Broughton, Alan E. Fletcher, José L. Castro, W. Ryecroft, Richard G. Ball, Victor G. Matassa, George R. Marshall, Michael G. N. Russell, Smita Patel, Kerry L. Chapman
Publikováno v:
Journal of medicinal chemistry. 39(4)
The design, synthesis, and biological activity of a novel series of CCK-B receptor antagonists (1) which incorporate a tetrazol-5-ylamino functionality attached to the phenyl ring of the arylurea moiety of L-365,260 are described. In these compounds,