Zobrazeno 1 - 10
of 180
pro vyhledávání: '"Alan E Mast"'
Autor:
Alan E Mast, Alisa S Wolberg, David Gailani, Michael R Garvin, Christiane Alvarez, J Izaak Miller, Piet Jones, Bruce Aronow, Daniel Jacobson
Publikováno v:
eLife, Vol 11 (2022)
Early in the SARS-CoV-2 pandemic, we compared transcriptome data from hospitalized COVID-19 patients and control patients without COVID-19. We found changes in procoagulant and fibrinolytic gene expression in the lungs of COVID-19 patients (Mast et a
Externí odkaz:
https://doaj.org/article/6f80d1bcca304f5ab500cec044ad3eb3
Autor:
Alan E Mast, Alisa S Wolberg, David Gailani, Michael R Garvin, Christiane Alvarez, J Izaak Miller, Bruce Aronow, Daniel Jacobson
Publikováno v:
eLife, Vol 10 (2021)
Extensive fibrin deposition in the lungs and altered levels of circulating blood coagulation proteins in COVID-19 patients imply local derangement of pathways that limit fibrin formation and/or promote its clearance. We examined transcriptional profi
Externí odkaz:
https://doaj.org/article/c9cf14268af2449ebec4df152af85aff
Autor:
Michael R Garvin, Christiane Alvarez, J Izaak Miller, Erica T Prates, Angelica M Walker, B Kirtley Amos, Alan E Mast, Amy Justice, Bruce Aronow, Daniel Jacobson
Publikováno v:
eLife, Vol 9 (2020)
Neither the disease mechanism nor treatments for COVID-19 are currently known. Here, we present a novel molecular mechanism for COVID-19 that provides therapeutic intervention points that can be addressed with existing FDA-approved pharmaceuticals. T
Externí odkaz:
https://doaj.org/article/7ca8502352754188ae4bff950a8b4f2e
Autor:
Fang Fang, Kelsey Hazegh, Alan E. Mast, Darrell J. Triulzi, Bryan R. Spencer, Mark T. Gladwin, Michael P. Busch, Tamir Kanias, Grier P. Page
Publikováno v:
BMC Genomics, Vol 23, Iss 1, Pp 1-8 (2022)
Abstract Background Genetic variants have been found to influence red blood cell (RBC) susceptibility to hemolytic stress and affect transfusion outcomes and the severity of blood diseases. Males have a higher susceptibility to hemolysis than females
Externí odkaz:
https://doaj.org/article/fa7d522815814867aa453a23c91ff198
Autor:
Maria Didriksen, Muhammad Sulaman Nawaz, Joseph Dowsett, Steven Bell, Christian Erikstrup, Ole B. Pedersen, Erik Sørensen, Poul J. Jennum, Kristoffer S. Burgdorf, Brendan Burchell, Adam S. Butterworth, Nicole Soranzo, David B. Rye, Lynn Marie Trotti, Prabhjyot Saini, Lilja Stefansdottir, Sigurdur H. Magnusson, Gudmar Thorleifsson, Thordur Sigmundsson, Albert P. Sigurdsson, Katja Van Den Hurk, Franke Quee, Michael W. T. Tanck, Willem H. Ouwehand, David J. Roberts, Eric J. Earley, Michael P. Busch, Alan E. Mast, Grier P. Page, John Danesh, Emanuele Di Angelantonio, Hreinn Stefansson, Henrik Ullum, Kari Stefansson
Publikováno v:
Communications Biology, Vol 3, Iss 1, Pp 1-9 (2020)
Didriksen, Nawaz, et al. identify three novel genetic risk variants for restless legs syndrome and confirm 19 out of 20 previously reported variants through a genome-wide association meta-analysis including nearly half a million individuals. Using ex
Externí odkaz:
https://doaj.org/article/b804eef352554c768c94ad94c5a8a74a
Autor:
Nareg H. Roubinian, Sarah E. Reese, Hannah Qiao, Colleen Plimier, Fang Fang, Grier P. Page, Ritchard G. Cable, Brian Custer, Mark T. Gladwin, Ruchika Goel, Bob Harris, Jeanne E. Hendrickson, Tamir Kanias, Steve Kleinman, Alan E. Mast, Steven R. Sloan, Bryan R. Spencer, Steven L. Spitalnik, Michael P. Busch, Eldad A. Hod, on behalf of the National Heart Lung and Blood Institute (NHLBI) Recipient Epidemiology and Donor Evaluation Study IV Pediatrics (REDS-IV-P)
Publikováno v:
JCI Insight, Vol 7, Iss 1 (2022)
BACKGROUND RBC transfusion effectiveness varies due to donor, component, and recipient factors. Prior studies identified characteristics associated with variation in hemoglobin increments following transfusion. We extended these observations, examini
Externí odkaz:
https://doaj.org/article/5ffdf656ec2b41cf83837f34b918c2f3
Autor:
Susan A. Maroney, Amy E. Siebert, Nicholas D. Martinez, Mark Rasmussen, Julie A. Peterson, Hartmut Weiler, Joy Lincoln, Alan E. Mast
Publikováno v:
Journal of Thrombosis and Haemostasis. 21:639-651
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0dc9f347be9ac020c9af89aa7d7fdd8e
https://doi.org/10.1016/j.jtha.2022.11.034
https://doi.org/10.1016/j.jtha.2022.11.034
Autor:
Stéphanie E. Reitsma, Lori A. Holle, Emma G. Bouck, Dougald M. Monroe, Alan E. Mast, John Burthem, Paula H.B. Bolton-Maggs, Gillian N. Gidley, Alisa S. Wolberg
Publikováno v:
Journal of Thrombosis and Haemostasis. 21:467-479
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9bb2becf854529db7ec7b969a8ada21f
https://doi.org/10.1016/j.jtha.2022.10.005
https://doi.org/10.1016/j.jtha.2022.10.005
Publikováno v:
Blood Advances, Vol 1, Iss 27, Pp 2692-2702 (2017)
Abstract: Tissue factor pathway inhibitor α (TFPIα) inhibits prothrombinase, the thrombin-generating complex of factor Xa (FXa) and factor Va (FVa), during the initiation of coagulation. This inhibition requires binding of a conserved basic region
Externí odkaz:
https://doaj.org/article/b80cab3955024d39919b18c5139417a1
Autor:
Tamir Kanias, Marion C. Lanteri, Grier P. Page, Yuelong Guo, Stacy M. Endres, Mars Stone, Sheila Keating, Alan E. Mast, Ritchard G. Cable, Darrell J. Triulzi, Joseph E. Kiss, Edward L. Murphy, Steve Kleinman, Michael P. Busch, Mark T. Gladwin
Publikováno v:
Blood Advances, Vol 1, Iss 15, Pp 1132-1141 (2017)
Abstract: Genetic polymorphisms in blood donors may contribute to donor-specific differences in the survival of red blood cells (RBCs) during cold storage and after transfusion. Genetic variability is anticipated to be high in donors with racial admi
Externí odkaz:
https://doaj.org/article/4b37487facb4411ca6f6feb6165689bf