Výsledky vyhledávání - "Alan E Hoban"

Akademický článek

Social interaction-induced activation of RNA splicing in the amygdala of microbiome-deficient mice

Autor: Roman M Stilling, Gerard M Moloney, Feargal J Ryan, Alan E Hoban, Thomaz FS Bastiaanssen, Fergus Shanahan, Gerard Clarke, Marcus J Claesson, Timothy G Dinan, John F Cryan

Publikováno v: eLife, Vol 7 (2018)

Social behaviour is regulated by activity of host-associated microbiota across multiple species. However, the molecular mechanisms mediating this relationship remain elusive. We therefore determined the dynamic, stimulus-dependent transcriptional reg

Externí odkaz: https://doaj.org/article/e259a28345df44e49b5200bc4b476940

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Enduring Behavioral Effects Induced by Birth by Caesarean Section in the Mouse

Publikováno v: Current Biology, 30(19), 3761-3774. CELL PRESS
Current Biology, 30(19), 3761-3774.e6
Current Biology 30 (2020) 19

Birth by Caesarean (C)-section impacts early gut microbiota colonization and is associated with an increased risk of developing immune and metabolic disorders. Moreover, alterations of the microbiome have been shown to affect neurodevelopmental traje

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8c3f7acb609b10976ac67ca9dacf9f8d
https://research.rug.nl/en/publications/89ae24da-1318-4766-9522-0f12bf802ffd

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Host Microbiota Regulates Central Nervous System Serotonin Receptor 2C Editing in Rodents

Autor: Gerard Clarke, John F. Cryan, Roman M. Stilling, Veronica L. Peterson, Timothy G. Dinan, Feargal J. Ryan, Marcus J. Claesson, Harriët Schellekens, Fergus Shanahan, Marcel van de Wouw, Alan E. Hoban

Publikováno v: ACS Chemical Neuroscience. 10:3953-3960

Microbial colonization of the gastrointestinal tract plays a crucial role in the development of enteric and central nervous system functionality. The serotonergic system has been heavily implicated in microbiota–gut–brain axis signaling, particul

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::67a2840bb50727d5efc9a5574ca91777
https://doi.org/10.1021/acschemneuro.9b00414

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Differential effects of adolescent and adult-initiated voluntary exercise on context and cued fear conditioning

Autor: Alan E. Hoban, Olivia F. O’Leary, James D. O'Leary, Yvonne M. Nolan, John F. Cryan

Publikováno v: Neuropharmacology. 145:49-58

Adolescence is a critical period for postnatal brain maturation and a time during which there is increased susceptibility to developing emotional and cognitive-related disorders. Exercise during adulthood has been shown to increase hippocampal plasti

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e397c791494a23594327a73ee9ec6228
https://doi.org/10.1016/j.neuropharm.2018.05.007

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Gut microbiota modulates expression of genes involved in the astrocyte-neuron lactate shuttle in the hippocampus

Autor: John F. Cryan, Eoin Sherwin, Pierre J. Magistretti, Michael B. Margineanu, Hubert Fiumelli, Alan E. Hoban, Anna V. Golubeva, Veronica L. Peterson, Kieran Rea

The gut microbiota modulates brain physiology, development, and behavior and has been implicated as a key regulator in several central nervous system disorders. Its effect on the metabolic coupling between neurons and astrocytes has not been studied

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c1693731d3cb736bf64d08abada4766c
https://hdl.handle.net/10468/13024

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Lactobacillus rhamnosus GG soluble mediators ameliorate early life stress-induced visceral hypersensitivity and changes in spinal cord gene expression

Autor: Siobhain M. O'Mahony, Matteo M. Pusceddu, Gerry Moloney, Rosaline Waworuntu, Conall R. Strain, Kiera Murphy, Catherine Stanton, Alan E. Hoban, John F. Cryan, Sarmauli Manurung, Gabriele Gross, Karen-Anne McVey Neufeld, Timothy G. Dinan

Publikováno v: Neuronal Signaling

Visceral hypersensitivity is a hallmark of many functional and stress-related gastrointestinal disorders, and there is growing evidence that the gut microbiota may play a role in its pathophysiology. It has previously been shown that early life stres

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aff7f0c62c8a40332b0265d4074df5c9
http://europepmc.org/articles/PMC7726314

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Enduring effects of an unhealthy diet during adolescence on systemic but not neurobehavioural measures in adult rats

Autor: Ciarán S. Ó. Léime, Alan E. Hoban, Cara M. Hueston, John F. Cryan, Sarah Nicolas, Yvonne M. Nolan

Introduction: Adolescence is an important stage of maturation for various brain structures. It is during this time therefore that the brain may be more vulnerable to environmental factors such as diet that may influence mood and memory. Diets high in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1ff5da6d935b463355178cc4314978a7
https://hdl.handle.net/10468/10479

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Microbial regulation of microRNA expression in the amygdala and prefrontal cortex

Autor: Gerard Clarke, Alan E. Hoban, Timothy G. Dinan, Gerard M. Moloney, Rachel D. Moloney, Roman M. Stilling, John F. Cryan, Fergus Shanahan

Publikováno v: Microbiome, Vol 5, Iss 1, Pp 1-11 (2017)
Microbiome

Background There is growing evidence for a role of the gut microbiome in shaping behaviour relevant to many psychiatric and neurological disorders. Preclinical studies using germ-free (GF) animals have been essential in contributing to our current un

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::13d38e1ee3bac2419ce49bd929369189
http://link.springer.com/article/10.1186/s40168-017-0321-3

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