Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Alan E Bilsland"'
Autor:
Claire J Cairney, Lauren S Godwin, Alan E Bilsland, Sharon Burns, Katrina H Stevenson, Lynn McGarry, John Revie, Jon D Moore, Ceri M Wiggins, Rebecca S Collinson, Clare Mudd, Elpida Tsonou, Mahito Sadaie, Dorothy C Bennett, Masashi Narita, Christopher J Torrance, W Nicol Keith
Publikováno v:
PLoS Genetics, Vol 13, Iss 8, p e1006942 (2017)
Senescence is a universal barrier to immortalisation and tumorigenesis. As such, interest in the use of senescence-induction in a therapeutic context has been gaining momentum in the past few years; however, senescence and immortalisation remain unde
Externí odkaz:
https://doaj.org/article/9c37fdc4728e4b2584673b3d2d9b5b8b
Autor:
Alan E Bilsland, Katrina Stevenson, Yu Liu, Stacey Hoare, Claire J Cairney, Jon Roffey, W Nicol Keith
Publikováno v:
PLoS Computational Biology, Vol 10, Iss 2, p e1003448 (2014)
Cancer cells depend on transcription of telomerase reverse transcriptase (TERT). Many transcription factors affect TERT, though regulation occurs in context of a broader network. Network effects on telomerase regulation have not been investigated, th
Externí odkaz:
https://doaj.org/article/12af634056c54dc780e056ce775e8e7b
Autor:
Alan E Bilsland, Stacey Hoare, Katrina Stevenson, Jane Plumb, Natividad Gomez-Roman, Claire Cairney, Sharon Burns, Kyle Lafferty-Whyte, Jon Roffey, Tim Hammonds, W Nicol Keith
Publikováno v:
PLoS ONE, Vol 4, Iss 7, p e6459 (2009)
Telomerase controls telomere homeostasis and cell immortality and is a promising anti-cancer target, but few small molecule telomerase inhibitors have been developed. Reactivated transcription of the catalytic subunit hTERT in cancer cells controls t
Externí odkaz:
https://doaj.org/article/1b41ea64dd364875a5dfb77a3f62bf69
Publikováno v:
RSC Medicinal Chemistry. 13:1205-1211
We recently reported a deep learning model to facilitate fragment library design, which is critical for efficient hit identification. However, our model was implemented in Python. We have now created an implementation in the KNIME graphical pipelinin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2d084c0fa90dbc0b35f77a1bd130a242
https://doi.org/10.1039/d2md00152g
https://doi.org/10.1039/d2md00152g
Publikováno v:
F1000Research, Vol 5 (2016)
For decades, effective cancer gene therapy has been a tantalising prospect; for a therapeutic modality potentially able to elicit highly effective and selective responses, definitive efficacy outcomes have often seemed out of reach. However, steady p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doajarticles::8ce539d15baf520395be060afad4a744
http://f1000research.com/articles/5-2105/v1
http://f1000research.com/articles/5-2105/v1
Autor:
Alan E. Bilsland, Yu Liu, Andrew Turnbull, David Sumpton, Katrina Stevenson, Claire J. Cairney, Susan M. Boyd, Jon Roffey, David Jenkinson, W. Nicol Keith
Publikováno v:
Neoplasia: An International Journal for Oncology Research, Vol 21, Iss 9, Pp 893-907 (2019)
Telomere signaling and metabolic dysfunction are hallmarks of cell aging. New agents targeting these processes might provide therapeutic opportunities, including chemoprevention strategies against cancer predisposition. We report identification and c
Externí odkaz:
https://doaj.org/article/936206170ac349faab43d8b1ddaedfcd
Autor:
Alan E. Bilsland, Angelo Pugliese, Yu Liu, John Revie, Sharon Burns, Carol McCormick, Claire J. Cairney, Justin Bower, Martin Drysdale, Masashi Narita, Mahito Sadaie, W. Nicol Keith
Publikováno v:
Neoplasia: An International Journal for Oncology Research, Vol 17, Iss 9, Pp 704-715 (2015)
Cellular senescence is a barrier to tumorigenesis in normal cells, and tumor cells undergo senescence responses to genotoxic stimuli, which is a potential target phenotype for cancer therapy. However, in this setting, mixed-mode responses are common
Externí odkaz:
https://doaj.org/article/f63495499283424f8b4feb22d3460e78
Publikováno v:
Neoplasia: An International Journal for Oncology Research, Vol 7, Iss 11, Pp 1020-1029 (2005)
Telomerase expression represents a good target for cancer gene therapy. The promoters of the core telomerase catalytic [human telomerase reverse transcriptase (hTERT)] and RNA [human telomerase RNA (hTR)] subunits show selective activity in cancer ce
Externí odkaz:
https://doaj.org/article/c08d137303514853a723ca27f3e65ce6