Zobrazeno 1 - 10
of 98
pro vyhledávání: '"Alan Dodson"'
Variant-proof high affinity ACE2 antagonist limits SARS-CoV-2 replication in upper and lower airways
Autor:
Matthew Gagne, Barbara J. Flynn, Christopher Cole Honeycutt, Dillon R. Flebbe, Shayne F. Andrew, Samantha J. Provost, Lauren McCormick, Alex Van Ry, Elizabeth McCarthy, John-Paul M. Todd, Saran Bao, I-Ting Teng, Shir Marciano, Yinon Rudich, Chunlin Li, Shilpi Jain, Bushra Wali, Laurent Pessaint, Alan Dodson, Anthony Cook, Mark G. Lewis, Hanne Andersen, Jiří Zahradník, Mehul S. Suthar, Martha C. Nason, Kathryn E. Foulds, Peter D. Kwong, Mario Roederer, Gideon Schreiber, Robert A. Seder, Daniel C. Douek
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-13 (2024)
Abstract SARS-CoV-2 has the capacity to evolve mutations that escape vaccine- and infection-acquired immunity and antiviral drugs. A variant-agnostic therapeutic agent that protects against severe disease without putting selective pressure on the vir
Externí odkaz:
https://doaj.org/article/398a2dfd9ac6483f881f1a81f6f17840
Autor:
Patrick J. Madden, Muhammad S. Arif, Mark E. Becker, Michael D. McRaven, Ann M. Carias, Ramon Lorenzo-Redondo, Sixia Xiao, Cecily C. Midkiff, Robert V. Blair, Elizabeth Lake Potter, Laura Martin-Sancho, Alan Dodson, Elena Martinelli, John-Paul M. Todd, Francois J. Villinger, Sumit K. Chanda, Pyone Pyone Aye, Chad J. Roy, Mario Roederer, Mark G. Lewis, Ronald S. Veazey, Thomas J. Hope
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
Infection with the novel coronavirus, SARS-CoV-2, results in pneumonia and other respiratory symptoms as well as pathologies at diverse anatomical sites. An outstanding question is whether these diverse pathologies are due to replication of the virus
Externí odkaz:
https://doaj.org/article/74bcab5e177646ac8a31e5c09bd2f86c
Autor:
Ami Patel, Jewell N. Walters, Emma L. Reuschel, Katherine Schultheis, Elizabeth Parzych, Ebony N. Gary, Igor Maricic, Mansi Purwar, Zeena Eblimit, Susanne N. Walker, Diana Guimet, Pratik Bhojnagarwala, Opeyemi S. Adeniji, Arthur Doan, Ziyang Xu, Dustin Elwood, Sophia M. Reeder, Laurent Pessaint, Kevin Y. Kim, Anthony Cook, Neethu Chokkalingam, Brad Finneyfrock, Edgar Tello-Ruiz, Alan Dodson, Jihae Choi, Alison Generotti, John Harrison, Nicholas J. Tursi, Viviane M. Andrade, Yaya Dia, Faraz I. Zaidi, Hanne Andersen, Mohamed Abdel-Mohsen, Mark G. Lewis, Kar Muthumani, J. Joseph Kim, Daniel W. Kulp, Laurent M. Humeau, Stephanie J. Ramos, Trevor R.F. Smith, David B. Weiner, Kate E. Broderick
Publikováno v:
Cell Reports Medicine, Vol 2, Iss 10, Pp 100420- (2021)
Summary: Coronavirus disease 2019 (COVID-19), caused by the SARS-CoV-2 virus, has had a dramatic global impact on public health and social and economic infrastructures. Here, we assess the immunogenicity and anamnestic protective efficacy in rhesus m
Externí odkaz:
https://doaj.org/article/b251aab9f925454e8c8c047ebbca4faa
Autor:
Kai Wu, Ian N. Moore, Bridget Bart, John-Paul Todd, Elham Bayat Mokhtari, Gabriela S. Alvarado, Swagata Kar, Jaclyn Wear, Manjari Sriparna, Kathryn E. Foulds, Matthew Gagne, Mario Roederer, Kizzmekia S. Corbett, Seyhan Boyoglu-Barnum, Darin K. Edwards, Barbara J. Flynn, Katelyn Steingrebe, Adrian B. McDermott, Samantha J. Provost, Angela Choi, Shayne F. Andrew, Eli Boritz, Sayda Elbashir, Zackery Flinchbaugh, Timothy S. Johnston, Martha Nason, Sarah O’ Connell, Anthony Cook, Bianca M. Nagata, Mahnaz Minai, Prakriti Mudvari, Mark G. Lewis, Andrew Pekosz, Amy R. Henry, Farida Laboune, Dillon R. Flebbe, Becky Chang, Alex Van Ry, Nancy J. Sullivan, Juan I. Moliva, Saule T. Nurmukhambetova, Laurent Pessaint, Lilin Lai, Matthew A. Koch, Barney S. Graham, Hanne Leth Andersen, Maciel Porto, Kevin W. Bock, Daniel C. Douek, Anne P. Werner, Mehul S. Suthar, Evan Lamb, Alan Dodson, Andrea Carfi, Robert A. Seder
Publikováno v:
Nature Immunology. 22:1306-1315
B.1.351 is the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variant most resistant to antibody neutralization. We demonstrate how the dose and number of immunizations influence protection. Nonhuman primates received two doses of 30 or
Autor:
Matthew Gagne, Juan I. Moliva, Kathryn E. Foulds, Shayne F. Andrew, Barbara J. Flynn, Anne P. Werner, Danielle A. Wagner, I-Ting Teng, Bob C. Lin, Christopher Moore, Nazaire Jean-Baptiste, Robin Carroll, Stephanie L. Foster, Mit Patel, Madison Ellis, Venkata-Viswanadh Edara, Nahara Vargas Maldonado, Mahnaz Minai, Lauren McCormick, Christopher Cole Honeycutt, Bianca M. Nagata, Kevin W. Bock, Caitlyn N. M. Dulan, Jamilet Cordon, John-Paul M. Todd, Elizabeth McCarthy, Laurent Pessaint, Alex Van Ry, Brandon Narvaez, Daniel Valentin, Anthony Cook, Alan Dodson, Katelyn Steingrebe, Dillon R. Flebbe, Saule T. Nurmukhambetova, Sucheta Godbole, Amy R. Henry, Farida Laboune, Jesmine Roberts-Torres, Cynthia G. Lorang, Shivani Amin, Jessica Trost, Mursal Naisan, Manjula Basappa, Jacquelyn Willis, Lingshu Wang, Wei Shi, Nicole A. Doria-Rose, Adam S. Olia, Cuiping Liu, Darcy R. Harris, Andrea Carfi, John R. Mascola, Peter D. Kwong, Darin K. Edwards, Hanne Andersen, Mark G. Lewis, Kizzmekia S. Corbett, Martha C. Nason, Adrian B. McDermott, Mehul S. Suthar, Ian N. Moore, Mario Roederer, Nancy J. Sullivan, Daniel C. Douek, Robert A. Seder
SummarySARS-CoV-2 Omicron is highly transmissible and has substantial resistance to antibody neutralization following immunization with ancestral spike-matched vaccines. It is unclear whether boosting with Omicron-specific vaccines would enhance immu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bf75ae434882f0dd8baa7a19d8b7db69
https://doi.org/10.1101/2022.02.03.479037
https://doi.org/10.1101/2022.02.03.479037
Autor:
Alan Dodson, Andrea Carfi, Robert A. Seder, Cynthia G. Lorang, Jesmine Roberts-Torres, Anthony L. Cook, Lauren McCormick, Darin K. Edwards, Anne P. Werner, Danielle A. Wagner, Wei Shi, Mehul S. Suthar, Kevin W. Bock, Bingchun Zhao, Shayne F. Andrew, Juan I. Moliva, Saule T. Nurmukhambetova, Eli Boritz, Laurent Pessaint, Courtney Tucker, Ian N. Moore, Elizabeth McCarthy, Adrienne Goode, Swagata Kar, Bianca M. Nagata, Hanne Leth Andersen, Christopher Cole Honeycutt, Prakriti Mudvari, Mark G. Lewis, Barbara J. Flynn, Daniel C. Douek, Farida Laboune, Seyhan Boyoglu-Barnum, John-Paul Todd, Eun Sung Yang, Mahnaz Minai, Kathryn E. Foulds, I-Ting Teng, Kizzmekia S. Corbett, Lingshu Wang, John R. Mascola, Barney S. Graham, Aurélie Ploquin, Meredith E. Davis-Gardner, Nancy J. Sullivan, Martha Nason, Matthew Gagne, Nicole A. Doria-Rose, Mario Roederer
Publikováno v:
Cell
bioRxiv
bioRxiv
mRNA-1273 vaccine efficacy against SARS-CoV-2 Delta wanes over time; however, there are limited data on the impact of durability of immune responses on protection. Here, we immunized rhesus macaques and assessed immune responses over one year in bloo
Autor:
Patrick J, Madden, Muhammad S, Arif, Mark E, Becker, Michael D, McRaven, Ann M, Carias, Ramon, Lorenzo-Redondo, Sixia, Xiao, Cecily C, Midkiff, Robert V, Blair, Elizabeth Lake, Potter, Laura, Martin-Sancho, Alan, Dodson, Elena, Martinelli, John-Paul M, Todd, Francois J, Villinger, Sumit K, Chanda, Pyone Pyone, Aye, Chad J, Roy, Mario, Roederer, Mark G, Lewis, Ronald S, Veazey, Thomas J, Hope
Publikováno v:
Frontiers in Immunology
Infection with the novel coronavirus, SARS-CoV-2, results in pneumonia and other respiratory symptoms as well as pathologies at diverse anatomical sites. An outstanding question is whether these diverse pathologies are due to replication of the virus
Autor:
Wei Shi, Daniel C. Douek, Kevin W. Bock, Barbara J. Flynn, Juan I. Moliva, Saule T. Nurmukhambetova, Prakriti Mudvari, Laurent Pessaint, Darin K. Edwards, Elizabeth McCarthy, John R. Mascola, Lauren McCormick, Alan Dodson, Jesmine Roberts-Torres, Ian N. Moore, Mahnaz Minai, John-Paul Todd, Swagata Kar, Hanne Leth Andersen, Danielle A. Wagner, Barney S. Graham, Kathryn E. Foulds, Bianca M. Nagata, Anne P. Werner, Cynthia G. Lorang, Adrienne Goode, Eun Sung Yang, Mehul S. Suthar, Lingshu Wang, Bingchun Zhao, Shayne F. Andrew, Martha Nason, Aurélie Ploquin, Meredith E. Davis-Gardner, Eli Boritz, Andrea Carfi, Robert A. Seder, Anthony L. Cook, Matthew Gagne, Nicole A. Doria-Rose, Mario Roederer, Christopher Cole Honeycutt, Nancy J. Sullivan, Farida Laboune, Kizzmekia S. Corbett, Mark G. Lewis, Courtney Tucker, Seyhan Boyoglu-Barnum
Publikováno v:
bioRxiv : the preprint server for biology.
mRNA-1273 vaccine efficacy against SARS-CoV-2 Delta wanes over time; however, there are limited data on the impact of durability of immune responses on protection. We immunized rhesus macaques at weeks 0 and 4 and assessed immune responses over one y
Autor:
Ian N. Moore, Seyhan Boyoglu-Barnum, Swagata Kar, Bianca M. Nagata, Shayne F. Andrew, Joseph R. Francica, John R. Mascola, Shruti N. Shah, Darin K. Edwards, Samantha J. Provost, Barney S. Graham, John Paul Todd, Venkata Viswanadh Edara, Eun Sung Yang, Daniel Valentin, Katelyn Steingrebe, David C. Montefiori, Andrea Carfi, Maciel Porto, Hanne Leth Andersen, Robert A. Seder, Kizzmekia S. Corbett, Wei Shi, Jack Greenhouse, Mark G. Lewis, Evan Lamb, Adrian B. McDermott, Daniel C. Douek, Serge Zouantcha, Kathryn E. Foulds, Nancy J. Sullivan, Mahnaz Minai, Kevin W. Bock, Britta Flach, Lilin Lai, Katharine Floyd, Angela Choi, Charlene McDanal, Jonathan Fintzi, Alan Dodson, Matthew A. Koch, Mario Roederer, Amy T. Noe, Juan I. Moliva, Saule T. Nurmukhambetova, Mitzi M. Donaldson, Laurent Pessaint, Timothy S. Johnston, Andrew Faudree, Anne P. Werner, Mehul S. Suthar, Barbara J. Flynn, Kai Wu, Anthony L. Cook, Sarah O’Connell, Gabriela S. Alvarado, Lingshu Wang, Yi Zhang, Martha Nason, Dillon R. Flebbe, Matthew Gagne, Olubukola M. Abiona, Renee van de Wetering, Kwanyee Leung
Publikováno v:
Science
Immune correlates of protection can be used as surrogate endpoints for vaccine efficacy. The nonhuman primate (NHP) model of SARS-CoV-2 infection replicates key features of human infection and may be used to define immune correlates of protection fol
Autor:
Daniel C. Douek, Rachel L. Davis, Alex Van Ry, Timothy S. Johnston, Stephen D. Schmidt, Adrian B. McDermott, John R. Mascola, Yi Zhang, Anne P. Werner, Lilin Lai, Evan Lamb, Sarah O’ Connell, Kevin W. Bock, John-Paul Todd, Misook Choe, Amy R. Henry, Wei Shi, Alan Dodson, Danielle A. Wagner, Matthew A. Koch, Barney S. Graham, Aurélie Ploquin, Mehul S. Suthar, Farida Laboune, Chaim A. Schramm, Mitzi M. Donaldson, Samantha J. Provost, John Misasi, Christopher Stringham, Bianca M. Nagata, Hanne Leth Andersen, Ian N. Moore, Kizzmekia S. Corbett, Andrea Carfi, Robert A. Seder, Sandeep Narpala, Seyhan Boyoglu-Barnum, Mark G. Lewis, Josue Marquez, Sijy O'Dell, Nancy J. Sullivan, Lingshu Wang, Juan I. Moliva, Saule T. Nurmukhambetova, Courtney Tucker, Zackery Flinchbaugh, Laurent Pessaint, Shayne F. Andrew, Mahnaz Minai, Eli Boritz, Barbara J. Flynn, Andrew Pekosz, Dillon R. Flebbe, Daniel Valentin, Darin K. Edwards, Matthew Gagne, Angela Choi, Manjari Sriparna, Kathryn E. Foulds, Martha Nason, Anthony L. Cook, Gabriela S. Alvarado, Kai Wu, Nicole A. Doria-Rose, Mario Roederer
Publikováno v:
bioRxiv
Neutralizing antibody responses gradually wane after vaccination with mRNA-1273 against several variants of concern (VOC), and additional boost vaccinations may be required to sustain immunity and protection. Here, we evaluated the immune responses i