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Akademický článek

Replacement of dietary carbohydrate with protein increases fat mass and reduces hepatic triglyceride synthesis and content in female obese Zucker rats

Autor: M. Alan Dawson, Stephen R. Hennigar, Mahalakshmi Shankaran, Alyssa M. Kelley, Bradley J. Anderson, Edna Nyangau, Tyler J. Field, William J. Evans, Marc K. Hellerstein, James P. McClung, Stefan M. Pasiakos, Claire E. Berryman

Publikováno v: Physiological Reports, Vol 11, Iss 23, Pp n/a-n/a (2023)

Abstract Previous studies have demonstrated both energy restriction (ER) and higher protein (HP), lower carbohydrate (LC) diets downregulate hepatic de novo lipogenesis. Little is known about the independent and combined impact of ER and HP/LC diets

Externí odkaz: https://doaj.org/article/f37669e2472442d0b80cd04357254140

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BAP1 loss induces mitotic defects in mesothelioma cells through BRCA1-dependent and independent mechanisms

Autor: Andrew Fry, Anita Singh, Sara Busacca, Aarti Gaba, Michael Sheaff, Charlotte Poile, Apostolos Nakas, Joanna Dzialo, Aleksandra Bzura, Alan Dawson, Dean Fennell

Publikováno v: Oncogene. 42:572-585

The tumour suppressor BRCA1-associated protein 1 (BAP1) is the most frequently mutated cancer gene in mesothelioma. Here we report novel functions for BAP1 in mitotic progression highlighting the relationship between BAP1 and control of genome stabil

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::be4aa9725aa09d85a1500efb87441be6
https://doi.org/10.1038/s41388-022-02577-3

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Gene fusions during the early evolution of mesothelioma correlate with impaired DNA repair and Hippo pathways

Autor: Maymun Jama, Min Zhang, Charlotte Poile, Apostolos Nakas, Annabel Sharkey, Joanna Dzialo, Alan Dawson, Kudazyi Kutywayo, Dean A. Fennell, Edward J Hollox

Malignant pleural mesothelioma (MPM), a rare cancer a long latency period (up to 40 years) between asbestos exposure and disease presentation. The mechanisms coupling asbestos to recurrent somatic alterations are poorly defined. Gene-fusions arising

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::7c05e0fd01f3ce6aff0e3f035684fcc4
https://doi.org/10.1101/2023.04.20.23288867

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Metabolic reprogramming provides a novel approach to overcome resistance to BH3-mimetics in Malignant Pleural Mesothelioma

Autor: Xiao-Ming Sun, Gareth J Miles, Ian R Powley, Andrew Craxton, Sarah Galavotti, Tatyana Chernova, Alan Dawson, Apostolos Nakas, Anne E Willis, Kelvin Cain, Marion MacFarlane

Malignant pleural mesothelioma (MPM) is an aggressive malignancy linked to asbestos exposure and highly resistant to chemotherapy, potentially due to upregulated expression of the pro-survival proteins, BCL2/BCL-XL/MCL-1. Using clinically-relevant mo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::98277997b6932d4c9836a4416bc5604c
https://doi.org/10.1101/2023.03.31.534530

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Abstract 6086: Clonal biallelic inactivation of NF2 is an evolutionary bottleneck that exposes a vulnerability to CDK7 inhibition in mesothelioma

Autor: Essa Y. Baitei, Min Zhang, Qianqian Sun, Jin-Li Luo, Philip Zhang, Tamihiro Kamata, James Harber, Aleksandra Bzura, Peter W. Jordan, Charlotte Poile, Alan Dawson, Apostolos Nakas, Cathy Richards, Hongji Yang, Ed Hollox, Dean A. Fennell

Publikováno v: Cancer Research. 82:6086-6086

Background: Mesothelioma, a cancer caused by asbestos is lethal and lacks molecularly targeted therapy. The tumor suppressor NF2 constitutes a frequent, positively selected somatic alteration warranting synthetic lethal approaches to target this driv

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::44dca74d46e86873eb26f17db8fbb51b
https://doi.org/10.1158/1538-7445.am2022-6086

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Abstract 5693: Mesotheliomas harbor early clonal fusions involving both tumor suppressor drivers and novel oncogenic alterations

Autor: Maymun Jama, Edward J Hollox, Apostolos Nakas, Lee Brannan, Alan Dawson, frank dudbridge, Dean Fennell

Publikováno v: Cancer Research. 82:5693-5693

MPM is a pleural tumour associated with asbestos exposure. There is a long latency period of more than 40 years between asbestos exposure and disease presentation, highlighting an unknown evolutionary trajectory. Throughout the latent years, differen

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::1d5116f01fd6d9fc5063788606ca4689
https://doi.org/10.1158/1538-7445.am2022-5693

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Abstract 1613: Systematic screening for genomic vulnerabilities as drug targets for mesothelioma

Publikováno v: Cancer Research. 82:1613-1613

Mesothelioma is a rare, lethal cancer caused by asbestos. Despite recent advances molecularly stratified therapy is lacking, in part due to the challenge of targeting the preponderance of tumor suppressors. Recent efforts to select therapy from our g

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::98927596f10df3e62c11114ed5641ab2
https://doi.org/10.1158/1538-7445.am2022-1613

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Collaboration to Create an IT Bachelor's Degree: Bachelor of Applied Science in Web Design and Development

Autor: Diane Nelson Roux, Scott Alan Dawson

Publikováno v: SIGITE

The creation of this bachelor's degree was a series of innovations for us: a new model for degree creation. This is a bachelor's degree created by a community college. It is a degree program that does not exist anywhere else in the state, and it was

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::91ffcdd7ff1d6faad6aba61785f8530f
https://doi.org/10.1145/3368308.3415373

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