Zobrazeno 1 - 10
of 480
pro vyhledávání: '"Alan Daugherty"'
Autor:
Masayoshi Kukida, Naofumi Amioka, Dien Ye, Hui Chen, Jessica J. Moorleghen, Ching-Ling Liang, Deborah A. Howatt, Yuriko Katsumata, Motoko Yanagita, Hisashi Sawada, Alan Daugherty, Hong S. Lu
Publikováno v:
Frontiers in Cardiovascular Medicine, Vol 10 (2023)
Background and objectiveWhole body manipulation of the renin-angiotensin system (RAS) consistently exerts profound effects on experimental atherosclerosis development. A deficit in the literature has been a lack of attention to the effects of sex. Al
Externí odkaz:
https://doaj.org/article/904dd16b47b94aadadd39e51430c6cc3
Autor:
Jeffrey M. Chalfant, Deborah A. Howatt, Victoria B. Johnson, Lisa R. Tannock, Alan Daugherty, Julie S. Pendergast
Publikováno v:
Frontiers in Physiology, Vol 14 (2023)
Shift work chronically disrupts circadian rhythms and increases the risk of developing cardiovascular disease. However, the mechanisms linking shift work and cardiovascular disease are largely unknown. The goal of this study was to investigate the ef
Externí odkaz:
https://doaj.org/article/55fd1e4ec5f342b6ae656ed535681aca
Autor:
Hisashi Sawada, MD, PhD, Zachary A. Beckner, BS Candidate, Sohei Ito, MD, PhD, Alan Daugherty, PhD, DSc, Hong S. Lu, MD, PhD
Publikováno v:
JVS - Vascular Science, Vol 3, Iss , Pp 64-72 (2022)
The mechanistic basis for the formation of aortic aneurysms and dissection needs to be elucidated to facilitate the development of effective medications. β-Aminopropionitrile administration in mice has been used frequently to study the pathologic fe
Externí odkaz:
https://doaj.org/article/2fa8c548ee814d34914889a2c352832a
Autor:
Shayan Mohammadmoradi, Hisashi Sawada, Sohei Ito, Adam E. Mullick, Deborah A. Howatt, Michael Franklin, Hong S. Lu, Alan Daugherty
Publikováno v:
JVS - Vascular Science, Vol 4, Iss , Pp 100161- (2023)
Externí odkaz:
https://doaj.org/article/f50d2489fcbb441e8cecdffa18fc3285
Autor:
Jackie M. Zhang, Dianaly T. Au, Hisashi Sawada, Michael K. Franklin, Jessica J. Moorleghen, Deborah A. Howatt, Pengjun Wang, Brittany O. Aicher, Brian Hampton, Mary Migliorini, Fenge Ni, Adam E. Mullick, Mashhood M. Wani, Areck A. Ucuzian, Hong S. Lu, Selen C. Muratoglu, Alan Daugherty, Dudley K. Strickland
Publikováno v:
JCI Insight, Vol 8, Iss 2 (2023)
Vascular smooth muscle cells (vSMCs) exert a critical role in sensing and maintaining vascular integrity. These cells abundantly express the low-density lipoprotein receptor–related protein 1 (LRP1), a large endocytic signaling receptor that recogn
Externí odkaz:
https://doaj.org/article/ed0a8984fa804ee7ba6b0ca5af6a4865
Publikováno v:
JVS - Vascular Science, Vol 4, Iss , Pp 100103- (2023)
Externí odkaz:
https://doaj.org/article/0865c322ac9543469a9fdc2914818c3f
Publikováno v:
JVS - Vascular Science, Vol 4, Iss , Pp 100099- (2023)
Externí odkaz:
https://doaj.org/article/41e3a5fbd90d41c786efa78a2bd13063
Autor:
Maura Mobilia, Callie Whitus, Alexander Karakashian, Hong S. Lu, Alan Daugherty, Scott M. Gordon
Publikováno v:
Journal of Lipid Research, Vol 63, Iss 12, Pp 100296- (2022)
Dennd5b plays a pivotal role in intestinal absorption of dietary lipids in mice and is associated with body mass index in humans. This study examined the impact of whole-body Dennd5b deletion on plasma lipid concentrations, atherosclerosis, and hepat
Externí odkaz:
https://doaj.org/article/544f9a5a89e64e989a65c7bb9d00ed19
Autor:
Stephanie Morgan, Lang Ho Lee, Arda Halu, Jessica S. Nicolau, Hideyuki Higashi, Anna H. Ha, Jennifer R. Wen, Alan Daugherty, Peter Libby, Scott J. Cameron, Doran Mix, Elena Aikawa, A. Phillip Owens, Sasha A. Singh, Masanori Aikawa
Publikováno v:
Frontiers in Cardiovascular Medicine, Vol 9 (2022)
BackgroundAbdominal aortic aneurysm (AAA), characterized by a continued expansion of the aorta, leads to rupture if not surgically repaired. Mice aid the study of disease progression and its underlying mechanisms since sequential studies of aneurysm
Externí odkaz:
https://doaj.org/article/4f75d774fba942649f894b3d30b21865
Autor:
Estrellita Uijl, Dien Ye, Liwei Ren, Katrina M. Mirabito Colafella, Richard van Veghel, Ingrid M. Garrelds, Hong S. Lu, Alan Daugherty, Ewout J. Hoorn, Paul Nioi, Don Foster, A. H. Jan Danser
Publikováno v:
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 11, Iss 15 (2022)
Background A single dose of small interfering RNA (siRNA) targeting liver angiotensinogen eliminates hepatic angiotensinogen and lowers blood pressure. Angiotensinogen elimination raises concerns for clinical application because an angiotensin rise i
Externí odkaz:
https://doaj.org/article/1186619f806d410bac10cb41b2836b72