Zobrazeno 1 - 10
of 144
pro vyhledávání: '"Alan D. Phillips"'
Autor:
Camilla Salvestrini, Mark Lucas, Paolo Lionetti, Franco Torrente, Sean James, Alan D Phillips, Simon H Murch
Publikováno v:
PLoS ONE, Vol 9, Iss 9, p e106005 (2014)
We studied the expression of sulphated glycosaminoglycans (GAGs) in coeliac disease (CD) mucosa, as they are critical determinants of tissue volume, which increases in active disease. We also examined mucosal expression of IL-6, which stimulates exce
Externí odkaz:
https://doaj.org/article/ff2704730f1b43a3b056f1c4f04fae32
Publikováno v:
PLoS ONE, Vol 6, Iss 10, p e27030 (2011)
BackgroundEnteropathogenic (EPEC) and Enteroaggregative (EAEC) E. coli have similar, but distinct clinical symptoms and modes of pathogenesis. Nevertheless when they infect the gastrointestinal tract, it is thought that their flagellin causes IL-8 re
Externí odkaz:
https://doaj.org/article/7cb448ced2804feb83ff843adec5927f
Autor:
Hayley J Newton, Jaclyn S Pearson, Luminita Badea, Michelle Kelly, Mark Lucas, Gavan Holloway, Kylie M Wagstaff, Michelle A Dunstone, Joan Sloan, James C Whisstock, James B Kaper, Roy M Robins-Browne, David A Jans, Gad Frankel, Alan D Phillips, Barbara S Coulson, Elizabeth L Hartland
Publikováno v:
PLoS Pathogens, Vol 6, Iss 5, p e1000898 (2010)
Many bacterial pathogens utilize a type III secretion system to deliver multiple effector proteins into host cells. Here we found that the type III effectors, NleE from enteropathogenic E. coli (EPEC) and OspZ from Shigella, blocked translocation of
Externí odkaz:
https://doaj.org/article/db95da39b4bb43fb9bafe6e7de4ba46d
Autor:
Matthias Zilbauer, Andreas Jenke, Gundula Wenzel, Jan Postberg, Andreas Heusch, Alan D Phillips, Gabriele Noble-Jamieson, Franco Torrente, Camilla Salvestrini, Robert Heuschkel, Stefan Wirth
Publikováno v:
PLoS ONE, Vol 5, Iss 10, p e15389 (2010)
BACKGROUND: Human beta-defensins (hBDs) are antimicrobial peptides known to play a major role in intestinal innate host defence. Altered mucosal expression of hBDs has been suggested to be implicated in chronic inflammatory bowel disease pathogenesis
Externí odkaz:
https://doaj.org/article/a761b8a0233444ee9f67fafbf9b21330
Publikováno v:
Cellular Microbiology
Summary Haemolytic uraemic syndrome caused by Shiga toxin-producing E. coli (STEC) is dependent on release of Shiga toxins (Stxs) during intestinal infection and subsequent absorption into the bloodstream. An understanding of Stx-related events in th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::57fd8fe81fe5b77ab16ca0ffa6bbb9fe
https://doi.org/10.1111/cmi.12281
https://doi.org/10.1111/cmi.12281
Publikováno v:
Journal of Experimental & Clinical Medicine. 5:43-50
Human tissue samples are irreplaceable for studying genuine human host responses. Researchers have employed various in vitro and in vivo experimental models to study human intestinal infection. The currently available knowledge concerning enteric pat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::faad62a804e8dda316e3a7fae3d1903f
https://doi.org/10.1016/j.jecm.2013.02.006
https://doi.org/10.1016/j.jecm.2013.02.006
Autor:
Stephen Reece, Christine Hale, Miranda Batchelor, Gad Frankel, Gordon Dougan, Alan D. Phillips, Cameron P. Simmons, Robert J. Fitzhenry, Stephen Matthews
Publikováno v:
Scopus-Elsevier
Intimate bacterial adhesion to intestinal epithelium is a pathogenic mechanism shared by several human and animal enteric pathogens, including enteropathogenic and enterohaemorrhagic Escherichia coli and Citrobacter rodentium. The proteins directly i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::921286486bd59415d7f4176566b1344f
https://ora.ox.ac.uk/objects/uuid:ec067a92-f365-4794-b307-40f0a216282e
https://ora.ox.ac.uk/objects/uuid:ec067a92-f365-4794-b307-40f0a216282e
Autor:
G. Noble-Jamieson, Stefan Wirth, G Wenzel, Andreas Jenke, Alan D. Phillips, D Goedde, Matthias Zilbauer, Camilla Salvestrini, Jan Postberg, Franco Torrente, Robert Heuschkel, Mark Lucas
Publikováno v:
Inflammatory Bowel Diseases. 17:2076-2086
Background: Reduced alpha-defensin expression has been reported in the terminal ileum (TI) of adult patients with ileal Crohn's disease (CD). However, little is known about alpha-defensin expression in children with chronic inflammatory bowel disease
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a82d1c541d7bba0ec80cc8d866596f5b
https://doi.org/10.1002/ibd.21577
https://doi.org/10.1002/ibd.21577
Autor:
Frank M. Ruemmele, Wolf-Dietrich Huber, Andreas Zankl, Walter A. Mihatsch, Silvia Lechner, Peter Heinz-Erian, Ekkehart Lausch, Thomas Müller, Andreas R. Janecke, Alan D. Phillips, Peter Lewindon, Uwe Querfeld
Publikováno v:
Journal of Pediatric Gastroenterology & Nutrition. 53:48-54
Objectives: Autosomal recessive, congenital chloride diarrhea (CLD) is a form of persistent secretory diarrhea, presenting with polyhydramnios and intractable diarrhea from birth. CLD is caused by mutations in the SLC26A3 gene, encoding a Na + -indep
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::74b2ab0952040d5a351b76d0f43cc17b
https://doi.org/10.1097/mpg.0b013e31820bc856
https://doi.org/10.1097/mpg.0b013e31820bc856
Autor:
Alan D. Phillips, Stephanie Schüller
Publikováno v:
Environmental Microbiology. 12:2426-2435
Advances in the understanding of the pathogenesis of enterohaemorrhagic Escherichia coli (EHEC) have greatly benefited from the use of human epithelial cell lines under aerobic conditions. However, in the target site of EHEC infection, the human inte
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d016fcf6c6ff33becfeef1746ca32bee
https://doi.org/10.1111/j.1462-2920.2010.02216.x
https://doi.org/10.1111/j.1462-2920.2010.02216.x