Výsledky vyhledávání - "Alan D. Knapton"

Transforming growth factor beta expression and transformation of rat lung epithelial cells by crystalline silica (quartz)

Autor: Ekwere T. Ifon, Umberto Saffiotti, Alan D. Knapton, A. Olufemi Williams

Publikováno v: International Journal of Cancer. 65:639-649

Crystalline silica (quartz) induces silicosis and associated peripheral lung carcinomas in rats. The role and pattern of expression of transforming growth factor (TGF)-beta1/beta2 mRNA transcripts were investigated in the fetal rat lung epithelial ce

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::87b4f827fec3d83d0afbd0bd9a672285
https://doi.org/10.1002/(sici)1097-0215(19960301)65:5<639::aid-ijc14>3.0.co

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The Liver in Transforming Growth Factor-Beta-1 (TGF-β1) Null Mutant Mice

Autor: A. Olufemi Williams, Andrew G. Geiser, John J. Letterio, Anita B. Roberts, Alan D. Knapton

Publikováno v: Ultrastructural Pathology. 20:477-490

Transforming growth factor-beta-1 (TGF-beta 1) null mutant mice have no gross developmental abnormalities at birth but succumb to multifocal inflammatory lesions that lead to organ failure and death about 20 days after birth. Treatment with anti-infl

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ed7c0f3fb530afd280bab9b7527a3fcd
https://doi.org/10.3109/01913129609016352

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Growth Factors and Gene Expression in Silica-Induced Fibrogenesis and Carcinogenesis

Autor: Umberto Saffiotti, Alan D. Knapton, A. Olufemi Williams

Publikováno v: Applied Occupational and Environmental Hygiene. 10:1089-1098

Transforming growth factor β1 (TGF-β1), ras, and p53 were studied in the rat model for silica-induced fibrogenesis and carcinogenesis, and in the FRLE cell line, derived from fetal rat alveolar pneumocytes. In Fischer-344 rats of both sexes, follow

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::4b625bb9fb69de6d66b7cf171dfdbbe7
https://doi.org/10.1080/1047322x.1995.10389100

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Protective Effects of Silanol Group Binding Agents on Quartz Toxicity to Rat Lung Alveolar Cells

Autor: Lambert N. Daniel, Xianglin Shi, Umberto Saffiotti, Yan Mao, Alan D. Knapton

Publikováno v: Applied Occupational and Environmental Hygiene. 10:1132-1137

In the rat model of fibrosis-associated lung cancer induced by crystalline silica, carcinomas derived from alveolar type II cells are the most common tumor type. To investigate the mechanisms responsible for crystalline silica effects on alveolar epi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::183e381a4e540295af056206893121ef
https://doi.org/10.1080/1047322x.1995.10389107

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Reaction of Cr(VI) with ascorbate and hydrogen peroxide generates hydroxyl radicals and causes DNA damage: role of a Cr(IV)-mediated Fenton-like reaction

Autor: Yan Mao, Xianglin Shi, Peter M. Gannett, Alan D. Knapton, Yongyut Rojanasakul, Min Ding, Kejian Liu, Naresh S. Dalal

Publikováno v: Scopus-Elsevier

Incubation of Cr(VI) with ascorbate generated Cr(V), Cr(IV) and ascorbate-derived carbon-centered alkyl radicals, as well as formyl radicals. H2O2 caused generation of hydroxyl radicals (OH) and much higher levels of Cr(V), showing that .OH can be ge

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ea708b2aec3456b4a1d62fe4464026dc
https://doi.org/10.1093/carcin/15.11.2475

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