Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Alan D. Brailsford"'
Autor:
Alan D. Brailsford, Christopher J. Walker, Nick Wojek, William Chih Wei Chang, David A. Cowan
Publikováno v:
Journal of chromatography. A. 1628
Anabolic androgenic steroids (AAS) have been the most commonly abused substances taken by not only professional sportsmen but also recreational bodybuilders. The detection of micro-dose testosterone (T) misuse is particularly challenging as it posses
Autor:
Martina Palomino-Schätzlein, David A. Cowan, Alan D. Brailsford, Teodor Parella, Cristina Legido-Quigley, Míriam Pérez-Trujillo, Yaoyao Wang
Publikováno v:
Palomino-Schätzlein, M, Wang, Y, Parella, T, Brailsford, A D, Cowan, D A, Legido-Quigley, C & Pérez-Trujillo, M 2017, ' Direct monitoring of Exogenous γ-Hydroxybutyric Acid in body fluids by NMR spectroscopy ', Analytical Chemistry, vol. 89, no. 16, pp. 8343-8350 . https://doi.org/10.1021/acs.analchem.7b01567
γ-Hydroxybutyric acid (GHB) is a popular drug increasingly associated to cases of drug-facilitated sexual assault (DFSA). Currently, expanding procedures of analysis and having forensic evidence of GHB intake at a long term are mandatory. Up to now,
Autor:
Nick Wojek, Alan D. Brailsford, Christopher J. Walker, David A. Cowan, Wan Noor Mahirah Majidin
Publikováno v:
Brailsford, A D, Majidin, W N M, Wojek, N, Cowan, D A & Walker, C 2018, ' IRMS delta values ( 13 C) of nandrolone and testosterone products available in the UK : Implications for anti-doping ', Drug Testing And Analysis, vol. 10, no. 11-12, pp. 1722-1727 . https://doi.org/10.1002/dta.2530
Anabolic androgenic steroids (AAS) are the most widely abused class of drugs by athletes and thus represent a significant problem to the anti-doping community. Confirmation of a doping violation for AAS cannot always be based on their presence alone
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::92f7d607acf193fb68c19947927d21ac
https://kclpure.kcl.ac.uk/ws/files/116913981/IRMS_delta_values_13C_BRAILSFORD_Accepted16October2018Publishedonline31October2018_GREEN_AAM.pdf
https://kclpure.kcl.ac.uk/ws/files/116913981/IRMS_delta_values_13C_BRAILSFORD_Accepted16October2018Publishedonline31October2018_GREEN_AAM.pdf
Autor:
Alan D, Brailsford, Wan Noor Mahirah, Majidin, Nick, Wojek, David A, Cowan, Christopher, Walker
Publikováno v:
Drug testing and analysis. 10(11-12)
Anabolic androgenic steroids (AAS) are the most widely abused class of drugs by athletes and thus represent a significant problem to the anti-doping community. Confirmation of a doping violation for AAS cannot always be based on their presence alone
Autor:
Inge Mick, Gemma Dawe, Claire Durant, Eugenii A. Rabiner, Adam D. Waldman, Roger N. Gunn, Samuel Turton, Jim Myers, David J. Nutt, Anne Lingford-Hughes, Ashwin V. Venkataraman, Alan D. Brailsford, Stafford L. Lightman, Alessandro Colasanti, Mark C. Parkin
Publikováno v:
Molecular psychiatry
Turton, S, Myers, J F, Mick, I, Colasanti, A, Venkataraman, A, Durant, C, Waldman, A, Brailsford, A, Parkin, M C, Dawe, G, Rabiner, E A, Gunn, R N, Lightman, S L, Nutt, D J & Lingford-Hughes, A 2018, ' Blunted endogenous opioid release following an oral dexamphetamine challenge in abstinent alcohol-dependent individuals ', Molecular Psychiatry . https://doi.org/10.1038/s41380-018-0107-4
Turton, S, Myers, J F M, Mick, I, Colasanti, A, Venkataraman, A, Durant, C, Waldman, A, Brailsford, A, Parkin, M C, Dawe, G, Rabiner, E A, Gunn, R N, Lightman, S L, Nutt, D J & Lingford-Hughes, A 2020, ' Blunted endogenous opioid release following an oral dexamphetamine challenge in abstinent alcohol-dependent individuals ', Molecular Psychiatry, pp. 1749-1758. https://doi.org/10.1038/s41380-018-0107-4
Turton, S, Myers, J F, Mick, I, Colasanti, A, Venkataraman, A, Durant, C, Waldman, A, Brailsford, A, Parkin, M C, Dawe, G, Rabiner, E A, Gunn, R N, Lightman, S L, Nutt, D J & Lingford-Hughes, A 2018, ' Blunted endogenous opioid release following an oral dexamphetamine challenge in abstinent alcohol-dependent individuals ', Molecular Psychiatry . https://doi.org/10.1038/s41380-018-0107-4
Turton, S, Myers, J F M, Mick, I, Colasanti, A, Venkataraman, A, Durant, C, Waldman, A, Brailsford, A, Parkin, M C, Dawe, G, Rabiner, E A, Gunn, R N, Lightman, S L, Nutt, D J & Lingford-Hughes, A 2020, ' Blunted endogenous opioid release following an oral dexamphetamine challenge in abstinent alcohol-dependent individuals ', Molecular Psychiatry, pp. 1749-1758. https://doi.org/10.1038/s41380-018-0107-4
Addiction has been proposed as a ‘reward deficient’ state, which is compensated for with substance use. There is growing evidence of dysregulation in the opioid system, which plays a key role in reward, underpinning addiction. Low levels of endog
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8afb125121fda4d6c45199df0c127373
http://hdl.handle.net/10044/1/60048
http://hdl.handle.net/10044/1/60048
Publikováno v:
Analytical chemistry. 90(1)
In response to the letter from Pichini and Busardo, we would like to stress that we do not suggest NMR as an alternative technique to GC-MS or LC-MS, but complementary to them (which could provide additional valuable information), as was stated in th
Autor:
James C. Reynolds, Andrew T. Kicman, David A. Cowan, Alan D. Brailsford, Colin S. Creaser, Matthew A. Turner, Kayleigh L. Arthur
Publikováno v:
Arthur, K L, Turner, M A, Brailsford, A D, Kicman, A T, Cowan, D A, Reynolds, J C & Creaser, C S 2017, ' Rapid analysis of anabolic steroid metabolites in urine by combining field asymmetric waveform ion mobility spectrometry with liquid chromatography and mass spectrometry ', Analytical Chemistry, vol. 89, no. 14, pp. 7431-7437 . https://doi.org/10.1021/acs.analchem.7b00940
The combination of field asymmetric waveform ion mobility spectrometry with liquid chromatography-mass spectrometry (LC-FAIMS-MS) has been developed for the analysis of glucuronide and sulfate metabolites of seven anabolic-androgenic steroids AAS in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aa8971775496b498f4d03b1cbab0c2fa
https://kclpure.kcl.ac.uk/ws/files/71239168/Rapid_analysis_of_anabolic_ARTHUR_Publishedonline14June2017_GREEN_AAM_CC_BY_NC_ND_.pdf
https://kclpure.kcl.ac.uk/ws/files/71239168/Rapid_analysis_of_anabolic_ARTHUR_Publishedonline14June2017_GREEN_AAM_CC_BY_NC_ND_.pdf
Autor:
Alessandro Colasanti, Eugenii A. Rabiner, Alan D. Brailsford, Inge Mick, David J. Nutt, Mark C. Parkin, Anne Lingford-Hughes, Luke Clark, Graham E. Searle, Jim Myers, David Erritzoe, Henrietta Bowden-Jones, Adam D. Waldman, Roger N. Gunn, Paul R. A. Stokes
Publikováno v:
The International Journal of Neuropsychopharmacology. 17:2069-2074
This study aimed to replicate a previous study which showed that endogenous opioid release, following an oral dose of amphetamine, can be detected in the living human brain using [11C]carfentanil positron emission tomography (PET) imaging. Nine healt
Autor:
Mark C. Parkin, Eugenii A. Rabiner, Inge Mick, José Carlos Fernandes Galduróz, Graham E. Searle, Henrietta Bowden-Jones, David Erritzoe, Adam D. Waldman, Alessandro Colasanti, Roger N. Gunn, Paul R. A. Stokes, A. Ramos, Luke Clark, Jim Myers, Alan D. Brailsford, Anne Lingford-Hughes, David J. Nutt
Publikováno v:
Neuropsychopharmacology
Mick, I, Myers, J, Ramos, A C, Stokes, P R A, Erritzoe, D, Colasanti, A, Gunn, R N, Rabiner, E A, Searle, G E, Waldman, A D, Parkin, M C, Brailsford, A D, Galduróz, J C, Bowden-Jones, H, Clark, L, Nutt, D J & Lingford-Hughes, A R 2016, ' Blunted Endogenous Opioid Release Following an Oral Amphetamine Challenge in Pathological Gamblers ', Neuropsychopharmacology, vol. 41, no. 7, pp. 1742–1750 . https://doi.org/10.1038/npp.2015.340
3rd International Conference on Behavioral Addictions
Mick, I, Myers, J, Ramos, A C, Stokes, P R A, Erritzoe, D, Colasanti, A, Gunn, R N, Rabiner, E A, Searle, G E, Waldman, A D, Parkin, M C, Brailsford, A D, Galduróz, J C F, Bowden-jones, H, Clark, L, Nutt, D J & Lingford-hughes, A R 2016, ' Blunted Endogenous Opioid Release Following an Oral Amphetamine Challenge in Pathological Gamblers ', Neuropsychopharmacology, vol. 41, no. 7, pp. 1742-1750 . https://doi.org/10.1038/npp.2015.340
Mick, I, Myers, J, Ramos, A C, Stokes, P R A, Erritzoe, D, Colasanti, A, Gunn, R N, Rabiner, E A, Searle, G E, Waldman, A D, Parkin, M C, Brailsford, A D, Galduróz, J C, Bowden-Jones, H, Clark, L, Nutt, D J & Lingford-Hughes, A R 2016, ' Blunted Endogenous Opioid Release Following an Oral Amphetamine Challenge in Pathological Gamblers ', Neuropsychopharmacology, vol. 41, no. 7, pp. 1742–1750 . https://doi.org/10.1038/npp.2015.340
3rd International Conference on Behavioral Addictions
Mick, I, Myers, J, Ramos, A C, Stokes, P R A, Erritzoe, D, Colasanti, A, Gunn, R N, Rabiner, E A, Searle, G E, Waldman, A D, Parkin, M C, Brailsford, A D, Galduróz, J C F, Bowden-jones, H, Clark, L, Nutt, D J & Lingford-hughes, A R 2016, ' Blunted Endogenous Opioid Release Following an Oral Amphetamine Challenge in Pathological Gamblers ', Neuropsychopharmacology, vol. 41, no. 7, pp. 1742-1750 . https://doi.org/10.1038/npp.2015.340
Pathological gambling is a psychiatric disorder and the first recognized behavioral addiction, with similarities to substance use disorders but without the confounding effects of drug-related brain changes. Pathophysiology within the opioid receptor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::17b660a2eb082ee7c5a09cdd0e7ca980
Publikováno v:
Drug Testing and Analysis. 4:962-969
The accuracy and precision of gas chromatography combustion isotope ratio mass spectrometry (GC-C-IRMS) measurements are highly dependent on analyte purity. Reliable analysis of urinary steroids for doping control therefore requires extensive and tim