Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Alan Cahill"'
Autor:
Rebecca D. Ganetzky, Andrew L. Markhard, Irene Yee, Sheila Clever, Alan Cahill, Hardik Shah, Zenon Grabarek, Tsz-Leung To, Vamsi K. Mootha
Publikováno v:
New England Journal of Medicine. 387:1395-1403
We describe the case of identical twin boys who presented with low body weight despite excessive caloric intake. An evaluation of their fibroblasts showed elevated oxygen consumption and decreased mitochondrial membrane potential. Exome analysis reve
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a4c26f083828cc9628e2b2ea8ac7a75e
https://doi.org/10.1056/nejmoa2202949
https://doi.org/10.1056/nejmoa2202949
Publikováno v:
Molecular Genetics and Metabolism. 135:264-265
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c9d7bf134ffaebca7cf5af012d2ad252
https://doi.org/10.1016/j.ymgme.2022.01.027
https://doi.org/10.1016/j.ymgme.2022.01.027
Publikováno v:
American Journal of Physiology-Gastrointestinal and Liver Physiology. 300:G815-G822
Chronic ethanol feeding is known to negatively impact hepatic energy metabolism. Previous studies have indicated that the underlying lesion responsible for this may lie at the level of the mitoribosome. The aim of this study was to characterize the s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ae0b40604d298dfd28a9c3cd25556346
https://doi.org/10.1152/ajpgi.00108.2010
https://doi.org/10.1152/ajpgi.00108.2010
Autor:
Bernard Fromenty, Adrian Davies, Carol C. Cunningham, Masayuki Adachi, Shannon M. Bailey, Alan Cahill, Hiromasa Ishii
Publikováno v:
Alcoholism: Clinical & Experimental Research. 26:907-915
This article represents the proceedings of a symposium at the 2001 Research Society on Alcoholism meeting in Montreal, Canada. The chairs were Alan Cahill and Carol C. Cunningham. The presentations were (1) Mitochondrial regulation of ethanol-induced
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2ec7f370a77eedc3853c018c89e7a19b
https://doi.org/10.1097/00000374-200206000-00022
https://doi.org/10.1097/00000374-200206000-00022
Autor:
Carol C. Cunningham, Alan Cahill
Publikováno v:
Electrophoresis. 21:3420-3426
Chronic ethanol feeding has been shown to decrease the number of functionally active mitochondrial ribosomes by 55%. In this work, 55S mitochondrial ribosomes were isolated from rat liver and their constitutive proteins characterized by two-dimension
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7cc8f5f0c967060572ca82c7b3e8544e
https://doi.org/10.1002/1522-2683(20001001)21:16<3420::aid-elps3420>3.0.co
https://doi.org/10.1002/1522-2683(20001001)21:16<3420::aid-elps3420>3.0.co
Publikováno v:
Biochemical and Biophysical Research Communications. 265:405-409
Mitochondria isolated from rats chronically fed ethanol were more sensitive to induction of the mitochondrial permeability transition (MPT) by a variety of agents than mitochondria isolated from isocalorically matched controls. The agents utilized ha
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8eabd03b0b62084563a9fbcaaa207cf4
https://doi.org/10.1006/bbrc.1999.1696
https://doi.org/10.1006/bbrc.1999.1696
Publikováno v:
Analytical Biochemistry. 232:47-55
A procedure has been developed that allows characterization of mitochondrial ribosomes and quantitative analysis of the relative composition of constitutive ribosomal proteins. Purified mitochondrial ribosomes were isolated from two rat livers and sh
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ca1a066c9c88fb86e8706b93ace06cdd
https://doi.org/10.1006/abio.1995.9962
https://doi.org/10.1006/abio.1995.9962
Publikováno v:
Biochemical Pharmacology. 45:321-329
Purified DT-diaphorase [NAD(P)H (quinone acceptor) oxidoreductase (EC.1.6.99.2)] from Walker cells was used to investigate the reductive metabolism of 3-amino-1,2,4-benzotriazine-1,4-dioxide (SR 4233) under aerobic and anaerobic conditions. In the pr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6c7ee16d252abf266901451a39046150
https://doi.org/10.1016/0006-2952(93)90067-7
https://doi.org/10.1016/0006-2952(93)90067-7
Publikováno v:
Alcoholism, clinical and experimental research. 33(1)
Background—Chronic ethanol feeding to male rats has been shown to result in decreased mitochondrial translation, depressed respiratory complex levels and mitochondrial respiration rates. In addition, ethanol consumption has been shown to result in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8ac4f4e6cf65c3d82b1fef580188cbae
https://pubmed.ncbi.nlm.nih.gov/18828798
https://pubmed.ncbi.nlm.nih.gov/18828798
Autor:
Alan Cahill, Peter Sykora
Publikováno v:
Alcohol ISBN: 9781588299062
Chronic alcohol consumption has been shown to severely compromise mitochondrial protein synthesis. Hepatic mitochondria isolated from alcoholic animals contain decreased levels of respiratory complexes and display depressed respiration rates when com
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f2d3bf5164ded702112ecb073f95bd68
https://pubmed.ncbi.nlm.nih.gov/18369931
https://pubmed.ncbi.nlm.nih.gov/18369931