Zobrazeno 1 - 10
of 145
pro vyhledávání: '"Alan C Foster"'
Autor:
Stephanie Szobota, Pranav D Mathur, Sairey Siegel, KristenAnn Black, H Uri Saragovi, Alan C Foster
Publikováno v:
PLoS ONE, Vol 14, Iss 10, p e0224022 (2019)
Neurotrophins and their mimetics are potential treatments for hearing disorders because of their trophic effects on spiral ganglion neurons (SGNs) whose connections to hair cells may be compromised in many forms of hearing loss. Studies in noise or o
Externí odkaz:
https://doaj.org/article/0e9581df75904907b9947384eccca688
Autor:
Alan C Foster, Jill Farnsworth, Genevieve E Lind, Yong-Xin Li, Jia-Ying Yang, Van Dang, Mahmud Penjwini, Veena Viswanath, Ursula Staubli, Michael P Kavanaugh
Publikováno v:
PLoS ONE, Vol 11, Iss 6, p e0156551 (2016)
N-methyl-D-aspartate (NMDA) receptors play critical roles in synaptic transmission and plasticity. Activation of NMDA receptors by synaptically released L-glutamate also requires occupancy of co-agonist binding sites in the tetrameric receptor by eit
Externí odkaz:
https://doaj.org/article/0fc9a259394b49028075712dc587e026
Autor:
Sairey Siegel, Stephanie Szobota, Alan C. Foster, Alba Galan, Marinko V. Sarunic, Fouad Brahimi, H. Uri Saragovi
Publikováno v:
Molecular Pharmacology. 100:491-501
The neurotrophin growth factors bind and activate two types of cell surface receptors: the tropomyosin receptor kinase (Trk) family and p75. TrkA, TrkB, and TrkC are bound preferentially by nerve growth factor, brain-derived neurotrophic factor, and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dcbfba2523444945ec58acf9448bd81b
https://doi.org/10.1124/molpharm.121.000301
https://doi.org/10.1124/molpharm.121.000301
Autor:
Alan C. Foster, Stephanie Szobota, Fabrice Piu, Bonnie E. Jacques, David R. Moore, Victoria A. Sanchez, Jeffery J. Anderson
Publikováno v:
The Journal of the Acoustical Society of America. 151(6)
Currently, there are no approved medicines available for the treatment of hearing loss. However, research over the past two decades has contributed to a growing understanding of the pathological mechanisms in the cochlea that result in hearing diffic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::38adb87d1b7bb082f6d7233567e119e5
https://pubmed.ncbi.nlm.nih.gov/35778165
https://pubmed.ncbi.nlm.nih.gov/35778165
Publikováno v:
Pharmacology researchperspectives. 10(3)
Despite a prevalence greater than cancer or diabetes, there are no currently approved drugs for the treatment of hearing loss. Research over the past two decades has led to a vastly improved understanding of the cellular and molecular mechanisms in t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2b83bf93c223619860159f9d2b3d9f85
https://pubmed.ncbi.nlm.nih.gov/35599339
https://pubmed.ncbi.nlm.nih.gov/35599339
Autor:
Ashutosh A. Kulkarni, Alan C. Foster, Grigor Abelian, Jia-Ying Yang, Miguel Alcantara, Yong-Xin Li, Ursula Staubli
Publikováno v:
Journal of Pharmacology and Experimental Therapeutics. 367:292-301
The N-methyl-d-aspartate receptor coagonist d-serine is a substrate for the neutral amino acid transporters ASCT1 and ASCT2, which may regulate its extracellular levels in the central nervous system (CNS). We tested inhibitors of ASCT1 and ASCT2 for
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3899c2759a8735e812d9a3e8def4afd9
https://doi.org/10.1124/jpet.118.251116
https://doi.org/10.1124/jpet.118.251116
Autor:
June Chen, Yong-Xin Li, Apurba Datta, Srinath Pashikanti, George R. Ehring, Steven Venadas, Stephen A. Runyan, Ursula Staubli, Tim Dinh, Alan C. Foster
Publikováno v:
Journal of Neurochemistry. 136:692-697
The enantiomers of erythro-3-hydroxyaspartate were tested for activity at glutamate transporters and NMDA receptors. Both enantiomers inhibited glutamate transporters in rat hippocampal crude synaptosomes and elicited substrate-like activity at excit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5e2a14f792b4310e39c32efbc3fd4b70
https://doi.org/10.1111/jnc.13430
https://doi.org/10.1111/jnc.13430
Autor:
Stephen A. Runyan, Steven Venadas, Yong-Xin Li, June Chen, Tim Dinh, Alan C. Foster, Ursula Staubli, George R. Ehring
Publikováno v:
Neuropharmacology. 97:436-446
Understanding the storage and release of the excitatory neurotransmitter, l -glutamate by synaptic vesicles has lagged behind receptor characterizations due to a lack of pharmacological agents. We report that the glutamate analog, 3-aminoglutarate (3
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b157948851f3bc78daaa5ea31dbbd382
https://doi.org/10.1016/j.neuropharm.2015.05.010
https://doi.org/10.1016/j.neuropharm.2015.05.010
Autor:
Xia Wu, Xin Tang, Gong Chen, Chicheng Sun, Yong-Xin Li, Zheng Wu, Alan C. Foster, Ursula Staubli
Publikováno v:
Neuropharmacology. 97:95-103
Pharmacological tools that interact with the mechanisms that regulate vesicular filling and release of the neurotransmitter L-glutamate would be of enormous value. In this study, we provide physiological evidence that the glutamate analog, 3-aminoglu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a15bd0257d4c16d28ca7ead1df56ce73
https://doi.org/10.1016/j.neuropharm.2015.05.011
https://doi.org/10.1016/j.neuropharm.2015.05.011
Autor:
Mahmud Penjwini, Natalie Rangel-Diaz, Yong-Xin Li, Jia-Ying Yang, Alan C. Foster, Veena Viswanath, Ursula Staubli
Publikováno v:
Neuropharmacology. 126
The N-methyl-d-aspartate receptor (NMDA) co-agonist d-serine is a substrate for the neutral amino acid transporters ASCT1 (SLC1A4) and ASCT2 (SLC1A5). We identified l-phenylglycine (PG) and its analogs as inhibitors of ASCT1 and ASCT2. PG analogs wer
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5c5c27bed4f700c7cbfbd36ae821d07d
https://pubmed.ncbi.nlm.nih.gov/28807674
https://pubmed.ncbi.nlm.nih.gov/28807674