Zobrazeno 1 - 10
of 70
pro vyhledávání: '"Alan Buckler"'
Autor:
Ralph Tiedt, Alan Buckler, Christopher J. Wilson, Diana Graus-Porta, Vic E. Myer, Jeffrey A. Porter, William R. Sellers, Francesco Hofmann, Peter M. Finan, Thomas Metz, Vito Guagnano, Chris X. Lu, Feng He, Yao Yao, Christian Chatenay-Rivauday, Andreas Buness, Christelle Stamm, Sabrina Wagner, Kelly Ann Sheppard, Lijuan Liu, Douglas Jeffery, Sneha Sanghavi, Vanessa J. Craig, Fred Harbinski
PDF file - 75K, This file contains detailed descriptions of materials and methods that had to be omitted from the main manuscript due to space limitations
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::54c98b6b1a6e0d1506dc7ac17ab9bf49
https://doi.org/10.1158/2159-8290.22528515.v1
https://doi.org/10.1158/2159-8290.22528515.v1
Autor:
Ralph Tiedt, Alan Buckler, Christopher J. Wilson, Diana Graus-Porta, Vic E. Myer, Jeffrey A. Porter, William R. Sellers, Francesco Hofmann, Peter M. Finan, Thomas Metz, Vito Guagnano, Chris X. Lu, Feng He, Yao Yao, Christian Chatenay-Rivauday, Andreas Buness, Christelle Stamm, Sabrina Wagner, Kelly Ann Sheppard, Lijuan Liu, Douglas Jeffery, Sneha Sanghavi, Vanessa J. Craig, Fred Harbinski
PDF file - 59K, This file contains additional experimental data relating to the profile of JAA120, secretome screening results, gene expression data, and in vivo MET/FGR inhibitor synergy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8822d966da43dd533bf0e796b84a95c8
https://doi.org/10.1158/2159-8290.22528509
https://doi.org/10.1158/2159-8290.22528509
Autor:
Ralph Tiedt, Alan Buckler, Christopher J. Wilson, Diana Graus-Porta, Vic E. Myer, Jeffrey A. Porter, William R. Sellers, Francesco Hofmann, Peter M. Finan, Thomas Metz, Vito Guagnano, Chris X. Lu, Feng He, Yao Yao, Christian Chatenay-Rivauday, Andreas Buness, Christelle Stamm, Sabrina Wagner, Kelly Ann Sheppard, Lijuan Liu, Douglas Jeffery, Sneha Sanghavi, Vanessa J. Craig, Fred Harbinski
PDF file - 310K, This file contains additional experimental data relating to ligand-mediated rescue and drug combinations in cancer cell lines
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6056ab23a9ee72d9ae3c3a8094ae846e
https://doi.org/10.1158/2159-8290.22528518
https://doi.org/10.1158/2159-8290.22528518
Autor:
Ralph Tiedt, Alan Buckler, Christopher J. Wilson, Diana Graus-Porta, Vic E. Myer, Jeffrey A. Porter, William R. Sellers, Francesco Hofmann, Peter M. Finan, Thomas Metz, Vito Guagnano, Chris X. Lu, Feng He, Yao Yao, Christian Chatenay-Rivauday, Andreas Buness, Christelle Stamm, Sabrina Wagner, Kelly Ann Sheppard, Lijuan Liu, Douglas Jeffery, Sneha Sanghavi, Vanessa J. Craig, Fred Harbinski
XLS file - 147K, Expression of selected RTKs and cognate ligands in cancer cell lines as a basis for selecting models for testing of FGFR/MET inhibitor combinations
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::356e72ceed31e9513e886aea92daa0c2
https://doi.org/10.1158/2159-8290.22528512
https://doi.org/10.1158/2159-8290.22528512
Autor:
Nicole Danek, Ashish Kalra, Stefan Wawersik, Ryan R. Faucette, Gregory J. Carven, Constance Martin, Alan Buckler, Anastasia Nikiforov, Frederick C. Streich, Christopher Brueckner, Pichai Raman, Lin Susan, Kevin B. Dagbay, Christopher Littlefield, Justin W. Jackson, Christopher Chapron, Francis T. Danehy, Thomas Schurpf, Christopher Boston, Allison Simpson, Abhishek Datta, Capili Allan
Publikováno v:
Science Translational Medicine. 12
Despite breakthroughs achieved with cancer checkpoint blockade therapy (CBT), many patients do not respond to anti-programmed cell death-1 (PD-1) due to primary or acquired resistance. Human tumor profiling and preclinical studies in tumor models hav
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::45bb38815c8f0b5ea7b3054e6a547d6d
https://doi.org/10.1126/scitranslmed.aay8456
https://doi.org/10.1126/scitranslmed.aay8456
Autor:
Karen S. Chen, Kelly Howell, Shaun M. Cote, Karen M. O'Shea, Joseph P. Stains, Sergey Paushkin, Adriana Donovan, Erin Renae Treece, Ramzi J. Khairallah, Alan Buckler, Long Kimberly, Micah T. Webster
Publikováno v:
Human Molecular Genetics
Spinal muscular atrophy (SMA) is a neuromuscular disease characterized by loss of α-motor neurons, leading to profound skeletal muscle atrophy. Patients also suffer from decreased bone mineral density and increased fracture risk. The majority of tre
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::51cb72607daaa23f3b08baf0aeb28245
https://doi.org/10.1093/hmg/ddy382
https://doi.org/10.1093/hmg/ddy382
Autor:
Erik C. Hett, Michelle L. Ols, Kejie Li, Elisabeth Vollman, Tricia L. May-Dracka, Tracy J. Jenkins, Paramasivam Murugan, Weike Zeng, Jun Feng, Kate L. Henry, Capacci Andrew George, Andrea Bertolotti-Ciarlet, Ellen Cahir-McFarland, Brian Lucas, Christine Loh, Alan Buckler, Thomas Cameron, Peter Juhasz, Brian T. Hopkins, Katelin A. Ennis, John E. Anderson, Mercedes Beyna, Benbo Gao, Debra Kellner, Norm Allaire, Govinda Bhisetti, Ru Wei, Bekim Bajrami
Publikováno v:
Science signaling. 11(541)
Members of the family of nuclear factor κB (NF-κB) transcription factors are critical for multiple cellular processes, including regulating innate and adaptive immune responses, cell proliferation, and cell survival. Canonical NF-κB complexes are
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1603d9db2d7188ad3679c07e1fefd2ec
https://pubmed.ncbi.nlm.nih.gov/30065029
https://pubmed.ncbi.nlm.nih.gov/30065029
Autor:
Amin Kamel, Elizabeth George, Xiaolin Gao, Antonin V. Tutter, Diksha Bhatia, Vic E. Myer, Mark Labow, Irina Alimov, Panagiotis Hatsis, Alan Buckler, Louis Wang, Mithat Gunduz, Christine D. Wilson, Earl Mcdonald, Gregory A. Michaud, Yucheng Ni, Kavitha Venkatesan, Jeffrey A. Porter, Yan Feng, Shaowen Wang, Deborah Rothman, Timothy Rasmusson, Mary Ellen Digan, David Farley, John A. Tallarico, Fred Harbinski
Publikováno v:
Chemistry & Biology. 22:1228-1237
SummaryIn an attempt to identify novel therapeutics and mechanisms to differentially kill tumor cells using phenotypic screening, we identified N-benzyl indole carbinols (N-BICs), synthetic analogs of the natural product indole-3-carbinol (I3C). To u
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f299b5d21cce111f5872a6c80b374946
https://doi.org/10.1016/j.chembiol.2015.06.025
https://doi.org/10.1016/j.chembiol.2015.06.025
Autor:
M. Rutter, Diane Lucente, Colette Rossier, Stylianos E. Antonarakis, Roman Chrast, Mary Kay McCormick, Sonia Samec, Alan Buckler, Haiming Chen, D.K. Shea
Publikováno v:
Karolinska Institutet
Human Molecular Genetics, Vol. 4, No 8 (1995) pp. 1305-1311
Scopus-Elsevier
Human Molecular Genetics, Vol. 4, No 8 (1995) pp. 1305-1311
Scopus-Elsevier
Exon amplification has been applied to a 2.5 Mb region of chromosome 21 that has been associated with some features of Down syndrome (DS). Identification of the majority of genes from this region will facilitate the correlation of the over-expression
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d26f94991c2a5c444efba9237d81833c
http://doc.rero.ch/record/300824/files/4-8-1305.pdf
http://doc.rero.ch/record/300824/files/4-8-1305.pdf
Autor:
Jeremy L. Jenkins, Savina Jaeger, Florian Nigsch, Alan Buckler, Janna Hutz, Stephen Cleaver, Miguel Luiz Camargo, Junxia Min, Allen Cornett
Publikováno v:
SLAS Discovery. 19:791-802
Gene-expression data are often used to infer pathways regulating transcriptional responses. For example, differentially expressed genes (DEGs) induced by compound treatment can help characterize hits from phenotypic screens, either by correlation wit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::daf135e95dee56b943b22a0a4b095193
https://doi.org/10.1177/1087057114522690
https://doi.org/10.1177/1087057114522690