Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Alan Blakely"'
Autor:
Yongxiang Zhao, Heidi Schubert, Alan Blakely, Biff Forbush, Micholas Dean Smith, Jesse Rinehart, Erhu Cao
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-13 (2024)
Abstract The Na+-Cl− cotransporter (NCC) drives salt reabsorption in the kidney and plays a decisive role in balancing electrolytes and blood pressure. Thiazide and thiazide-like diuretics inhibit NCC-mediated renal salt retention and have been cor
Externí odkaz:
https://doaj.org/article/87a930fb5d4d47b4a92446a3cdb26fec
Autor:
J. Michael McIntosh, Alan Blakely, Cheryl Dowell, Danny Hung-Chieh Chou, Nan Zheng, Landa Purushottam, Sean Christensen
Publikováno v:
J Med Chem
Non-opioid therapeutics for the treatment of neuropathic pain are urgently needed to address the ongoing opioid crisis. Peptides from cone snail venoms have served as invaluable molecules to target key pain-related receptors but can suffer from unfav
Autor:
Michael C. Lawrence, Carlie Delaine, Heidi L. Schubert, Allanah Merriman, Xiaochun Xiong, Ünal Coskun, Theresia Gutmann, Briony E. Forbes, Rahul Agrawal, Helena Safavi-Hemami, Alan Blakely, John G. Menting, Jin Hwan Kim, Christopher P. Hill, Gizem Artik, Yi Zhang, Simon J. Fisher, Danny Hung-Chieh Chou, Ingmar B. Schäfer
Cone snail venoms contain a wide variety of bioactive peptides, including insulin-like molecules with distinct structural features, binding modes, and biochemical properties. Here, we report a fully active humanized cone snail venom insulin with an e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6f22807bbb2352e33e6651bd89c5b6d0
https://doi.org/10.21203/rs.3.rs-501661/v1
https://doi.org/10.21203/rs.3.rs-501661/v1
Autor:
Xiaochun Xiong, Alan Blakely, Jin Hwan Kim, John G. Menting, Ingmar B. Schäfer, Heidi L. Schubert, Rahul Agrawal, Theresia Gutmann, Carlie Delaine, Yi Wolf Zhang, Gizem Olay Artik, Allanah Merriman, Debbie Eckert, Michael C. Lawrence, Ünal Coskun, Simon J. Fisher, Briony E. Forbes, Helena Safavi-Hemami, Christopher P. Hill, Danny Hung-Chieh Chou
Publikováno v:
Nat. Chem. Biol. 18, 511-519 (2022)
Cone snail venoms contain a wide variety of bioactive peptides, including insulin-like molecules with distinct structural features, binding modes and biochemical properties. Here, we report an active humanized cone snail venom insulin with an elongat
Autor:
Yi Wolf Zhang, Prasoona Karra, William L. Holland, Alan Blakely, Christopher P. Hill, Danny Hung-Chieh Chou, Matthew J. Webber, Gabrielle Ghabash, Michael A. VandenBerg, Xiaochun Xiong, Frank G. Whitby
Publikováno v:
Chemical Science
A novel four-disulfide insulin analog was designed with retained bioactivity and increased fibrillation stability.
Although insulin was first purified and used therapeutically almost a century ago, there is still a need to improve therapeutic ef
Although insulin was first purified and used therapeutically almost a century ago, there is still a need to improve therapeutic ef
Autor:
Joel A. Kooren, Pratik D. Jagtap, James E. Johnson, Alan Blakely, Kevin Murray, Joel D. Rudney, Nelson L. Rhodus, Shaun Stewart, Timothy J. Griffin
Publikováno v:
Proteomics. 15(20)
Metaproteomics characterizes proteins expressed by microorganism communities (microbiome) present in environmental samples or a host organism (e.g. human), revealing insights into the molecular functions conferred by these communities. Compared to co