Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Alan Basset"'
Autor:
Alan Basset, Emma Wall, Elena Mitsi, Chloe Deshusses, Raecliffe Daly, Sherin Pojar, Jesús Reiné, Jose Afonso Guerra-Assuncao, Brigitte Denis, Simon P. Jochems, Robert Heyderman, Jeremy Brown, Ying-Jie Lu, Daniela M. Ferreira, Richard Malley
Publikováno v:
Infection and Immunity, 90(7). AMER SOC MICROBIOLOGY
Infect Immun
Infect Immun
The advent of pneumococcal conjugate vaccines led to the near disappearance of most of the included serotypes in high-income settings but also the rise of nonvaccine-type colonization and disease. Alternative strategies, using genetically conserved p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5547926577aaeccddbc44ebcf7e8a4a1
https://hdl.handle.net/1887/3567055
https://hdl.handle.net/1887/3567055
Autor:
Sherin Pojar, Elissavet Nikolaou, Elena Mitsi, Carla Solórzano, Alan Basset, Andrew Camilli, Caz Hales, Angela D. Hyder-Wright, Tao Chen, Victoria Connor, Jenna F. Gritzfeld, Jamie Rylance, Stuart C. Clarke, Esther L. German, Richard Malley, David W. Cleary, Marien I. de Jonge, Jeffrey N. Weiser, Saskia van Selm, Ankur B. Dalia, Helen Hill, Rebecca A. Gladstone, Marc J. Eleveld, Daniela M. Ferreira, Andrea M. Collins, Simon P. Jochems, Stephen D. Bentley, Stephen B. Gordon
SummaryColonization efficiency varies considerably between Streptococcus pneumoniae (pneumococcus) strains. The microbial characteristics that influence those differences are still largely unknown. Here, we report rates and kinetics of colonization o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4c1bf1415a77af4aec56be18cda7eed1
Autor:
Elaine Cheung, Richard Malley, Kristin Moffitt, Alan Basset, S. Martin, Muriel Herd, Angela Howard
Publikováno v:
Clinical and Vaccine Immunology. 22:909-916
A pneumococcal whole-cell vaccine (WCV) confers T H 17-mediated immunogenicity and reduces nasopharyngeal (NP) carriage in mice. Activation of Toll-like receptor 2 (TLR2) has been shown to be important for generating T H 17 responses, and several lip
Publikováno v:
Journal of bacteriology. 199(15)
In Streptococcus pneumoniae , the type 1 pilus is involved in many steps of pathogenesis, including adherence to epithelial cells, mediation of inflammation, escape from macrophages, and the formation of biofilms. The type 1 pilus genes are expressed
Autor:
Richard Malley, Alan Basset, Andrew Camilli, Cyril H. Benes, Claudette M. Thompson, Fan Zhang, Douglas T. Golenbock, Sabina Sayeed, Muriel Herd
Publikováno v:
The Journal of biological chemistry. 288(4)
The pneumococcal type 1 pilus is an inflammatory and adherence-promoting structure associated with increased virulence in mouse models. We show that RrgA, an ancillary pilus subunit devoid of a lipidation motif, particularly when presented as part of
The pneumococcal type 1 pilus, which is present in 25 to 30% of clinical isolates, has been associated with increased adherence and inflammatory responses and is being evaluated as a potential vaccine candidate. Here we show that expression of the pi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8bcf74170581617e40353db19cee2175
https://europepmc.org/articles/PMC3147576/
https://europepmc.org/articles/PMC3147576/
Autor:
Alan Basset, Ethan Rubinstein, Gili Regev-Yochay, Ron Dagan, Marc Lipsitch, Meir Raz, Richard Malley
Publikováno v:
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America. 48(6)
The determinants of the negative association between Streptococcus pneumoniae and Stapylococcus aureus colonization are unknown. In this matched case-control study, the odds of co-colonization with S. aureus were significantly lower for individuals c
Autor:
Amit Kumar Srivastava, Alan Basset, Claudette M. Thompson, Marc Lipsitch, Richard Malley, Krzysztof Trzciński
CD4+T-cell-dependent acquired immunity confers antibody-independent protection against pneumococcal colonization. Since this mechanism is poorly understood for extracellular bacteria, we assessed the antigen specificity of the induction and recall of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::31c5dde103f1f791b96345303df89e9b
https://europepmc.org/articles/PMC2423086/
https://europepmc.org/articles/PMC2423086/
Autor:
Claudette M. Thompson, Richard Malley, Alan Basset, Susan K. Hollingshead, Marc Lipsitch, Edwin W. Ades, David E. Briles
Publikováno v:
Infection and immunity. 75(11)
Immunity to pneumococcal colonization in mice by exposure to live or killed pneumococci has been shown to be antibody independent but dependent on CD4 + T cells. Here we show that intranasal immunization with pneumococcal proteins (pneumococcal surfa