Výsledky vyhledávání - "Alan B. Zong"

Akademický článek

Graded effects of unregulated smooth muscle myosin on intestinal architecture, intestinal motility and vascular function in zebrafish

Autor: Joshua Abrams, Zev Einhorn, Christoph Seiler, Alan B. Zong, H. Lee Sweeney, Michael Pack

Publikováno v: Disease Models & Mechanisms, Vol 9, Iss 5, Pp 529-540 (2016)

Smooth muscle contraction is controlled by the regulated activity of the myosin heavy chain ATPase (Myh11). Myh11 mutations have diverse effects in the cardiovascular, digestive and genitourinary systems in humans and animal models. We previously rep

Externí odkaz: https://doaj.org/article/9b7c175f66f84206b6705f95b8a65876

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Role of Insert-1 of Myosin VI in Modulating Nucleotide Affinity

Autor: Lin Song, H. Lee Sweeney, Xiaoyan Liu, Anne Houdusse, Olena Pylypenko, Gaelle Squires, Alan B. Zong

Publikováno v: Journal of Biological Chemistry
Journal of Biological Chemistry, American Society for Biochemistry and Molecular Biology, 2011, 286 (13), pp.11716-11723. ⟨10.1074/jbc.m110.200626⟩
Journal of Biological Chemistry, American Society for Biochemistry and Molecular Biology, 2011, 286 (13), pp.11716-11723. ⟨10.1074/jbc.M110.200626⟩

International audience; Myosin VI is unique in its directionality among myosin superfamily members and also displays a slow and strain-dependent rate of ATP binding that allows for gating between its heads. In this study we demonstrate that leucine 3

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c84ddc4514cb2274ddd3e2035ba68cb7
https://doi.org/10.1074/jbc.m110.200626

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Graded effects of unregulated smooth muscle myosin on intestinal architecture, intestinal motility and vascular function in zebrafish

Autor: Michael Pack, Alan B. Zong, Zev Einhorn, Christoph Seiler, Joshua Abrams, H. Lee Sweeney

Publikováno v: Disease Models & Mechanisms
Disease Models & Mechanisms, Vol 9, Iss 5, Pp 529-540 (2016)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dc7da83ca37f6dd470bfc2cb6259ca4f
https://pubmed.ncbi.nlm.nih.gov/26893369

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Cargo binding induces dimerization of myosin VI

Autor: Alan B. Zong, Denis Phichith, Daniel Safer, Zhaohui Yang, Mirko Travaglia, Xiaoyan Liu, H. Lee Sweeney

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America. 106(41)

Although myosin VI has properties that would allow it to function optimally as a dimer, full-length myosin VI exists as a monomer in isolation. Based on the ability of myosin VI monomers to dimerize when held in close proximity, we postulated that ca

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e4fe6ddab0ead6f9e50d5c5696c09da1
https://pubmed.ncbi.nlm.nih.gov/19805065

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How myosin VI coordinates its heads during processive movement

Autor: Steven S. Rosenfeld, H. Lee Sweeney, Paul R. Selvin, Alan B. Zong, Hyokeun Park, Zhaohui Yang

Publikováno v: The EMBO journal. 26(11)

A processive molecular motor must coordinate the enzymatic state of its two catalytic domains in order to prevent premature detachment from its track. For myosin V, internal strain produced when both heads of are attached to an actin track prevents c

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6e80a22c3bd0217af71ce87ad1a4f375
https://pubmed.ncbi.nlm.nih.gov/17510632

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