Zobrazeno 1 - 10
of 63
pro vyhledávání: '"Alan B. Sachs"'
Autor:
Marija Tadin-Strapps, Laurence B. Peterson, Anne-Marie Cumiskey, Raymond L. Rosa, Vivienne Halili Mendoza, Jose Castro-Perez, Oscar Puig, Liwen Zhang, Walter R. Strapps, Satyasri Yendluri, Lori Andrews, Victoria Pickering, Julie Rice, Lily Luo, Zhu Chen, Samnang Tep, Brandon Ason, Elizabeth Polizzi Somers, Alan B. Sachs, Steven R. Bartz, Jenny Tian, Jayne Chin, Brian K. Hubbard, Kenny K. Wong, Lyndon J. Mitnaul
Publikováno v:
Journal of Lipid Research, Vol 52, Iss 6, Pp 1084-1097 (2011)
Increased serum apolipoprotein (apo)B and associated LDL levels are well-correlated with an increased risk of coronary disease. ApoE–/– and low density lipoprotein receptor (LDLr)–/– mice have been extensively used for studies of coronary ath
Externí odkaz:
https://doaj.org/article/0b029968df064a1196d6bf73ea9f6a26
Autor:
Brandon Ason, Samnang Tep, Jr. Harry R. Davis, Yiming Xu, Glen Tetzloff, Beverly Galinski, Ferdie Soriano, Natalya Dubinina, Lei Zhu, Alice Stefanni, Kenny K. Wong, Marija Tadin-Strapps, Steven R. Bartz, Brian Hubbard, Mollie Ranalletta, Alan B. Sachs, W. Michael Flanagan, Alison Strack, Nelly A. Kuklin
Publikováno v:
Journal of Lipid Research, Vol 52, Iss 4, Pp 679-687 (2011)
Reducing circulating LDL-cholesterol (LDL-c) reduces the risk of cardiovascular disease in people with hypercholesterolemia. Current approaches to reduce circulating LDL-c include statins, which inhibit cholesterol synthesis, and ezetimibe, which blo
Externí odkaz:
https://doaj.org/article/5914edaf91c54338b6cfc9ad1842ba30
Autor:
Ronald C Hendrickson, Anita Y H Lee, Qinghua Song, Andy Liaw, Matt Wiener, Cloud P Paweletz, Jeffrey L Seeburger, Jenny Li, Fanyu Meng, Ekaterina G Deyanova, Matthew T Mazur, Robert E Settlage, Xuemei Zhao, Katie Southwick, Yi Du, Dan Holder, Jeffrey R Sachs, Omar F Laterza, Aimee Dallob, Derek L Chappell, Karen Snyder, Vijay Modur, Elizabeth King, Catharine Joachim, Andrey Y Bondarenko, Mark Shearman, Keith A Soper, A David Smith, William Z Potter, Ken S Koblan, Alan B Sachs, Nathan A Yates
Publikováno v:
PLoS ONE, Vol 10, Iss 8, p e0135365 (2015)
Disease modifying treatments for Alzheimer's disease (AD) constitute a major goal in medicine. Current trends suggest that biomarkers reflective of AD neuropathology and modifiable by treatment would provide supportive evidence for disease modificati
Externí odkaz:
https://doaj.org/article/9acb46913f794a2a8b1b2a7a679cc6a4
Autor:
W. Michael Flanagan, Samnang Tep, Brian K. Hubbard, Alice C. Stefanni, Thomas P. Roddy, Alan B. Sachs, Thomas Hankemeier, Brandon Ason, Nelly A. Kuklin, Jose Castro-Perez, Lyndon J. Mitnaul, Marija Tadin-Strapps
Publikováno v:
Lipids
The association between hypercholesterolemia and elevated serum apolipoprotein B (APOB) has generated interest in APOB as a therapeutic target for patients at risk of developing cardiovascular disease. In the clinic, mipomersen, an antisense oligonuc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::850c92266b9066fdb9d796c5e8952440
https://doi.org/10.1007/s11745-011-3596-3
https://doi.org/10.1007/s11745-011-3596-3
Autor:
Stephanie Young, Weikang Tao, Bonnie J. Howell, Ed Carlini, Marc Abrams, Edward Keough, Alan B. Sachs, Laura Sepp-Lorenzino, Andrea Matter, Karen R. Leander, Bin Shi
Publikováno v:
Journal of Histochemistry & Cytochemistry. 59:727-740
Chemically stabilized small interfering RNA (siRNA) can be delivered systemically by intravenous injection of lipid nanoparticles (LNPs) in rodents and primates. The biodistribution and kinetics of LNP–siRNA delivery in mice at organ and cellular r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9b8fb9589171de40eeb1680b0c58a8ff
https://doi.org/10.1369/0022155411410885
https://doi.org/10.1369/0022155411410885
Autor:
Kenny K. Wong, Brian K. Hubbard, Alison M. Strack, Beverly Galinski, Mollie Ranalletta, Lei Zhu, Harry R. Davis, Alice C. Stefanni, Natalya Dubinina, Glen Tetzloff, Samnang Tep, Ferdie Soriano, Yiming Xu, Marija Tadin-Strapps, Brandon Ason, Nelly A. Kuklin, Alan B. Sachs, Steven R. Bartz, W. Michael Flanagan
Publikováno v:
Journal of Lipid Research, Vol 52, Iss 4, Pp 679-687 (2011)
Reducing circulating LDL-cholesterol (LDL-c) reduces the risk of cardiovascular disease in people with hypercholesterolemia. Current approaches to reduce circulating LDL-c include statins, which inhibit cholesterol synthesis, and ezetimibe, which blo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::29d16732b43bfa392ff03a089f904ff8
https://doi.org/10.1194/jlr.m013664
https://doi.org/10.1194/jlr.m013664
Autor:
Elmer Payson, Paula J. Hancock, Yi Pei, Natalya Dubinina, Michael Krimm, Ananda Card, Mark T. Cancilla, Jeffrey P. Jones, Jerome H. Hochman, Nelly A. Kuklin, W. Michael Flanagan, Brandon Ason, Julja Burchard, Jie Wei, Alan B. Sachs, Jing Kang, Mark Stroh
Publikováno v:
Molecular Pharmacology. 79:953-963
Deeper knowledge of pharmacokinetic and pharmacodynamic (PK/PD) concepts for RNA therapeutics is important to streamline the drug development process and for rigorous selection of best performing drug candidates. Here we characterized the PK/PD relat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4203c3f450b1d5899c8146ff9ef456a9
https://doi.org/10.1124/mol.110.070409
https://doi.org/10.1124/mol.110.070409
Autor:
Marc Abrams, Jessica Seitzer, Laura Sepp-Lorenzino, Yi Pei, René Bartz, Paul A. Burke, Nathalie Innocent, Yan Xu, Stanley F. Barnett, Craig Cherrin, Colin J. Pomerantz, Paula J. Hancock, Hangchun Zhang, Martin Koser, Alan B. Sachs, Nelly A. Kuklin
Publikováno v:
RNA. 16:2553-2563
Effective small interfering RNA (siRNA)–mediated therapeutics require the siRNA to be delivered into the cellular RNA-induced silencing complex (RISC). Quantitative information of this essential delivery step is currently inferred from the efficacy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::141d5c012134856b27324ebfeee4d04d
https://doi.org/10.1261/rna.2255810
https://doi.org/10.1261/rna.2255810
Autor:
Alan B. Sachs, Walter Strapps, Barry A. Polisky, Gladys T. Muiru, Stacey Orsborn, Victoria Pickering, Julie Rice, Steven R. Bartz
Publikováno v:
Nucleic Acids Research
The use of short interfering RNAs (siRNA) in animals for target validation or as potential therapeutics is hindered by the short physical half-life when delivered as unencapsulated material and in turn the short active half-life of siRNAs in vivo. He
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5dbb9242901e648f0c01e9a4b13ae007
http://europepmc.org/articles/PMC2919711
http://europepmc.org/articles/PMC2919711
Autor:
Alan B. Sachs, Matthew C. Wiener, Ernst S. Henle, Adam J. Simon, Andy Liaw, Andrey Bondarenko, Nathan A. Yates, Fanyu Meng, Ronald C. Hendrickson, Jacquelynn J. Cook, Anita Y. H. Lee, Holly Funk Sleph, Mark S. Shearman, Sethu Sankaranarayanan, Robert E. Settlage, Jeffrey R. Sachs, Marie A. Holahan, Brandon T. Hunt, Cloud P. Paweletz, Qinghua Song
Publikováno v:
Journal of Proteome Research. 9:1392-1401
The rapid identification of protein biomarkers in biofluids is important to drug discovery and development. Here, we describe a general proteomic approach for the discovery and identification of proteins that exhibit a statistically significant diffe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::13d255981c794105e2811c257bba85e3
https://doi.org/10.1021/pr900925d
https://doi.org/10.1021/pr900925d