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pro vyhledávání: '"Alan B. Rose"'
Autor:
Alan B. Rose
Publikováno v:
Frontiers in Genetics, Vol 9 (2019)
A picture is beginning to emerge from a variety of organisms that for a subset of genes, the most important sequences that regulate expression are situated not in the promoter but rather are located within introns in the first kilobase of transcribed
Externí odkaz:
https://doaj.org/article/1e6c0c17696f4d6ea626258f403b8429
Publikováno v:
Frontiers in Plant Science, Vol 2 (2011)
Many introns significantly increase gene expression through a process termed Intron-Mediated Enhancement (IME). Introns exist in the transcribed DNA and the nascent RNA, and could affect expression from either location. To determine which is more rel
Externí odkaz:
https://doaj.org/article/d2ebcf2aa219442c92f683e210e00489
Autor:
Alan B. Rose, Jenna E. Gallegos
Publikováno v:
Scientific Reports, Vol 9, Iss 1, Pp 1-9 (2019)
Scientific Reports
Scientific Reports
Certain introns significantly increase mRNA accumulation by a poorly understood mechanism. These introns have no effect when located upstream, or more than ~1 Kb downstream, of the start of transcription. We tested the ability of a formerly non-stimu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4512a896edcc0e3a82f789e36f715f2b
http://link.springer.com/article/10.1038/s41598-019-50389-5
http://link.springer.com/article/10.1038/s41598-019-50389-5
Autor:
Alan B. Rose, Jenna E. Gallegos
Certain introns strongly increase mRNA accumulation by a poorly understood mechanism known as Intron-Mediated Enhancement (IME). Introns that boost expression by IME have no effect when located upstream of or more than ~1 Kb downstream from the start
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dd7fca0b4449720ec3edaaa023c1e2cd
Autor:
Alan B. Rose, Jenna E. Gallegos
Publikováno v:
Plant Science. 237:8-15
Within two years of their discovery in 1977, introns were found to have a positive effect on gene expression. Numerous examples of stimulatory introns have been described since then in very diverse organisms, including plants. In some cases, the mech
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::42e113f7f52202a256d0ce414089ac63
https://doi.org/10.1016/j.plantsci.2015.04.017
https://doi.org/10.1016/j.plantsci.2015.04.017
Autor:
Alan B. Rose, Jenna E. Gallegos
To more precisely define the positions from which certain intronic regulatory sequences increase mRNA accumulation, the effect of a UBIQUITIN intron on gene expression was tested from six different positions surrounding the transcription start site (
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::570970334399ca54a95ab14c0b72be17
https://europepmc.org/articles/PMC5435436/
https://europepmc.org/articles/PMC5435436/
Publikováno v:
Plant Biotechnology Journal. 11:555-563
Introns are often added to transgenes to increase expression, although the mechanism through which introns stimulate gene expression in plants and other eukaryotes remains mysterious. While introns vary in their effect on expression, it is unknown wh
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::920bfcdba7b338c0ca8881e2a71d62e1
https://doi.org/10.1111/pbi.12043
https://doi.org/10.1111/pbi.12043
Autor:
Alan B. Rose, Jenna E. Gallegos
In diverse eukaryotes, certain introns increase mRNA accumulation through the poorly understood mechanism of intron-mediated enhancement (IME). A distinguishing feature of IME is that these introns have no effect from upstream or more than 1 Kb downs
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5662c68dc427f3cc1b859466454ab4fa
Publikováno v:
Plant molecular biology. 92(3)
Related motifs strongly increase gene expression when added to an intron located in coding sequences. Many introns greatly increase gene expression through a mechanism that remains elusive. An obstacle to understanding intron-mediated enhancement (IM
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::153b5ebf37a86ebddc3b46ae43a06a4d
https://pubmed.ncbi.nlm.nih.gov/27492360
https://pubmed.ncbi.nlm.nih.gov/27492360
Publikováno v:
The Plant Cell. 20:543-551
Introns that elevate mRNA accumulation have been found in a wide range of eukaryotes. However, not all introns affect gene expression, and direct testing is currently the only way to identify stimulatory introns. Our genome-wide analysis in Arabidops
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6ccac814cd3cf5950951e5ac87e5db32
https://doi.org/10.1105/tpc.107.057190
https://doi.org/10.1105/tpc.107.057190