Zobrazeno 1 - 10
of 127
pro vyhledávání: '"Alan B Tuck"'
Autor:
Bart Kolendowski, Haider Hassan, Milica Krstic, Majdina Isovic, Gobi Thillainadesan, Ann F. Chambers, Alan B. Tuck, Joseph Torchia
Publikováno v:
Epigenetics & Chromatin, Vol 11, Iss 1, Pp 1-19 (2018)
Abstract Background The estrogen receptor (ER) is a ligand-dependant transcription factor expressed in many breast cancers and is the target of many endocrine-based cancer therapies. Genome-wide studies have shown that the ER binds to gene-specific e
Externí odkaz:
https://doaj.org/article/0c534c020e9b47d59484461438530b5e
Autor:
Milica Krstic, Alan B. Tuck, Pieter H. Anborgh, Ann F. Chambers, Haider M. Hassan, Bart Kolendowski, Joseph Torchia, Carl O. Postenka, M. Nicole Hague
Publikováno v:
Laboratory Investigation; a Journal of Technical Methods and Pathology
TBX3 is a member of the highly conserved family of T-box transcription factors involved in embryogenesis, organogenesis and tumor progression. While the functional role of TBX3 in tumorigenesis has been widely studied, less is known about the specifi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::07dd4bd86bad43df5ada8645fe8f1b4c
http://europepmc.org/articles/PMC7044113
http://europepmc.org/articles/PMC7044113
Autor:
Milica Krstic, Joseph Torchia, Connor D MacMillan, Haider M. Hassan, Karla C. Williams, Joseph Andrews, Ann F. Chambers, Carl O. Postenka, Matthew J. Cecchini, Alan B. Tuck, Bart Kolendowski, Muriel Brackstone, Hon S. Leong
Publikováno v:
Paediatrics Publications
The Journal of Pathology
The Journal of Pathology
The acquisition of cellular invasiveness by breast epithelial cells and subsequent transition from ductal carcinoma in situ (DCIS) to invasive breast cancer is a critical step in breast cancer progression. Little is known about the molecular dynamics
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::955b99706156949f289d6264e3df9a25
https://doi.org/10.1002/path.5245
https://doi.org/10.1002/path.5245
Autor:
Karlee Searle, Yohan Kim, Karla C. Williams, Ann F. Chambers, Ashley V. Makela, Paula J. Foster, John A. Ronald, Alan B. Tuck, Sepideh Soukhtehzari, Mario A. Cepeda, Katie M. Parkins, Amanda M. Hamilton, Hon S. Leong, Sumreen Javed
Publikováno v:
Oncogene
Invadopodia are cell protrusions that mediate cancer cell extravasation but the microenvironmental cues and signaling factors that induce invadopodia formation during extravasation remain unclear. Using intravital imaging and loss of function experim
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::31ebf1bd98128bba72b3a6e3e69be959
https://doi.org/10.1038/s41388-018-0667-4
https://doi.org/10.1038/s41388-018-0667-4
Autor:
Mai Uyen Nguyen, Ali Abbara, Muriel Brackstone, Paul Bech, Wei-Xing Zong, Andy V. Babwah, Sharon R. Pine, Sophie A Clarke, Stephania Guzman, Frederic E. Wondisford, Waljit S. Dhillo, David A. Hess, Cameron Goertzen, Xiaoyang Su, Magdalena Dragan, Alan B. Tuck, Moshmi Bhattacharya
Publikováno v:
Paediatrics Publications
Cell Death & Disease
Cell Death and Disease, Vol 11, Iss 2, Pp 1-20 (2020)
Cell Death & Disease
Cell Death and Disease, Vol 11, Iss 2, Pp 1-20 (2020)
Triple-negative breast cancer (TNBC) is a highly metastatic and deadly disease. TNBC tumors lack estrogen receptor (ERα), progesterone receptor (PR), and HER2 (ErbB2) and exhibit increased glutamine metabolism, a requirement for tumor growth. The G
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9ea3f5c27cb0db847eb0500d80c8c161
https://doi.org/10.1038/s41419-020-2305-7
https://doi.org/10.1038/s41419-020-2305-7
Autor:
Michael M Mehta, Andy V. Babwah, Moshmi Bhattacharya, Navin Viswakarma, Magdalena Dragan, Frederic E. Wondisford, Ajay Rana, Alan B. Tuck, Michelle M Noonan, David A. Hess, Muriel Brackstone
Publikováno v:
Paediatrics Publications
Oncotarget
Oncotarget
Breast cancer is a leading cause of cancer mortality. In particular, triple negative breast cancer (TNBC) comprise a heterogeneous group of basal-like tumors lacking estrogen receptor (ERα), progesterone receptor (PR) and HER2 (ErbB2). TNBC represen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ef7f305a3539ca9f7f88a4f455405991
https://doi.org/10.18632/oncotarget.25682
https://doi.org/10.18632/oncotarget.25682
Autor:
Wedad Hanna, Prashant A. Jani, Eileen Rakovitch, Michel Bonin, Bruce Youngson, Cindy Fong, Sandip SenGupta, S. Gu, Lawrence Paszat, Rinku Sutradhar, Alan B. Tuck, Nicola Miller, Nafisha Lalani, Martin C. Chang, Leela Elavathil, Sharon Nofech-Mozes, SJ Done
Publikováno v:
Cancer Research. 78:P4-15
Background: Ductal Carcinoma in Situ (DCIS) is a non-invasive breast cancer often treated with breast-conserving surgery (BCS) with or without radiotherapy (RT). It is unclear if the presence of microinvasion (MI) (invasion ≤1mm) is associated with
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a184e8bb2a5095edef929dd363f148a2
https://doi.org/10.1158/1538-7445.sabcs17-p4-15-05
https://doi.org/10.1158/1538-7445.sabcs17-p4-15-05
Autor:
Joseph Andrews, Wendy Kennette, Jenna Pilon, Alexandra Hodgson, Alan B Tuck, Ann F Chambers, David I Rodenhiser
Publikováno v:
PLoS ONE, Vol 5, Iss 1, p e8665 (2010)
BackgroundWe have previously identified genome-wide DNA methylation changes in a cell line model of breast cancer metastasis. These complex epigenetic changes that we observed, along with concurrent karyotype analyses, have led us to hypothesize that
Externí odkaz:
https://doaj.org/article/083ed21a7a92410faf37d5733e161a66
Autor:
Ann F. Chambers, Muriel Brackstone, Francisco Perera, Theodore A. Vandenberg, Donald H. Taves, David D'Souza, David A. Palma, Leslie Scott, Kylea Potvin, Alan B. Tuck, Anat Kornecki, Giulio Muscedere
Publikováno v:
International Journal of Radiation Oncology*Biology*Physics. 99:769-776
Purpose To evaluate whether concurrent neoadjuvant radiation added to standard chemotherapy could increase the pathologic complete response (pCR) to treatment for locally advanced breast cancer (LABC). Methods and Materials This prospective phase 2 t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4d80ceccf1ed0a677471c2e47a3ac752
https://doi.org/10.1016/j.ijrobp.2017.06.005
https://doi.org/10.1016/j.ijrobp.2017.06.005
Autor:
Sandip SenGupta, Alan B. Tuck, Eileen Rakovitch, Sharon Nofech-Mozes, Martin C. Chang, Cindy Fong, Bruce Youngson, Prashant A. Jani, S. Gu, Lawrence Paszat, Nicola Miller, Michel Bonin, Wedad Hanna, Leela Elavathil, SJ Done
Publikováno v:
Cancer Research. 77:P3-17
Background: Despite evidence that radiotherapy (RT) after breast-conserving surgery (BCS) for ductal carcinoma in situ (DCIS) halves the risk of recurrence, the benefit of RT in the management of DCIS continues to be a matter of controversy. One argu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::dd03a2afaf63f1ed6be67478cacf0157
https://doi.org/10.1158/1538-7445.sabcs16-p3-17-01
https://doi.org/10.1158/1538-7445.sabcs16-p3-17-01