Zobrazeno 1 - 10
of 56
pro vyhledávání: '"Alan B Clark"'
Autor:
Katherine H. O. Deane, Richard Gray, Paula Balls, Clare Darrah, Louise Swift, Alan B. Clark, Garry R. Barton, Sophie Morris, Sue Butters, Angela Bullough, Helen Flaherty, Barbara Talbot, Mark Sanders, Simon T. Donell
Publikováno v:
BMC Health Services Research, Vol 18, Iss 1, Pp 1-16 (2018)
Abstract Background Self-administration of medicines by patients whilst in hospital is being increasingly promoted despite little evidence to show the risks and benefits. Pain control after total knee replacement (TKR) is known to be poor. The aim of
Externí odkaz:
https://doaj.org/article/b484611afa9743148cc5d2fe3bef4f77
Supplementary Table & Figure from An Msh2 Point Mutation Uncouples DNA Mismatch Repair and Apoptosis
Autor:
Winfried Edelmann, Thomas A. Kunkel, Martin Lipkin, Raju Kucherlapati, Asad Umar, Naoto Kurihara, Tchaiko Parris, Uwe Werling, Bo Jin, Elena Avdievich, Kan Yang, Alan B. Clark, Stefan J. Scherer, Yuxun Wang, Diana P. Lin
Supplementary Table & Figure from An Msh2 Point Mutation Uncouples DNA Mismatch Repair and Apoptosis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::11a14c45631c1a14770141389b380935
https://doi.org/10.1158/0008-5472.22363571
https://doi.org/10.1158/0008-5472.22363571
Autor:
Winfried Edelmann, Thomas A. Kunkel, Martin Lipkin, Raju Kucherlapati, Asad Umar, Naoto Kurihara, Tchaiko Parris, Uwe Werling, Bo Jin, Elena Avdievich, Kan Yang, Alan B. Clark, Stefan J. Scherer, Yuxun Wang, Diana P. Lin
Mutations in the human DNA mismatch repair gene MSH2 are associated with hereditary nonpolyposis colorectal cancer as well as a significant proportion of sporadic colorectal cancer. The inactivation of MSH2 results in the accumulation of somatic muta
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::649463415b136ec0825f4430b1d667ac
https://doi.org/10.1158/0008-5472.c.6493781
https://doi.org/10.1158/0008-5472.c.6493781
Autor:
Scott A Lujan, Jessica S Williams, Zachary F Pursell, Amy A Abdulovic-Cui, Alan B Clark, Stephanie A Nick McElhinny, Thomas A Kunkel
Publikováno v:
PLoS Genetics, Vol 8, Iss 10, p e1003016 (2012)
The two DNA strands of the nuclear genome are replicated asymmetrically using three DNA polymerases, α, δ, and ε. Current evidence suggests that DNA polymerase ε (Pol ε) is the primary leading strand replicase, whereas Pols α and δ primarily p
Externí odkaz:
https://doaj.org/article/4ffe57f571794dcaa7c510f291e09901
Autor:
Paula Balls, Helen Flaherty, Alan B. Clark, Katherine H O Deane, Barbara Talbot, Louise Swift, Simon T. Donell, Angela Bullough, Mark Sanders, Sophie Morris, Garry Barton, Sue Butters, Richard Gray, C. Darrah
Publikováno v:
BMC Health Services Research, Vol 18, Iss 1, Pp 1-16 (2018)
BMC Health Services Research
BMC Health Services Research
Background Self-administration of medicines by patients whilst in hospital is being increasingly promoted despite little evidence to show the risks and benefits. Pain control after total knee replacement (TKR) is known to be poor. The aim of the stud
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0c2a5fce9c602b513a7c2b1ca18eaf79
http://link.springer.com/article/10.1186/s12913-018-3146-2
http://link.springer.com/article/10.1186/s12913-018-3146-2
Autor:
Zhi-Xiong Zhou, Scott A. Lujan, Adam B. Burkholder, Jessica S. Williams, Alan B. Clark, Thomas A. Kunkel, David C. Fargo
Publikováno v:
DNA Repair (Amst)
Ribonucleotides are the most common non-canonical nucleotides incorporated into DNA during replication, and their processing leads to mutations and genome instability. Yeast mutation reporter systems demonstrate that 2-5 base pair deletions (Δ2-5bp)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bfb414c766457446df26649f7e5f5abe
https://europepmc.org/articles/PMC6901746/
https://europepmc.org/articles/PMC6901746/
Publikováno v:
Nucleic Acids Research
Mutation rates are used to calibrate molecular clocks and to link genetic variants with human disease. However, mutation rates are not uniform across each eukaryotic genome. Rates for insertion/deletion (indel) mutations have been found to vary widel
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1f4a587be51410895be8e1d83c762e48
https://doi.org/10.1093/nar/gkv271
https://doi.org/10.1093/nar/gkv271
Autor:
Scott A. Lujan, Anders R. Clausen, Lisette Marjavaara, Thomas A. Kunkel, Andrei Chabes, Alan B. Clark, Peter M. J. Burgers, Jessica S. Williams
Publikováno v:
Nature Structural & Molecular Biology. 22:291-297
Ribonucleotides incorporated during nuclear DNA replication are removed by RNase H2-dependent ribonucleotide excision repair (RER). When RER is defective, topoisomerase 1 (Top1) incises the DNA at unrepaired ribonucleotides, initiating their removal
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::62a71ce217addb8d3082592e5987b45a
https://doi.org/10.1038/nsmb.2989
https://doi.org/10.1038/nsmb.2989
Autor:
Piotr A. Mieczkowski, Adam B. Burkholder, Dmitry A. Gordenin, Alan B. Clark, Anders R. Clausen, David M. MacAlpine, Thomas A. Kunkel, Scott A. Lujan, David C. Fargo, Ewa P. Malc, Heather K. MacAlpine
Publikováno v:
Genome Research. 24:1751-1764
DNA synthesis errors are a dual-edged sword. At a population level, accurate DNA replication maintains species identity, yet a small fraction of replication errors creates mutations that improve fitness and fuel evolution. At an individual level, DNA
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f35ec06e66dd1c0f7a34081cf8fc62d6
https://doi.org/10.1101/gr.178335.114
https://doi.org/10.1101/gr.178335.114
Autor:
Andrei Chabes, Stephanie A. Nick McElhinny, Brian E. Watts, Danielle L. Watt, Thomas A. Kunkel, Alan B. Clark, Dinesh Kumar, Erik Johansson, Else-Britt Lundström
Publikováno v:
Nature chemical biology
Maintaining the chemical identity of DNA depends on ribonucleotide exclusion by DNA polymerases. However, ribonucleotide exclusion during DNA synthesis in vitro is imperfect. To determine whether ribonucleotides are incorporated during DNA replicatio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cead0f11b712ef1aae76938850bc085b
http://europepmc.org/articles/PMC2942972
http://europepmc.org/articles/PMC2942972