Prognostic relevance of cytochrome C oxidase in primary glioblastoma multiforme.

Autor: Corinne E Griguer, Alan B Cantor, Hassan M Fathallah-Shaykh, G Yancey Gillespie, Amber S Gordon, James M Markert, Ivan Radovanovic, Virginie Clement-Schatlo, Chevis N Shannon, Claudia R Oliva

Publikováno v: PLoS ONE, Vol 8, Iss 4, p e61035 (2013)

Patients with primary glioblastoma multiforme (GBM) have one of the lowest overall survival rates among cancer patients, and reliable biomarkers are necessary to predict patient outcome. Cytochrome c oxidase (CcO) promotes the switch from glycolytic

Externí odkaz: https://doaj.org/article/110fffff13da485a8b7c0d2c1a50d196

Germline GATA1s-generating mutations predispose to leukemia with acquired trisomy 21 and Down syndrome-like phenotype

Autor: Vijay G. Sankaran, Deepa Bhojwani, C. Michel Zwaan, Nik F Nik-Abdul-Rashid, Josefine Palle, Jeffrey M Verboon, Stephanie DiTroia, Klas Raaschou-Jensen, Charlotte Guldborg Nyvold, Alan B. Cantor, Katherine R. Chao, Ronald M Kline, Henrik Hasle, Eigil Kjeldsen

Publikováno v: Hasle, H, Kline, R M, Kjeldsen, E, Nik-Abdul-Rashid, N F, Bhojwani, D, Verboon, J M, DiTroia, S P, Chao, K R, Raaschou-Jensen, K, Palle, J, Zwaan, C M, Nyvold, C G, Sankaran, V G & Cantor, A B 2022, ' Germline GATA1s generating mutations predispose to leukemia with acquired trisomy 21 and Down syndrome-like phenotype ', Blood, vol. 139, no. 21, pp. 3159–3165 . https://doi.org/10.1182/blood.2021011463
Blood
Blood, 139(21), 3159-3165. American Society of Hematology

Individuals with Down syndrome are at increased risk of myeloid leukemia in early childhood, which is associated with acquisition of GATA1 mutations that generate a short GATA1 isoform called GATA1s. Germline GATA1s-generating mutations result in con

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a1225de3f1a4ae2eeb74f3fa46f7b899
http://www.scopus.com/inward/record.url?scp=85131076117&partnerID=8YFLogxK

Pregnancy and Birth Outcomes among Women with Idiopathic Thrombocytopenic Purpura

Autor: Diego F. Wyszynski, Wendy J. Carman, Alan B. Cantor, John M. Graham, Liza H. Kunz, Anne M. Slavotinek, Russell S. Kirby, John Seeger

Publikováno v: Journal of Pregnancy, Vol 2016 (2016)

Objective. To examine pregnancy and birth outcomes among women with idiopathic thrombocytopenic purpura (ITP) or chronic ITP (cITP) diagnosed before or during pregnancy. Methods. A linkage of mothers and babies within a large US health insurance data

Externí odkaz: https://doaj.org/article/b23b6696a8c24f56838d0a4ba16b86c1

Somatic mutational landscape of hereditary hematopoietic malignancies associated with germline variants in RUNX1, GATA2 and DDX41

Autor: Anna L. Brown, Claire Homan, Michael W. Drazer, Kai Yu, David Lawrence, Jinghua Feng, Luis Arriola-Martinez, Matthew Pozsgai, Kelsey McNeely, Thuong Ha, Parvathy Venugopal, Peer Arts, Sarah King-Smith, Jesse JC Cheah, Mark Armstrong, Csaba Bödör, Paul Wang, Alan B. Cantor, Mario Cazzola, Erin Degelman, Courtney D. DiNardo, Nicolas Duployez, Remi Favier, Stefan Fröhling, Ana Rio-Machin, Jeffery M. Klco, Alwin Krämer, Mineo Kurokawa, Joanne Lee, Luca Malcovati, Neil V Morgan, Georges Natsoulis, Carolyn Owen, Keyur P. Patel, Claude Preudhomme, Hana Raslova, Hugh Young Rienhoff, Tim Ripperger, Rachael Schulte, Kiran Tawana, Elvira Deolinda Rodrigues Pereira Velloso, Benedict Yan, Raman Sood, Amy Hsu, Steven M. Holland, Kerry Phillips, Nicola Poplawski, Milena Babic, Erika M Kwon Kim, Andrew H. Wei, Cecily Forsyth, Helen Mar Fan, Ian D Lewis, Julian Cooney, Rachel Susman, Lucy C Fox, Piers Blombery, Deepak Singhal, Devendra Hiwase, Andreas W Schreiber, Christopher N Hahn, Hamish S Scott, Paul P. Liu, Lucy A. Godley

Germline variants in RUNX1, GATA2 and DDX41 may confer a predisposition to hereditary haematopoietic malignancies (HHMs) such as MDS and AML yet have distinct age ranges of malignancy diagnosis and a highly variable overall risk for leukemogenesis. T

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3a20f1d2adfa0dcd6854f8f7a941739a
https://hdl.handle.net/11541.2/33177

B-cell acute lymphoblastic leukemia in patients with germline RUNX1 mutations

Autor: Andrew E. Place, Serine Avagyan, Ulrike Gerdemann, Alan B. Cantor, Matthew A. Kutny, Anna L. Brown, Kathryn A. Six

Publikováno v: Blood Adv

Germline RUNX1 mutations underlie a syndrome, RUNX1-familial platelet disorder (RUNX1-FPD), characterized by bleeding symptoms that result from quantitative and/or qualitative defect in platelets and a significantly increased risk for developing hema

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::74d07758fde677689c04aff873fb805b
https://europepmc.org/articles/PMC8405188/